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Pathogenesis of Glaucomatous Optic Nerve Damage

青光眼视神经损伤的发病机制

基本信息

批准号：
7525618
负责人：
Harry Alan Quigley
金额：
$ 58.56万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1977
资助国家：
美国
起止时间：
1977-08-01 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7525618
关键词：
1 year old 1-Phosphatidylinositol 3-Kinase 3-Dimensional Accounting Acepromazine Active Sites Acute Adopted Adult Adverse effects Affect African Age Age-Months Air Algorithms Amacrine Cells Amiloride Amyloid beta-Protein Precursor Anatomy Anesthesia procedures Animals Anisotropy Annexins Anterior Antibodies Aorta Apoptosis Apoptotic Appearance Area Astrocytes Atlases Attenuated Autoantibodies Award Axon Axonal Transport Back Behavior Biochemical Biological Assay Biological Preservation Biomechanics Birth Blood Pressure Blood Vessels Blood capillaries Blood flow Body Temperature Brain Brain-Derived Neurotrophic Factor Breeding Buffers Burr hole procedure CCAAT-Enhancer-Binding Proteins Caliber Calibration Candidate Disease Gene Cannulas Cannulations Cattle Cell Count Cell Death Cell Nucleus Cell Survival Cell Therapy Cell physiology Cells Cellular Morphology Cellular Structures Ceruloplasmin Cessation of life Characteristics Chemicals Choroid Chronic Ciliary Body Ciliary Neurotrophic Factor Classification Clinical Code Collagen Collagen Fibril Collagen Gene Collagen Type I Companions Complementary DNA Complex Computer software Confocal Microscopy Connective Tissue Connective Tissue Alteration Copaxone Cornea Crush Injury Cryopreservation Cryoultramicrotomy Cytolysis Cytoprotection Data Data Collection Defect Dendrites Deterioration Development Devices Diastolic blood pressure Digoxigenin Dimensions Distal Doctor of Philosophy Dose Drops Dyes Dynein ATPase Economic Inflation Edetic Acid Ehlers-Danlos Syndrome Elastin Elastin Fiber Elements Endothelin Endothelin Receptor Engineering England European Evaluation Event Excision Exfoliation Syndrome Exhibits Exposure to Expressed Sequence Tags Eye Eye Banks FBN1 FOS gene Failure Family suidae Feedback Ferritin Fiber Fibrillar Collagen Fibroblasts Film Fluorescence Fluorochrome Freezing Frozen Sections Funding Ganglion Cell Layer Gene Activation Gene Cluster Gene Expression Gene Mutation Genes Glass Glaucoma Glues Glyceraldehyde Grant Graph Gray unit of radiation dose Growth Growth Factor Hand Head Heat shock proteins Height High Prevalence Histocytochemistry Homozygote Hour Human Human body Hydration status Hydrophthalmos Image Image Analysis Immediate-Early Genes Immunoblotting Immunofluorescence Immunologic Immunohistochemistry In Situ In Situ Hybridization In Vitro Inbred Strain Incidence India ink stain Indium Individual Induced Mutation Infant Inferior Inflammation Inflammatory Injection of therapeutic agent Injury Inner Nuclear Layer Investigation Investments JUN gene Jaw Keratoconus Ketamine Knock-out Knockout Mice Label Laboratories Lasers Lateral Geniculate Body Lead Left Length Leucine Life Light Link Liquid substance Location Long-Term Effects Losartan MAPK10 gene MAPK14 gene MAPK8 gene Maintenance Manuscripts Maps Marfan Syndrome Masks Matrix Metalloproteinases Measurable Measurement Measures Mechanics Mediating Mediator of activation protein Medical Technology Membrane Meridians Messenger RNA Methodology Methods Microscope Microscopic Microspheres Mitogen-Activated Protein Kinases Modeling Molecular Molecular Structure Monitor Monkeys Morphology Motor Mouse Protein Mouse Strains Movement Multivariate Analysis Mus Muscle Mutant Strains Mice Mutate Mutation Mydriasis Myopia Names Natural regeneration Needles Nerve Nerve Crush Nerve Degeneration Nerve Fibers Nerve Growth Factor Receptors Nerve Tissue Neurites Neurofilament-H Neuroglia Neurons Neurosciences Research Neurotransmitters Normal saline Nuclear Obstruction Ocular Hypertension Open-Angle Glaucoma Operative Surgical Procedures Ophthalmoscopy Optic Disk Optic Nerve Optic Nerve Injuries Optic Nerve Transections Optics Organelles Oryctolagus cuniculus Osmium Outcome Outcome Measure Outcome Study Paper Partner in relationship Pathogenesis Pathway interactions Pattern Peer Review Perfusion Peripheral Permeability Peroxidases Persons