Opto-Electrical Cochlear Implants
光电人工耳蜗
基本信息
- 批准号:10618825
- 负责人:
- 金额:$ 40.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-02-15 至 2026-01-31
- 项目状态:未结题
- 来源:
- 关键词:Acoustic NerveAcoustic StimulationAcousticsAction PotentialsAcuteAmericanAnimal ModelAuditoryBionicsClinicClinicalCochleaCochlear ImplantsCollaborationsCommunicationCraniotomyDataDevelopmentDiameterElectric StimulationElectric WiringElectrodesEncapsulatedEnvironmentEquipmentExcisionFelis catusFiber OpticsGoalsGood Manufacturing ProcessHearingHumanHybridsImplantImplanted ElectrodesIndustrializationInfrared RaysInstitutionIntraoperative MonitoringLanguageLengthLightManufacturerMeasurementMeasuresMedical DeviceMethodsModalityMonitorMusicNeuronsOperating RoomsOperative Surgical ProceduresOpticsPatientsPerceptionPerformancePhotonsPhysiologic pulsePolishesPreparationPsychophysicsPulse RatesRadiationResearchRiskRisk AssessmentSalineScala TympaniScientistSiliconesSiteSkull Base NeoplasmsSocietiesSourceSpecific qualifier valueStimulusSurgeonSystemTechnologyTemperatureTestingTimeTissuesTranslatingUnited States Food and Drug AdministrationWorkWritingaqueousclinical centerdeafdesignexperienceexperimental studyfabricationfirst-in-humanhuman studyimplantable deviceimprovedin vivoindustry partnermanufactureminiaturizeneural prosthesisneural stimulationnext generationnoveloptical fiberphysical propertypre-clinical researchprototyperecruitresponseround windowsoundspeech in noisespiral ganglionsuccesstooltumorwaveguide
项目摘要
Project Summary / Abstract
Our goal is to develop an optical cochlear implant (oCI) that uses photons to stimulate surviving auditory
neurons in severely-to-profoundly deaf. The benefit of optical stimulation is its spatial selectivity with the
potential to create significantly more independent channels to encode acoustic information and to enhance the
CI users’ performance in challenging listening environments and to improve music appreciation. In previous
experiments we have defined the parameter space for infrared neural stimulation (INS) in diverse animal
models, including the cat. To translate the method into a clinical tool, an opto-electrical cochlear implant, we
have to convert the parameter space defined for the cats to the larger cochlea of the humans. In preparation of
the study we have communicated with the Food and Drug Administration (FDA) and have submitted a Q-
submission for a study risk assessment for the first set of the proposed tests. The purpose of this study is to
show that optical and combined opto-electrical stimulation is possible in humans using optical fibers, optical
fiber bundles, and a hybrid opto-electrical cochlear implant. Furthermore, the tests will also validate that INS is
possible at radiation wavelengths, which are used commercially in communication and for which the
technology of optical sources and waveguides is well miniaturized and matured. Most importantly, we will use a
forward masking method to validate the view that optical stimulation is spatially more selective than electrical
stimulation by comparing the ability of a masking stimulus to reduce the response amplitude of a probe
stimulus. Test subjects will be patients with large tumors of the skull base, who require a translabyrinthine
craniotomy for tumor removal. For this surgical approach the cochlea and vestibular system will be damaged
and the patients will be deaf after surgery. This surgery provides an unique opportunity to test optical
stimulation in the human cochlea before it is removed during the tumor resection. Important data can be
gathered, which will drive the development of an implantable opto-electrical cochlear implant system by our
industrial collaborators. The measurements will take no longer than 30 minutes per patient, after which all the
equipment will be removed from the surgical filed and the tumor resection surgery continues.
项目总结/摘要
我们的目标是开发一种光学人工耳蜗(oCI),使用光子刺激幸存的听觉
神经元的数量。光刺激的益处是其空间选择性,
潜在的创造明显更多的独立通道来编码声学信息,并提高
CI用户在具有挑战性的聆听环境中的表现,并提高音乐欣赏能力。前几
通过实验,我们确定了不同动物的红外神经刺激(INS)的参数空间
模型,包括猫。为了将该方法转化为临床工具,光电耳蜗植入物,我们
必须将为猫定义的参数空间转换为人类的较大耳蜗。在制备
我们已经与美国食品药品监督管理局(FDA)沟通了这项研究,并提交了一份Q-
提交第一组拟定试验的研究风险评估。本研究的目的是
显示了使用光纤、光学传感器、光学
纤维束和混合光电耳蜗植入物。此外,测试还将验证INS是
在通信中商业使用的辐射波长下,
光源和波导的技术已经很好地小型化和成熟。最重要的是,我们将使用
前向掩蔽方法,以验证光学刺激比电刺激在空间上更具选择性的观点
通过比较掩蔽刺激降低探针响应幅度的能力来确定刺激
刺激。测试对象将是患有颅底大肿瘤的患者,他们需要一个transmartine。
开颅切除肿瘤这种手术方法会损伤耳蜗和前庭系统
手术后病人会失聪这个手术提供了一个独特的机会来测试光学
在肿瘤切除术期间,在人类耳蜗被移除之前,对人类耳蜗进行刺激。重要数据可以
收集,这将推动我们的植入式光电人工耳蜗系统的发展。
工业合作者。每个患者的测量时间不超过30分钟,之后所有的
设备将从手术区域移除,肿瘤切除手术继续进行。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CLAUS-PETER RICHTER其他文献
CLAUS-PETER RICHTER的其他文献
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{{ truncateString('CLAUS-PETER RICHTER', 18)}}的其他基金
Understanding the Benefits of Optical Nerve Stimulators for Neural Interfaces
了解视神经刺激器对神经接口的好处
- 批准号:
9933646 - 财政年份:2019
- 资助金额:
$ 40.75万 - 项目类别:
Understanding the Benefits of Infrared Nerve Stimulators for Neural Interfaces
了解红外神经刺激器对神经接口的好处
- 批准号:
8434109 - 财政年份:2012
- 资助金额:
$ 40.75万 - 项目类别:
Understanding the Benefits of Infrared Nerve Stimulators for Neural Interfaces
了解红外神经刺激器对神经接口的好处
- 批准号:
8297930 - 财政年份:2012
- 资助金额:
$ 40.75万 - 项目类别:
Understanding the Benefits of Infrared Nerve Stimulators for Neural Interfaces
了解红外神经刺激器对神经接口的好处
- 批准号:
8640907 - 财政年份:2012
- 资助金额:
$ 40.75万 - 项目类别:
Understanding the Benefits of Infrared Nerve Stimulators for Neural Interfaces
了解红外神经刺激器对神经接口的好处
- 批准号:
9012072 - 财政年份:2012
- 资助金额:
$ 40.75万 - 项目类别:
Development of a Novel Laser Instrument for Advanced Medical Applications
开发用于先进医疗应用的新型激光仪器
- 批准号:
8299462 - 财政年份:2011
- 资助金额:
$ 40.75万 - 项目类别:
Development of a Novel Laser Instrument for Advanced Medical Applications
开发用于先进医疗应用的新型激光仪器
- 批准号:
8531011 - 财政年份:2011
- 资助金额:
$ 40.75万 - 项目类别:
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