Novel treatments of fibrosis for hypertensive heart disease

高血压心脏病纤维化的新疗法

• 批准号: nhmrc : 1127792
• 负责人: Prof Kate Denton
• 金额: $ 62.35万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/novel-treatments-fibrosis-heart-disease/948067
• 关键词: Novel; treatments; fibrosis; hypertensive; heart

A recognised risk factor for cardiovascular disease is high blood pressure which contributes to a stiffer heart that can ultimately lead to heart failure. There are very few treatments that can reduce heart stiffening, called fibrosis. This project is focused on the preclinical testing of novel compounds that we have developed to reverse the build-up of fibrosis in the heart, which will lead to better treatment of elderly patients with high blood pressure and poorly-functioning hearts.

心血管疾病的一个公认的危险因素是高血压，这会导致心脏僵硬，最终导致心力衰竭。很少有治疗方法可以减少心脏硬化，称为纤维化。该项目的重点是对我们开发的用于逆转心脏纤维化的新型化合物进行临床前测试，这将有助于更好地治疗高血压和心脏功能不良的老年患者。