Chemoprevention and mechanisms of obesity-promoted pancreatic adenocarcinoma

肥胖促进的胰腺癌的化学预防和机制

• 批准号: 10605224
• 负责人: Guido Erwin Michael Eibl
• 金额: $ 112.28万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10605224
• 关键词: Adipose tissue; Advocate; Animal Model; Animals; Anti-Inflammatory Agents; Antidiabetic Drugs; Biological; Biometry; Cell Culture Techniques; Cell model; Chemoprevention; Clinical; Collaborations; Complex; Data; Development; Diabetes Mellitus; Dietary Component; Disease; Event; Excision; Genetic; Genetic Engineering; Goals; Growth; Health Promotion; Inflammation; Intercept; Interdisciplinary Study; International; Intervention; Intervention Studies; Investigation; Lipids; Malignant Neoplasms; Malignant neoplasm of pancreas; Medical center; Metformin; Modeling; Mutate; Obesity; Pancreas; Pancreatic Adenocarcinoma; Pathology; Patient Care; Patients; Prevention strategy; Preventive; Primary Prevention; Program Research Project Grants; Recommendation; Research; Research Personnel; Resource Sharing; Risk; Role; Secondary Prevention; Signal Transduction; Tumor Promotion; Tumor-associated macrophages; cancer prevention; chronic pancreatitis; clinical practice; design; diet-induced obesity; disorder prevention; experience; high risk; innovation; insight; novel; obese patients; pancreas development; pancreatic stellate cell; prevent; programs; synergism; translational impact; translational potential; tumor

PROJECT SUMMARY The Program Project Grant “Chemoprevention and mechanisms of obesity-promoted pancreatic adenocarcinoma” constitutes a highly collaborative, multidisciplinary research program designed to make a significant impact on the investigation of obesity in the development of pancreatic cancer. A detailed understanding of the biological mechanisms of action of obesity on pancreatic cancer development can form the rationale for biologically-based practices, scientifically-founded recommendations and interventional strategies in the prevention of this disease. The Program Project includes expertise from the UCLA campus and Cedars Sinai Medical Center. The Program is led by experienced pancreatic cancer researchers, who have organized investigative teams to develop highly interactive and synergistic research programs. The goal is to study the mechanisms, by which obesity promotes pancreatic cancer development and to explore interventional, cancer- preventing strategies. Innovative animal and cell culture models and novel concepts strongly supported by a wealth of preliminary data are proposed. The Projects will focus on: Adipose tissue inflammation in obesity- promoted pancreatic cancer (Project 1); Chemoprevention of pancreatic cancer with lipid-lowering and antidiabetic agents (Project 2); Role of the pancreatic fibro-inflammatory microenvironment in obesity- promoted pancreatic cancer (Project 3). The projects will utilize an Administrative Core (with Biostatistics Sub- Core) and a Shared Resource Core, the Animal and Cell Models Core (with Pathology Sub-Core). An External Advisory Board comprised of nationally and internationally recognized translational pancreatic cancer investigators and advocates has been assembled. The Program Project is designed for maximum integration and synergy of research and key investigators, who have been collaborating for more than 12 years so that the proposed Program can be focused on the most promising investigations with the greatest translational potential and impact.

项目概要 项目资助“肥胖促进胰腺癌的化学预防和机制” 腺癌”构成了一个高度协作的多学科研究项目，旨在使 肥胖在胰腺癌发生过程中的研究具有重大影响。详细的 了解肥胖对胰腺癌发展的生物学作用机制可以形成 基于生物学的实践、有科学依据的建议和干预策略的基本原理 在预防这种疾病方面。该计划项目包括来自加州大学洛杉矶分校校园和 Cedars 的专业知识 西奈医疗中心。该计划由经验丰富的胰腺癌研究人员领导，他们组织了 研究团队开发高度互动和协同的研究计划。目标是研究 肥胖促进胰腺癌发生的机制，并探索介入、癌症治疗 预防策略。创新的动物和细胞培养模型和新颖的概念得到了强有力的支持 提出了大量的初步数据。该项目将重点关注： 肥胖症中的脂肪组织炎症 - 促进胰腺癌（项目1）；降脂和降脂等化学预防胰腺癌 抗糖尿病药物（项目2）；胰腺纤维炎症微环境在肥胖中的作用 促进胰腺癌（项目 3）。这些项目将利用行政核心（以及生物统计子系统） 核心）和共享资源核心、动物和细胞模型核心（带有病理学子核心）。外部 顾问委员会由国内和国际公认的转化胰腺癌专家组成 调查人员和倡导者已经集合。该计划项目旨在实现最大程度的集成 以及研究和主要研究人员的协同作用，他们已经合作了 12 年多，以便 拟议的计划可以专注于最有前途且具有最大转化潜力的研究 和影响。