2023 Translation Machinery in Health and Disease GRC/GRS

项目摘要 要求为健康和疾病-蛋白质合成和细胞方面的翻译机器提供部分支持 Synergy Gordon研究研讨会和Gordon研究会议将于周四在德克萨斯州加尔维斯顿举行 2023年2月19日至24日。据我们所知，这是第一次也是唯一一次以疾病为重点的跨学科会议。 关于信使核糖核酸的翻译。与其他主要关注翻译机制结构的会议不同 及其在蛋白质合成中的作用，这篇GRC的重点是翻译在人类疾病中的作用以及它在蛋白质合成中的作用 病理后果的变化。这一独特的会议为科学家提供了一个讨论的论坛 他们的发现有一个最终的长期目标，那就是建立合作，以了解和发现 疾病的治疗。戈登研究会议的具体目标是召集50名演讲者和 另有125-150名参与者，他们是神经疾病、压力和衰老、癌症、 传染病、核糖病、罕见病、线粒体病、代谢性疾病讨论 基础科学和治疗干预。随之而来的戈登研究研讨会将提供一个论坛 为处于职业生涯早期阶段的科学家介绍他们在翻译、疾病和网络方面的研究 活动。被邀请的演讲者、其他与会者和早期科学家将有许多机会交谈 其他翻译研究领域的研究人员，在不同学科之间交流思想和概念， 并发展新的合作关系。苏珊·阿克曼博士，神经科学和翻译方面的专家 人类生物学翻译专家乔纳森·魏斯曼博士将作主旨演讲 戈登研究会议上的演讲，以及核糖体组装和分析专家Katrin Karbstein博士 Function将在戈登研究研讨会上发表主旨演讲。除了特邀演讲者和演讲者 从摘要中挑选出来的四个海报会议将使所有与会者能够为会议做出贡献。那里 将有许多机会让年轻的调查人员、女性和少数族裔与 翻译字段。会议还包括由GRC赞助的“动力小时”，它将提供一个平台， 讨论女性和其他代表性不足的少数群体在科学界面临的挑战。作为第一个也是唯一一个 翻译与疾病会议，这次会议将对与会者的理解产生重大影响 几个NIH机构感兴趣的几种主要疾病机制。本次会议提供了一个 研究人员研究翻译的关键“翻译”场所。

Project Abstract Partial support is requested for the Translation Machinery in Health and Disease-Protein Synthesis and Cellular Synergy Gordon Research Seminar and Gordon Research Conference to be held in Galveston, Texas on February 19-24, 2023. It is the first and to our knowledge, the only, disease-focused, interdisciplinary meeting on mRNA translation. Unlike other conferences that mainly focus on the structure of the translational machinery and its function in protein synthesis, the focus of this GRC is on the role of translation in human disease and its alternations on pathological consequences. This unique conference provides a forum for scientists to discuss their findings with an ultimate long-term goal of building collaborations toward understanding and finding treatments for disease. The specific aims of the Gordon Research Conference are to convene 50 speakers and an additional 125-150 participants who are experts in the fields of neurological disease, stress and aging, cancer, infectious diseases, ribosomepathies, rare diseases, mitochondrial diseases and metabolic diseases to discuss basic science and therapeutic interventions. The accompanying Gordon Research Seminar will provide a forum for scientists in early stages of their career to present their research on translation and disease and networking activity. The invited speakers, other attendees, and early stage scientists will have many opportunities to talk to researchers in other areas of translation research, exchange ideas and concepts among different disciplines, and develop new collaborations. Dr. Susan Ackerman, an expert in translation aspect of neuroscience and neurodegeneration, and Dr. Jonathan Weissman, an expert in translation in human biology will give keynote lectures at the Gordon Research Conference, and Dr. Katrin Karbstein, an expert on ribosome assembly and function will give the keynote at the Gordon Research Seminar. In addition to invited speakers and speakers chosen from the abstracts, four poster sessions will enable all participants to contribute to the meeting. There will be many opportunities for young investigators, women, and minorities to interact with senior leaders in the translation field. The conference also includes a GRC-sponsored “power hour” which will provide a platform to discuss challenges that women and other underrepresented minorities face in science. As the first and only conference on translation and disease, this conference will significantly impact the participant's understanding of several major disease mechanisms that are of interest to several NIH institutions. This meeting provides a critical “translational” venue for investigators studying translation.