DEFINING NONCLASSICAL ANGIOTENSIN SIGNALLING AND CARDIOVASCULAR FUNCTION

定义非经典血管紧张素信号传导和心血管功能

• 批准号: nhmrc : 1045848
• 负责人: Prof Kate Denton
• 金额: $ 42.31万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-nonclassical-angiotensin-cardiovascular-function/111795
• 关键词: DEFINING; NONCLASSICAL; ANGIOTENSIN; SIGNALLING; CARDIOVASCULAR

Angiotensin II is a hormone which is well known to contribute to high blood pressure and cardiovascular disease. This proposal will use highly novel compounds that we have synthesised that, for the first time, selectively target nonclassical angiotensin-related binding sites, so called NON-AT1 receptors, which are thought to counteract the deleterious effects of angiotensin II that normally causes fibrosis or scarring of the heart which damages healthy muscle.

血管紧张素II是一种荷尔蒙，众所周知，它会导致高血压和心血管疾病。这项提议将使用我们合成的高度新颖的化合物，这些化合物首次选择性地针对非经典的血管紧张素相关结合部位，即所谓的非AT1受体，这些受体被认为可以抵消血管紧张素II的有害影响，血管紧张素II通常会导致心脏纤维化或结疤，损害健康的肌肉。