Investigating neural mechanisms of hypersensitivity in chronic pain

研究慢性疼痛超敏反应的神经机制

• 批准号: 10619192
• 负责人: Tony Edward Larkin
• 金额: $ 7.78万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-31 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10619192
• 关键词: Anterior; Area; Brain; Brain region; Central Nervous System; Central Nervous System Diseases; Chronic; Communication; Complex; Computing Methodologies; Data; Diffuse; Fibromyalgia; Functional Magnetic Resonance Imaging; Functional disorder; Future; Goals; Headache; Hyperalgesia; Hypersensitivity; Impairment; Individual; Insula of Reil; Interstitial Cystitis; Intervention; Intestines; Knowledge; Learning; Light; Low Back Pain; Measures; Mission; Multimodal Imaging; Neurosciences Research; Nociception; Odors; Pain; Participant; Pathway Analysis; Pathway interactions; Patients; Phase; Photic Stimulation; Play; Property; Public Health; Research; Rest; Role; Sensory; Stimulus; Structure; Temporomandibular Joint Disorders; Testing; Thalamic structure; Thinking; Touch sensation; Training; United States National Institutes of Health; Visual; Work; allodynia; central pain; chronic pain; chronic pain patient; clinical pain; experience; flexibility; functional group; gray matter; healthy volunteer; insight; multisensory; network architecture; neural; neurochemistry; neuromechanism; novel; pain perception; pain processing; response; sensory integration; sensory stimulus; somatosensory; sound; translational neuroscience; visual processing; visual stimulus

PROJECT SUMMARY/ABSTRACT Pain is a complex experience often associated with noxious stimulation. However, for individuals with Chronic Overlapping Pain Conditions (COPCs), the central nervous system can augment or cause pain in the absence of noxious input. Many of these patients have diffuse hyperalgesia (elevated pain responses to noxious stimuli) and allodynia (perception of pain for non-noxious stimuli). Additionally, chronic pain patients are hypersensitive to a variety of sensory stimuli (such as light, odor and sound), suggesting a global impairment in sensory processing. Pain processing in the CNS normally occurs via ascending and descending nociceptive pathways which integrate in several brain areas, including the thalamus, and the cingulate, somatosensory, prefrontal and insular cortices. Importantly, none of the brain regions mentioned above are uniquely associated with the perception of pain, therefore pain most likely involves coordinated activity within a network of brain regions that play a role in pain perception. Studying the brain as a complex network of interconnected regions might provide unique insights to the underlying pathophysiology of chronic centralized pain conditions Our overall objective is to identify neural mechanisms that contribute to sensory hypersensitivity in chronic pain patients. The short-term training goal for the F99 phase is to learn and use quantitative sensory testing and advanced computational methods to measure functional connectivity and network properties of fMRI data. Network analyses will provide novel insights into the interaction of functional brain networks during sensory processing that contribute to visual hypersensitivity. My dissertation work (Research Aims 1 & 2) along with the training plan will provide evidence for the functional relationship between pain and visual processing areas. This offers a foundational premise for the long-term goal, to be completed during the K00 phase, which is to utilize multimodal imaging to investigate casual interactions between brain areas involved in pain and sensory processing that contribute to hypersensitivity in chronic pain.

项目总结/摘要 疼痛是一种复杂的体验，通常与伤害性刺激有关。然而，对于那些 慢性重叠疼痛状况（COPC），中枢神经系统可以增加或引起疼痛， 没有有害的输入。这些患者中的许多人具有弥漫性痛觉过敏（对疼痛的反应升高）。 伤害性刺激）和异常性疼痛（对非伤害性刺激的疼痛感知）。此外，慢性疼痛患者 对各种感官刺激（如光，气味和声音）过敏，这表明全球 感觉处理的损伤。中枢神经系统中的疼痛处理通常通过上行和下行 整合在几个脑区的伤害感受通路，包括丘脑和扣带回， 躯体感觉、前额叶和岛叶皮层。重要的是，上面提到的大脑区域都不是 与疼痛的感知唯一相关，因此疼痛最有可能涉及协调的活动， 在疼痛感知中发挥作用的大脑区域网络。研究大脑作为一个复杂的网络， 相互连接的区域可能为慢性中枢神经系统疾病的潜在病理生理学提供独特的见解。 疼痛病症 我们的总体目标是确定神经机制，有助于感觉超敏反应， 慢性疼痛患者F99阶段的短期培训目标是学习和使用定量感觉 测试和先进的计算方法来测量功能连接和网络特性， fMRI数据。网络分析将提供新的见解功能性大脑网络的相互作用， 导致视觉超敏的感觉处理。我的论文工作（研究目标1和2）沿着 与训练计划将提供证据疼痛和视觉处理之间的功能关系 地区这为在K 00阶段完成的长期目标提供了一个基本前提， 是利用多模态成像来研究与疼痛有关的大脑区域之间的偶然相互作用， 感觉处理，有助于慢性疼痛的超敏反应。