Chemoprevention and mechanisms of obesity-promoted pancreatic adenocarcinoma

项目摘要 肥胖促进胰腺癌的化学预防和机制 腺癌”构成了一个高度合作的，多学科的研究计划，旨在使一个 肥胖在胰腺癌发生发展中的研究具有重要影响。详细 了解肥胖对胰腺癌发展的生物学作用机制， 基于生物学的实践、有科学依据的建议和干预策略的依据 在预防这种疾病。该计划项目包括来自加州大学洛杉矶分校校园和雪松的专业知识 西奈医疗中心。该计划由经验丰富的胰腺癌研究人员领导，他们组织了 研究团队开发高度互动和协同的研究计划。目标是研究 机制，肥胖促进胰腺癌的发展，并探索干预，癌症- 预防战略。创新的动物和细胞培养模型和新颖的概念得到了 提出了丰富的初步数据。该项目将重点关注：肥胖症中的脂肪组织炎症- 促进胰腺癌（项目1）;化学预防胰腺癌与降脂和 抗糖尿病药物（项目2）;胰腺纤维炎症微环境在肥胖中的作用- 促进胰腺癌（项目3）。这些项目将利用一个行政核心（与生物统计小组， 核心）和共享资源核心，动物和细胞模型核心（病理学子核心）。外部 由国家和国际公认的转化性胰腺癌组成的咨询委员会 调查人员和辩护律师已经聚集。该计划项目旨在最大限度地整合 以及研究和主要研究人员的协同作用，他们已经合作了12年多， 拟议的计划可以集中在最有前途的研究与最大的翻译潜力 和影响。

PROJECT SUMMARY The Program Project Grant “Chemoprevention and mechanisms of obesity-promoted pancreatic adenocarcinoma” constitutes a highly collaborative, multidisciplinary research program designed to make a significant impact on the investigation of obesity in the development of pancreatic cancer. A detailed understanding of the biological mechanisms of action of obesity on pancreatic cancer development can form the rationale for biologically-based practices, scientifically-founded recommendations and interventional strategies in the prevention of this disease. The Program Project includes expertise from the UCLA campus and Cedars Sinai Medical Center. The Program is led by experienced pancreatic cancer researchers, who have organized investigative teams to develop highly interactive and synergistic research programs. The goal is to study the mechanisms, by which obesity promotes pancreatic cancer development and to explore interventional, cancer- preventing strategies. Innovative animal and cell culture models and novel concepts strongly supported by a wealth of preliminary data are proposed. The Projects will focus on: Adipose tissue inflammation in obesity- promoted pancreatic cancer (Project 1); Chemoprevention of pancreatic cancer with lipid-lowering and antidiabetic agents (Project 2); Role of the pancreatic fibro-inflammatory microenvironment in obesity- promoted pancreatic cancer (Project 3). The projects will utilize an Administrative Core (with Biostatistics Sub- Core) and a Shared Resource Core, the Animal and Cell Models Core (with Pathology Sub-Core). An External Advisory Board comprised of nationally and internationally recognized translational pancreatic cancer investigators and advocates has been assembled. The Program Project is designed for maximum integration and synergy of research and key investigators, who have been collaborating for more than 12 years so that the proposed Program can be focused on the most promising investigations with the greatest translational potential and impact.