2023 Translation Machinery in Health and Disease GRC/GRS

项目摘要 请求对健康和疾病蛋白质合成和细胞中的翻译机器提供部分支持 协同戈登研究研讨会和戈登研究会议将于 德克萨斯州加尔维斯顿举行 2023 年 2 月 19 日至 24 日。据我们所知，这是第一次也是唯一一次以疾病为重点的跨学科会议 关于 mRNA 翻译。与其他主要关注转化机器结构的会议不同 及其在蛋白质合成中的功能，本次 GRC 的重点是翻译在人类疾病及其中的作用 病理后果的交替。这次独特的会议为科学家提供了一个讨论的论坛 他们的研究结果的最终长期目标是建立合作以理解和发现 疾病的治疗。戈登研究会议的具体目标是召集 50 名发言人， 另外 125-150 名参与者是神经系统疾病、压力和衰老、癌症、 传染病、核糖体病、罕见病、线粒体疾病和代谢性疾病讨论 基础科学和治疗干预。伴随的戈登研究研讨会将提供一个论坛 为处于职业生涯早期阶段的科学家展示他们在翻译、疾病和网络方面的研究 活动。受邀演讲者、其他与会者和早期科学家将有很多机会与他们交谈 其他翻译研究领域的研究人员，在不同学科之间交流思想和概念， 并发展新的合作。 Susan Ackerman 博士，神经科学翻译方面的专家 神经退行性疾病，人类生物学翻译专家 Jonathan Weissman 博士将发表主题演讲 戈登研究会议上的演讲，以及核糖体组装和合成方面的专家 Katrin Karbstein 博士 函数将在戈登研究研讨会上发表主题演讲。除了特邀演讲嘉宾和演讲嘉宾 从摘要中选出的四场海报会议将使所有与会者能够为会议做出贡献。那里 年轻研究人员、女性和少数族裔将有很多机会与高级领导人互动 翻译领域。此次会议还包括由 GRC 赞助的“power hour”活动，这将为大家提供一个平台 讨论妇女和其他代表性不足的少数群体在科学领域面临的挑战。作为第一个也是唯一一个 关于翻译与疾病的会议，这次会议将极大地影响参与者的理解 几个 NIH 机构感兴趣的几种主要疾病机制。本次会议提供了 研究者研究翻译的重要“翻译”场所。

Project Abstract Partial support is requested for the Translation Machinery in Health and Disease-Protein Synthesis and Cellular Synergy Gordon Research Seminar and Gordon Research Conference to be held in Galveston, Texas on February 19-24, 2023. It is the first and to our knowledge, the only, disease-focused, interdisciplinary meeting on mRNA translation. Unlike other conferences that mainly focus on the structure of the translational machinery and its function in protein synthesis, the focus of this GRC is on the role of translation in human disease and its alternations on pathological consequences. This unique conference provides a forum for scientists to discuss their findings with an ultimate long-term goal of building collaborations toward understanding and finding treatments for disease. The specific aims of the Gordon Research Conference are to convene 50 speakers and an additional 125-150 participants who are experts in the fields of neurological disease, stress and aging, cancer, infectious diseases, ribosomepathies, rare diseases, mitochondrial diseases and metabolic diseases to discuss basic science and therapeutic interventions. The accompanying Gordon Research Seminar will provide a forum for scientists in early stages of their career to present their research on translation and disease and networking activity. The invited speakers, other attendees, and early stage scientists will have many opportunities to talk to researchers in other areas of translation research, exchange ideas and concepts among different disciplines, and develop new collaborations. Dr. Susan Ackerman, an expert in translation aspect of neuroscience and neurodegeneration, and Dr. Jonathan Weissman, an expert in translation in human biology will give keynote lectures at the Gordon Research Conference, and Dr. Katrin Karbstein, an expert on ribosome assembly and function will give the keynote at the Gordon Research Seminar. In addition to invited speakers and speakers chosen from the abstracts, four poster sessions will enable all participants to contribute to the meeting. There will be many opportunities for young investigators, women, and minorities to interact with senior leaders in the translation field. The conference also includes a GRC-sponsored “power hour” which will provide a platform to discuss challenges that women and other underrepresented minorities face in science. As the first and only conference on translation and disease, this conference will significantly impact the participant's understanding of several major disease mechanisms that are of interest to several NIH institutions. This meeting provides a critical “translational” venue for investigators studying translation.