Renal AT2R are a therapeutic target for the treatment of hypertension in women

肾 AT2R 是治疗女性高血压的治疗靶点

• 批准号: nhmrc : 606652
• 负责人: Prof Kate Denton
• 金额: $ 40.4万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/renal-at2r-therapeutic-hypertension-women/99512
• 关键词: Renal; AT2R; therapeutic; target; treatment

Being female is associated with better renal function, resistenace to renal injury and hypertension, but it is not understood why. Our work demonstrates that women have more angiotensin type 2 receptors (AT2R) in the kidney then men. In men AT2R have been suggested to protect against hypertension and renal damage. We predict that the effects of AT2R stimulation will be greater in women and therefore the protective benefits greater.

女性与更好的肾功能、对肾脏损伤和高血压的抵抗力有关，但原因尚不清楚。我们的工作表明，女性肾脏中的血管紧张素2型受体(AT2R)比男性更多。在男性中，AT2R被认为可以预防高血压和肾脏损害。我们预测AT2R刺激对女性的影响会更大，因此保护作用也会更大。