Targeting diet-induced promotion of Kras-initiated pancreatic adenocarcinoma

针对饮食诱导的 Kras 引发的胰腺癌的促进作用

• 批准号: 8337028
• 负责人: Guido Erwin Michael Eibl
• 金额: $ 125.35万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8337028
• 关键词: Advocate; Alcohol abuse; Animal Model; Animals; Antidiabetic Drugs; Autophagocytosis; Biological; Biometry; Calories; Cell Culture Techniques; Chemoprevention; Clinical; Data; Development; Diet; Dietary Factors; Disease; Engineering; Environment; Event; Fatty acid glycerol esters; Fish Oils; Genetic; Goals; Growth; Health; Health Promotion; Healthcare Systems; Inflammatory; Interdisciplinary Study; Intervention; Investigation; Lead; Link; Los Angeles; Malignant Neoplasms; Malignant neoplasm of pancreas; Metabolic syndrome; Metformin; Modeling; Mutate; National Cancer Institute; Obesity; Pancreas; Pancreatic Adenocarcinoma; Pathology; Patient Care; Prevention strategy; Process; Program Research Project Grants; Reactive Oxygen Species; Recommendation; Research; Research Personnel; Resources; Risk; Role; Series; base; cancer prevention; carcinogenesis; clinical practice; design; dietary supplements; disorder prevention; experience; innovation; insight; mitochondrial dysfunction; neglect; novel; pancreatic tumorigenesis; prevent; programs; stellate cell; tumor

DESCRIPTION (provided by applicant): The Program Project Grant "Targeting diet-induced promotion of Kras-initiated pancreatic adenocarcinoma" constitutes a highly collaborative, multidisciplinary research program designed to make a significant impact on the investigation of diet in the development of pancreatic cancer. A detailed understanding of the biological mechanisms of action of a typical Western-style diet, rich in fats and calories, on pancreatic cancer development can form the rationale for biologically-based practices and scientifically-founded dietary recommendations in the prevention of this disease. Our Program Project includes expertise from the UCLA campus and VA Greater Los Angeles Healthcare System - West Los Angeles (VAGLAHS-WLA). The Program is led by experienced pancreatic cancer researchers, who have organized investigative teams to develop highly interactive and synergistic research programs. Our goal is to study the mechanisms, by which a Western-style diet, rich in fats and calories, promotes pancreatic cancer development and to explore interventional, cancer-preventing strategies. Innovative animal and cell culture models and novel concepts strongly supported by a wealth of preliminary data are proposed. The Projects will focus on: Inflammatory processes in diet-induced pancreatic cancer promotion (Project 1); Chemoprevention of pancreatic cancer with antidiabetic agents (Project 2); Inefficient autophagy, mitochondrial dysfunction, and pancreatic tumorigenesis (Project 3); Alcohol abuse and metabolic syndrome promote desmoplasia of pancreatic cancer (Project 4). The projects will utilize our Shared Core Resources including the Administrative Core (with Biostatistics Sub-Core) and the Animal Core (with Pathology Sub-Core). An External Advisory Board comprised of nationally and internationally recognized translational pancreatic cancer investigators and advocates has been assembled. The Program Project is designed for maximum integration and synergy of research and key investigators, who have been collaborating over the years so that the proposed Program can be focused on the most promising investigations with the greatest translational potential and impact.

描述（由申请人提供）：计划项目资助“靶向饮食诱导促进Kras启动的胰腺癌”构成了一个高度合作的多学科研究计划，旨在对饮食在胰腺癌发展中的研究产生重大影响。详细了解典型的西式饮食（富含脂肪和热量）对胰腺癌发展的生物学作用机制，可以为预防这种疾病的生物学实践和科学饮食建议提供理论基础。我们的计划项目包括来自加州大学洛杉矶分校校园和VA大洛杉矶医疗保健系统-西洛杉矶（VAGLAHS-WLA）的专业知识。该计划由经验丰富的胰腺癌研究人员领导，他们组织了调查团队，以开发高度互动和协同的研究计划。我们的目标是研究富含脂肪和热量的西式饮食促进胰腺癌发展的机制，并探索干预性的癌症预防策略。创新的动物和细胞培养模型和新的概念提出了大量的初步数据的有力支持。这些项目将侧重于：饮食诱导的胰腺癌促进中的炎症过程（项目1）;抗糖尿病药物对胰腺癌的化学预防（项目2）;低效自噬、线粒体功能障碍和胰腺肿瘤发生（项目3）;酒精滥用和代谢综合征促进胰腺癌的结缔组织增生（项目4）。这些项目将利用我们的共享核心资源，包括行政核心（生物统计子核心）和动物核心（病理子核心）。一个由国内和国际公认的转化胰腺癌研究者和倡导者组成的外部咨询委员会已经成立。该计划项目旨在最大限度地整合和研究和主要研究人员的协同作用，他们多年来一直在合作，以便拟议的计划可以集中在最有前途的调查，具有最大的转化潜力和影响。