2023 Translation Machinery in Health and Disease GRC/GRS

2023 健康与疾病领域的翻译机器 GRC/GRS

• 批准号: 10604800
• 负责人: TAO PAN
• 金额: $ 2.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10604800
• 关键词: Academia; Aging; Amino Acyl-tRNA Synthetases; Area; Basic Science; Biological Process; Biology; Cancer Etiology; Chronic stress; Clinic; Collaborations; Communicable Diseases; Communication; Coupled; Dedications; Defect; Development; Discipline; Disease; Face; Faculty; Functional disorder; Goals; Health; Homeostasis; Hour; Human Biology; Immune System Diseases; Industry; Institution; Learning; Living Arrangement; Location; Malignant Neoplasms; Messenger RNA; Metabolic Diseases; Methodology; Minority; Mitochondrial Diseases; Modality; Nerve Degeneration; Neurosciences; Organism; Participant; Pathologic; Pathologic Processes; Postdoctoral Fellow; Process; Protein Biosynthesis; Proteins; Rare Diseases; Research; Research Personnel; Ribosomes; Role; Science; Scientist; Site; Stress; Structure; Technology; Texas; Therapeutic Intervention; Toxin; Transfer RNA; Translational Regulation; Translational Research; Translations; Underrepresented Minority; United States National Institutes of Health; Woman; acute stress; career; collaborative environment; genetic information; graduate student; human disease; interest; lectures; mRNA Translation; macromolecule; meetings; member; nervous system disorder; posters; response; social; symposium; synergism

Project Abstract Partial support is requested for the Translation Machinery in Health and Disease-Protein Synthesis and Cellular Synergy Gordon Research Seminar and Gordon Research Conference to be held in Galveston, Texas on February 19-24, 2023. It is the first and to our knowledge, the only, disease-focused, interdisciplinary meeting on mRNA translation. Unlike other conferences that mainly focus on the structure of the translational machinery and its function in protein synthesis, the focus of this GRC is on the role of translation in human disease and its alternations on pathological consequences. This unique conference provides a forum for scientists to discuss their findings with an ultimate long-term goal of building collaborations toward understanding and finding treatments for disease. The specific aims of the Gordon Research Conference are to convene 50 speakers and an additional 125-150 participants who are experts in the fields of neurological disease, stress and aging, cancer, infectious diseases, ribosomepathies, rare diseases, mitochondrial diseases and metabolic diseases to discuss basic science and therapeutic interventions. The accompanying Gordon Research Seminar will provide a forum for scientists in early stages of their career to present their research on translation and disease and networking activity. The invited speakers, other attendees, and early stage scientists will have many opportunities to talk to researchers in other areas of translation research, exchange ideas and concepts among different disciplines, and develop new collaborations. Dr. Susan Ackerman, an expert in translation aspect of neuroscience and neurodegeneration, and Dr. Jonathan Weissman, an expert in translation in human biology will give keynote lectures at the Gordon Research Conference, and Dr. Katrin Karbstein, an expert on ribosome assembly and function will give the keynote at the Gordon Research Seminar. In addition to invited speakers and speakers chosen from the abstracts, four poster sessions will enable all participants to contribute to the meeting. There will be many opportunities for young investigators, women, and minorities to interact with senior leaders in the translation field. The conference also includes a GRC-sponsored “power hour” which will provide a platform to discuss challenges that women and other underrepresented minorities face in science. As the first and only conference on translation and disease, this conference will significantly impact the participant's understanding of several major disease mechanisms that are of interest to several NIH institutions. This meeting provides a critical “translational” venue for investigators studying translation.

项目摘要 要求对健康和疾病蛋白质合成和细胞的翻译机制进行部分支持 Synergy Gordon Research研讨会和戈登研究会议将在德克萨斯州加尔维斯顿举行 2023年2月19日至24日。据我们所知，这是唯一的，以疾病为中心的跨学科会议 关于mRNA翻译。与其他主要集中于翻译机械结构的会议不同 及其在蛋白质合成中的功能，该GRC的重点是翻译在人类疾病及其中的作用 病理后果的替代方案。这个独特的会议为科学家提供了一个论坛来讨论 他们的发现具有建立合作的最终长期目标，以理解和寻找 疾病治疗。戈登研究会议的具体目的是方便50位发言人和 另外125-150名参与者是神经系统疾病，压力和衰老，癌症，，癌症领域的专家 传染病，核糖行为，罕见疾病，线粒体疾病和代谢疾病进行讨论 基础科学和治疗干预措施。参与的戈登研究研讨会将提供一个论坛 在职业生涯的早期阶段科学家介绍他们的翻译，疾病和网络研究 活动。受邀的演讲者，其他与会者和早期科学家将有很多机会与 不同学科之间翻译研究，交流思想和概念的其他领域的研究人员， 并开发新的合作。 Susan Ackerman博士，神经科学翻译方面的专家 NeuroDegeneration，以及人类生物学翻译专家Jonathan Weissman博士将提供主题演讲 戈登研究会议上的演讲，核糖体大会专家Katrin Karbstein博士和 功能将在戈登研究研讨会上提供主题演讲。除了被邀请的演讲者和演讲者 从摘要中进行选择，四个海报会议将使所有参与者能够为会议做出贡献。那里 对于年轻的调查人员，妇女和少数民族将是许多与高级领导人互动的机会 翻译字段。会议还包括一个由GRC赞助的“ Power Hour”，将为 讨论妇女和其他代表性不足的少数民族在科学领域面临的挑战。作为第一个也是唯一的 关于翻译和疾病的会议，这次会议将对参与者的理解产生重大影响 在几种NIH机构中感兴趣的几种主要疾病机制中。这次会议提供了 研究翻译的研究人员的关键“翻译”场所。