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Assays and kits for MSC-derived extracellular vesicles

Assays and kits for MSC-derived extracellular vesicles
MSC 衍生的细胞外囊泡的检测方法和试剂盒
批准号：
10227192
负责人：
JOHN P NOLAN
金额：
$89.09万
依托单位：
CELLARCUS BIOSCIENCES INC
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
项目状态：
已结题
起止时间：
2020-08-01 至 2023-07-31
来源：
https://reporter.nih.gov/project-details/10227192
关键词：
AddressAdipose tissueAffectAllelesAntibodiesAntibody AffinityAntibody SpecificityAutomationBiological AssayBiological SciencesBiotechnologyBone MarrowCell Culture TechniquesCell TherapyCellsClientClinicalClinical TrialsColorControlled EnvironmentDataDevelopmentDiseaseDistantDoseEngineeringFeedbackFlow CytometryFluorescent Antibody TechniqueHeterogeneityImmunoassayInternationalLaboratoriesMeasurementMeasuresMembrane ProteinsMonitorMonoclonal AntibodiesOpticsOrganPerformancePharmacologic SubstancePhasePreparationProductionPropertyProtocols documentationReagentRegenerative MedicineReportingReproducibilityResearchResearch PersonnelResolutionRoleSafetySamplingServicesSocietiesStandardizationSurfaceTechnologyTestingTherapeuticTherapeutic AgentsTimeTissuesTrainingUmbilical cord structureVesicleWorkanalytical methodbiomarker paneldesigndetection limitdosageextracellular vesiclesin vitro activityin vivointerestliquid biopsymesenchymal stromal cellnovel therapeuticspotential biomarkerreagent standardregenerativeregenerative cellregenerative therapytoolvesicular release

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英文摘要
Abstract All cells release small extracellular vesicles (EVs) that can carry cargo to other cells to affect their function. Mesenchymal stromal cells (MSCs) release EVs that have regenerative activities in vitro and in vivo and which represent potentially valuable new therapeutics. The realization of this potential is hindered by a lack of analytical methods to characterize MSC EVs, determine their mechanisms of action, and establish potency and dosage criteria. We will produce high resolution analysis tools for MSC EVs that will address these limitations and enable their development as new therapeutic entities.
期刊论文(1)
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会议论文
Rigor and reproducibility: status and challenges for single vesicle analysis.
DOI： 10.20517/evcna.2022.28
发表时间： 2022
期刊： Extracellular vesicles and circulating nucleic acids
影响因子： --
作者： [Nolan, John P., Chiu, Daniel T., Welsh, Joshua A.]
通讯作者： Welsh, Joshua A.
Quantitative Analysis of Cancer-associated EVs
  • 批准号：
    10604126
  • 项目类别：
  • 资助金额：
    $100.83万
  • 财政年份：
    2023
  • 负责人：
    JOHN P NOLAN
  • 依托单位：
    CELLARCUS BIOSCIENCES INC
Assays and kits for MSC-derived extracellular vesicles
  • 批准号：
    10082060
  • 项目类别：
  • 资助金额：
    $75.54万
  • 财政年份：
    2020
  • 负责人：
    JOHN P NOLAN
  • 依托单位：
    CELLARCUS BIOSCIENCES INC
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  • 批准号：
    9915908
  • 项目类别：
  • 资助金额：
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  • 财政年份：
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  • 负责人：
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  • 依托单位：
    CELLARCUS BIOSCIENCES INC
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