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Improved Motion Robust MRI of Children

改进儿童运动鲁棒性 MRI

基本信息

批准号：
10605154
负责人：
SIMON K WARFIELD
金额：
$ 57.65万
依托单位：
BOSTON CHILDREN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-07-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10605154
关键词：
3-Dimensional 8 year old Address Adverse event Algorithms Anesthesia procedures Caring Cephalometry Child Childhood Clinical Compensation Consumption Data Diagnosis Diagnostic Diagnostic Imaging Disease Equation Frustration Goals Grant Head Head Movements Image Imaging Techniques Imaging technology Instruction Life Magnetic Resonance Imaging Measurement Measures Methods Modeling Monitor Morphologic artifacts Motion Patients Physiological Population Positioning Attribute Process Radial Radiology Specialty Research Resort Risk Sampling Scanning Schedule Sedation procedure Series Serious Adverse Event Signal Transduction Source Speed Techniques Technology Testing Time United States National Institutes of Health Update Variant anatomic imaging brain magnetic resonance imaging clinical imaging clinical practice cohort cost diagnostic value efficacy evaluation experimental study image reconstruction imaging modality improved innovation interest magnetic field novel older patient prospective quantitative imaging reconstruction recruit response side effect simulation spatial relationship spatiotemporal success translational impact verbal volunteer

项目摘要

Project Summary Magnetic resonance imaging (MRI) is critically important for pediatric care. However, patient motion significantly limits our ability to produce high-quality images in young children who may be unable to respond well to verbal instructions and who have difficulty remaining still inside the scanner. Head motion during MRI disrupts spatial encoding and leads to data loss, generating a range of artifacts in the images, which hinders diagnostic utility. Thus, sedation and anesthesia are routinely used in pediatric populations; however, these practices are associated with severe adverse events and are extremely time-consuming and costly to administer. Unfortunately, current state-of-the-art motion compensation technologies are not fast or accurate enough to adequately compensate for large and frequent head movements in uncooperative children, or require external hardware, which is far from ideal for clinical workflow. Under the previous grant period, we made significant progress towards our overarching goal of improved motion-robust pediatric MRI by successfully developing a new markerless motion tracking approach utilizing free induction decay (FID) navigators and novel algorithms to generate diagnostic images from small periods of motion-free time. The goal of the research proposed under this renewed application to the NIH is two-fold: 1) to continue to develop and refine novel markerless technologies for motion measurement and correction to enable high-quality MRI in the presence of large, frequent motion and 2) to evaluate these technologies for improving the quality and success rate of pediatric MRI without the use of sedation and anesthesia. We hypothesize that improving the accuracy of FID navigator motion measurements, and the extent and speed of our correction algorithms, will successfully compensate for sources of persistent artifacts in the images. To achieve these ambitious goals, we propose to undertake the following Specific Aims over the 5-year period of requested support: 1) develop and evaluate an extended model that can, for the first time, simultaneously measure head motion and induced magnetic field changes using FID navigators; 2) develop and evaluate a novel self-navigated 3D radial acquisition with augmented reconstruction for retrospective correction of motion, and induced magnetic field and coil sensitivity variations; 3) develop and evaluate prospective motion correction and dynamic shimming utilizing real-time motion and field measurements to produce artifact-free images; and 4) apply and evaluate these highly innovative motion compensation techniques for imaging 0–8 year old patients without the use of sedation. The motion-robust imaging technologies proposed in this application can be easily deployed in clinical settings with widely-available, standard MRI hardware, and are therefore expected to have rapid translational impact for the countless pediatric diseases and disorders presently evaluated by MRI. The ability to image young children without the use of sedation and anesthesia will dramatically decrease the time, cost and risk involved in generating diagnostically useful images with MRI.

项目摘要磁共振成像(MRI)是至关重要的儿科护理。然而，耐心的动议极大地限制了我们在幼儿身上产生高质量图像的能力，这些幼儿可能无法做出反应好的，口头指示和那些在扫描仪内保持不动的人。磁共振成像过程中的头部运动扰乱空间编码并导致数据丢失，从而在图像中生成一系列伪像，这阻碍了诊断实用程序。因此，镇静和麻醉在儿科人群中是常规使用的；然而，这些实践与严重的不良事件相关，并且极其耗时且代价高昂管理。不幸的是，当前最先进的运动补偿技术既不快也不准确足以充分补偿不合作儿童的大而频繁的头部运动，或者需要外部硬件，这远远不是临床工作流程的理想选择。在上一个授权期内，我们取得了重大进展，我们的总体目标，改善运动健壮的儿科核磁共振成功地开发了一种新的利用自由感应衰减(FID)的无标记运动跟踪方法导航器和新的算法，可从较小的非运动时间段生成诊断图像。这个根据这一新的申请，NIH提出的研究目标有两个：1)继续开发并改进用于运动测量和校正的新型无标记技术，以实现高质量的MRI 存在大的、频繁的运动，以及2)评估这些技术以提高质量和不使用镇静剂和麻醉剂的儿童MRI成功率。我们假设，改善 FID导航仪运动测量的准确性，以及我们校正算法的范围和速度，将成功补偿图像中持久伪影的来源。为了实现这些雄心勃勃的目标，我们建议在请求支持的5年期间实现以下具体目标：1)开发并首次评估了一种扩展模型，该模型可以同时测量头部运动和诱导使用FID导航仪的磁场变化；2)开发和评估一种新型的自导航3D径向具有增强重建的采集，用于运动和感应磁场的回溯校正和线圈灵敏度变化；3)开发和评估预期的运动校正和动态垫片利用实时运动和现场测量来产生无伪影图像；以及4)应用和评估这些高度创新的运动补偿技术为0-8岁的患者提供了无需使用镇静剂。此应用程序中建议的运动稳健成像技术可以轻松部署在具有广泛可用的标准MRI硬件的临床环境，因此预计将具有快速目前通过核磁共振对无数儿科疾病和障碍的翻译影响进行评估。一种能力在不使用镇静和麻醉的情况下想象幼儿将极大地减少时间、成本以及使用MRI生成诊断有用图像所涉及的风险。