2023 Translation Machinery in Health and Disease GRC/GRS

项目摘要 健康与疾病中的翻译机制-蛋白质合成和细胞 协同戈登研究研讨会和戈登研究会议将在德克萨斯州加尔维斯顿举行， 2023年2月19日至24日。据我们所知，这是第一次也是唯一一次以疾病为重点的跨学科会议。 mRNA的翻译。与其他主要关注翻译机制结构的会议不同， 及其在蛋白质合成中的功能，本研究报告的重点是翻译在人类疾病中的作用及其 改变病理后果。这个独特的会议为科学家提供了一个讨论的论坛 他们的研究结果与最终的长期目标，建立合作，以了解和发现 疾病的治疗方法。戈登研究会议的具体目标是召集50名发言人， 另外125-150名参与者是神经系统疾病，压力和衰老，癌症， 传染病、核糖体病、罕见病、线粒体疾病和代谢性疾病进行讨论 基础科学和治疗干预。与此同时，戈登研究研讨会将提供一个论坛， 让处于职业生涯早期的科学家展示他们在翻译、疾病和网络方面的研究 活动受邀演讲者、其他与会者和早期科学家将有很多机会与之交谈 其他翻译研究领域的研究人员，在不同学科之间交流思想和概念， 发展新的合作。苏珊阿克曼博士，神经科学翻译方面的专家， 神经退行性疾病，以及人类生物学翻译专家Jonathan Weissman博士将发表主题演讲 戈登研究会议上的演讲，以及卡特琳·卡布斯坦博士，核糖体组装和 功能将在戈登研究研讨会上发表主题演讲。除了受邀的演讲者和演讲者 从摘要中选出的四场海报会议将使所有与会者都能对会议作出贡献。那里 年轻的调查人员，妇女和少数民族将有许多机会与高级领导人互动， 翻译领域。会议还包括一个由GRC赞助的“电力小时”，这将提供一个平台， 讨论妇女和其他代表性不足的少数群体在科学领域面临的挑战。作为第一个也是唯一一个 翻译和疾病的会议，这次会议将显着影响与会者的理解 几个主要的疾病机制，这是感兴趣的几个国家卫生研究院机构。本次会议提供了一个 关键的“翻译”场所研究翻译。

Project Abstract Partial support is requested for the Translation Machinery in Health and Disease-Protein Synthesis and Cellular Synergy Gordon Research Seminar and Gordon Research Conference to be held in Galveston, Texas on February 19-24, 2023. It is the first and to our knowledge, the only, disease-focused, interdisciplinary meeting on mRNA translation. Unlike other conferences that mainly focus on the structure of the translational machinery and its function in protein synthesis, the focus of this GRC is on the role of translation in human disease and its alternations on pathological consequences. This unique conference provides a forum for scientists to discuss their findings with an ultimate long-term goal of building collaborations toward understanding and finding treatments for disease. The specific aims of the Gordon Research Conference are to convene 50 speakers and an additional 125-150 participants who are experts in the fields of neurological disease, stress and aging, cancer, infectious diseases, ribosomepathies, rare diseases, mitochondrial diseases and metabolic diseases to discuss basic science and therapeutic interventions. The accompanying Gordon Research Seminar will provide a forum for scientists in early stages of their career to present their research on translation and disease and networking activity. The invited speakers, other attendees, and early stage scientists will have many opportunities to talk to researchers in other areas of translation research, exchange ideas and concepts among different disciplines, and develop new collaborations. Dr. Susan Ackerman, an expert in translation aspect of neuroscience and neurodegeneration, and Dr. Jonathan Weissman, an expert in translation in human biology will give keynote lectures at the Gordon Research Conference, and Dr. Katrin Karbstein, an expert on ribosome assembly and function will give the keynote at the Gordon Research Seminar. In addition to invited speakers and speakers chosen from the abstracts, four poster sessions will enable all participants to contribute to the meeting. There will be many opportunities for young investigators, women, and minorities to interact with senior leaders in the translation field. The conference also includes a GRC-sponsored “power hour” which will provide a platform to discuss challenges that women and other underrepresented minorities face in science. As the first and only conference on translation and disease, this conference will significantly impact the participant's understanding of several major disease mechanisms that are of interest to several NIH institutions. This meeting provides a critical “translational” venue for investigators studying translation.