Pharmaceutical Preparations Phase Phenotype Phenylephrine Phosphorylation Physiologic Intraocular Pressure Physiological Physiology Polyethylenes Polystyrenes Positioning Attribute Predisposition Presynaptic Terminals Prevalence Preventive Primates Process Production Progress Reports Property Protease Inhibitor Protein Dephosphorylation Protein Kinase C Protein-Lysine 6-Oxidase Proteins Protocols documentation Publications Publishing Pump Pyroxylin RNA Radial Radioactive Ramp Rattus Reaction Reading Recovery Relative (related person)Relaxation Reporting Research Research Design Research Personnel Resolution Retina Retinal Retinal Ganglion Cells Reverse Transcription Riboflavin Ribonucleases Riluzole Risk Risk Factors Rodent Role Sagittaria Saline Sample Size Sampling Scaffolding Protein Scintillation Counter Scintillation Counting Sclera Secure Sedation procedure Serum Side Signal Pathway Signal Transduction Simulate Site Skin Slide Sodium Dodecyl Sulfate-PAGE Solutions Source Specific qualifier value Specimen Spottings Staging Staining method Stains Stem cells Stress Stress Tests Stretching Structure Subgroup Sucrose Suggestion Supravalvular aortic stenosis Surface Surgical incisions Syringes TNF gene TRAAK channel Tail Techniques Technology Temperature Tendon structure Testing Theoretical model Therapeutic Thick Three-dimensional analysis Thromboplastin Thrombospondin 1 Time Tissue Model Tissue Sample Tissues To specify Tolonium chloride Toxic effect Transducers Transferrin Transforming Growth Factor beta Transgenic Mice Transgenic Organisms Translating Translations Transmission Electron Microscopy Travel Trees Trephine hole Tropicamide Tropoelastin Tumor Necrosis Factor-alpha Tumor Necrosis Factors Tupaiidae Ultraviolet Rays Up-Regulation Vaccination Variant Vial device Visual Fields Visual Pathways Wallerian Degeneration Western Blotting Wood material Work Xylazine active control adeno-associated viral vector aerobic respiration control protein aggrecan anterior chamber anterograde transport base biglycan bone cDNA Arrays cDNA Library calbindin calbindin-D28K capillary cell injury cellular engineering central retinal artery comparative computerized data processing congenic connective tissue development crosslink cyclin D2 cytokine density design digital digital imaging dynactin experience fibrillin fibromodulin fluorescence microscope ganglion cell gene therapy high intraocular pressure horizontal cell human disease imaging modality improved in vivo inhibitor/antagonist injured instrument interest killings laser capture microdissection lectures lens lumican mRNA Expression mature animal microsystems morphometry mouse model mutant myocilin neonatal human nestin protein neurofilament neuroinflammation neuronal cell body neurotrophic factor neutralizing antibody novel overexpression paraform particle pressure prevent primary outcome programs promoter protective effect rat genome regional difference relating to nervous system research study response response to injury restoration retinal damage retinal neuron retrograde transport secondary outcome stress-activated protein kinase 1 success superior colliculus Corpora quadrigemina syntaxin trait transcription factor transmission process two-dimensional validation studies

项目摘要

To reduce the project to a 2 year proposal, I have retained the overall theme which is to study the effect of connective tissues of the sclera and peripapillary nerve head on axonal injury and RGC death. The portions of the 5 year proposal that were eliminated were much of former Aim 2 and 3 which dealt with studies of nerve head capillary function, and the roles of endothelin and tumor necrosis factor _ in RGC injury. We expect to test the role of connective tissue alteration in the ultimate survival of RGC in chronic experimental glaucoma (former Aim 4, now Aim 3), including the effect of chemical scleral cross-linking. To complete the project in 2 years, we eliminated from the 5 year proposal Hypotheses 7, 8, 9, and 11.

为了将该项目缩短为2年的提案，我保留了总体主题，即研究巩膜和视乳头周围神经乳头的结缔组织对轴突损伤和RGC死亡的影响。取消的5年计划部分是以前的目标2和3，涉及研究神经头毛细血管功能，以及内皮素和肿瘤坏死因子在RGC损伤中的作用。我们期望测试结缔组织改变在慢性实验性青光眼中RGC最终存活中的作用（以前的目标4，现在的目标3），包括化学巩膜交联的作用。为了在2年内完成项目，我们从5年提案中删除了假设7、8、9和11。