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Quantitative Analysis of Cancer-associated EVs

Quantitative Analysis of Cancer-associated EVs
癌症相关 EV 的定量分析
批准号：
10604126
负责人：
JOHN P NOLAN
金额：
$100.83万
依托单位：
CELLARCUS BIOSCIENCES INC
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
项目状态：
未结题
起止时间：
2023-06-09 至 2025-05-31
来源：
https://reporter.nih.gov/project-details/10604126
关键词：
AntibodiesAntibody AffinityAntibody SpecificityAutomationBiogenesisBiological AssayBiological MarkersBiological ProcessBiological SciencesBiotechnologyBloodBrainCancerousCell LineCellsCerebrospinal FluidClientCollaborationsColorComplexControlled EnvironmentCryoelectron MicroscopyDataDevelopmentDiagnosisDistantEngineeringFeedbackFlow CytometryFluorescent Antibody TechniqueHeterogeneityImmunoassayLaboratoriesMalignant NeoplasmsMeasurementMeasuresMedical centerMembrane ProteinsMethodsMonitorMonoclonal AntibodiesNeoplasm MetastasisOpticsOrganPathologyPerformancePhasePlasmaPreparationProductionReagentRecurrenceReportingReproducibilityResearchResearch PersonnelResolutionRoleSamplingServicesSiteStandardizationSurfaceTechnologyTest ResultTestingTimeTissuesTumor MarkersUrineValidationVesicleWorkbiomarker panelcancer typedesigndetection limitdiagnostic biomarkerextracellular vesiclesimprovedinterestliquid biopsyneoplastic cellpotential biomarkerresponsetherapeutic biomarkertooltumor progressionvesicular release

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Abstract All cells in the body, including tumor cells, release small vesicles that can be found in blood, cerebrospinal fluid, and even urine. Because each vesicle was released by a specific cell, their analysis can tell us about the cells from which they came, including whether that cell was infected, cancerous, or malfunctioning in some way. We will develop assays and kits to enable cancer researchers to analyze these vesicles to improve the ability to understand, detect and treat cancer.
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