NIH Chemical Genomics Center

在报告的一年中，NCGC与世界各地的100多名研究人员合作，并在这一年中对分子靶点和细胞表型进行了50多次高通量筛选，这些分子靶点和细胞表型对几乎所有生物学和疾病领域都很重要，包括癌症、心脏病、传染病和神经疾病。对这些不同的生物发现了30多个新的化学探针，NCGC的科学家在08财年发表了20多份出版物。其中包括治疗寄生虫病的新化合物，新的磷酸二酯酶-4抑制剂，首次报道的促甲状腺激素激动剂，以及改变癌症基因表达的化合物。总体而言，生产指标包括筛选&gt；5000万口复合井，产生&gt；2亿个数据点，以及将&gt；3亿个数据字段存入PubChem。 NCGC在这一年中扩大了其已经广泛的推广计划，以教育学术界关于化学基因组学方法和能力，并帮助研究人员进行分析开发工作。NCGC的工作人员在这一年里在世界各地举办了50多场特邀讲座，从纽约、旧金山到日本、德国和英国。 在这一年中，NCGC还成功地与全美各地的化学探针开发中心竞争下一阶段的分子图书馆路线图资助，获得了所有申请者中的最高分。

During the reporting year, the NCGC worked with over 100 researchers worldwide, and during the year performed over 50 high-throughput screens on molecular targets and cellular phenotypes important for virtually every area of biology and disease, including cancer, heart disease, infectious diseases, and neurological disorders. Over 30 new chemical probes of these diverse biologies were discovered, and NCGC scientists published over 20 publications during FY08. Among these were new compounds to treat the parasitic disease Schistosomiasis, new phosphodiesterase-4 inhibitors, the first reported thyroid stimulating hormone agonists, and compounds to modify gene expression in cancer. In all, production metrics included >50,000,000 compound wells screened, >200 million data points generated, and >300,000,000 data fields deposited into PubChem. The NCGC expanded its already-extensive outreach program during the year, in order to both educate the academic community about chemical genomics methods and capabilities, and assist researchers in their assay development efforts. NCGC staff delivered over 50 invited lectures worldwide during the year, from New York and San Francisco to Japan, Germany, and the U.K. During the year, the NCGC also successfully competed with chemical probe development centers all across the U.S. for the next phase of Molecular Libraries Roadmap funding, garnering the highest score of all applicants.