Chemoprevention and mechanisms of obesity-promoted pancreatic adenocarcinoma

项目总结 项目资助：肥胖促进胰腺的化学预防及其机制 腺癌“构成了一个高度协作的多学科研究计划，旨在使 对肥胖在胰腺癌发生发展中的研究有重大影响。一个详细的 了解肥胖在胰腺癌发生中的生物学作用机制可以形成 以生物为基础的实践、以科学为基础的建议和干预策略的理论基础 在预防这种疾病方面。该计划项目包括来自加州大学洛杉矶分校和雪松的专业知识 西奈医疗中心。该项目由经验丰富的胰腺癌研究人员领导，他们组织了 调查团队开发高度互动和协同的研究方案。我们的目标是研究 肥胖促进胰腺癌发展的机制，并探索介入性、癌症- 预防策略。创新的动物和细胞培养模型和新概念得到了 提出了丰富的初步数据。这些项目将集中在：肥胖的脂肪组织炎症- 促进胰腺癌(项目1)；降脂和化疗预防胰腺癌 抗糖尿病药物(项目2)：胰腺纤维炎症微环境在肥胖中的作用 促进胰腺癌(项目3)。这些项目将利用行政核心(包括生物统计分项)。 核心)和共享资源核心，即动物和细胞模型核心(带有病理学分核心)。一个外部的 由国内和国际公认的转移性胰腺癌组成的咨询委员会 调查人员和倡导者已经聚集在一起。该计划项目旨在实现最大程度的集成 以及研究和关键调查人员的协同作用，他们已经合作了12年以上，因此 建议的计划可以专注于最有前途、最具翻译潜力的研究 和冲击力。

PROJECT SUMMARY The Program Project Grant “Chemoprevention and mechanisms of obesity-promoted pancreatic adenocarcinoma” constitutes a highly collaborative, multidisciplinary research program designed to make a significant impact on the investigation of obesity in the development of pancreatic cancer. A detailed understanding of the biological mechanisms of action of obesity on pancreatic cancer development can form the rationale for biologically-based practices, scientifically-founded recommendations and interventional strategies in the prevention of this disease. The Program Project includes expertise from the UCLA campus and Cedars Sinai Medical Center. The Program is led by experienced pancreatic cancer researchers, who have organized investigative teams to develop highly interactive and synergistic research programs. The goal is to study the mechanisms, by which obesity promotes pancreatic cancer development and to explore interventional, cancer- preventing strategies. Innovative animal and cell culture models and novel concepts strongly supported by a wealth of preliminary data are proposed. The Projects will focus on: Adipose tissue inflammation in obesity- promoted pancreatic cancer (Project 1); Chemoprevention of pancreatic cancer with lipid-lowering and antidiabetic agents (Project 2); Role of the pancreatic fibro-inflammatory microenvironment in obesity- promoted pancreatic cancer (Project 3). The projects will utilize an Administrative Core (with Biostatistics Sub- Core) and a Shared Resource Core, the Animal and Cell Models Core (with Pathology Sub-Core). An External Advisory Board comprised of nationally and internationally recognized translational pancreatic cancer investigators and advocates has been assembled. The Program Project is designed for maximum integration and synergy of research and key investigators, who have been collaborating for more than 12 years so that the proposed Program can be focused on the most promising investigations with the greatest translational potential and impact.