Mouse Model Core

鼠标模型核心

• 批准号: 7757167
• 负责人: LARS ECKMANN
• 金额: $ 15.55万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7757167
• 关键词: Animal Model; Animal Technicians; Animals; Biological; Blood; Bone Marrow Transplantation; Breeding; Colitis; Core Facility; Engineering; Environment; Experimental Designs; Goals; Human; Immune system; Individual; Infection; Intestines; Maintenance; Modeling; Mus; Mutant Strains Mice; Preparation; Procedures; Protocol Compliance; Reagent; Research; Research Personnel; Sampling; Scheme; Services; Study models; Tissue Banks; Training; Training Support; cost; cost effective; design; enteric pathogen; experience; experimental analysis; irradiation; mouse model; programs; research study

instmctions): The Mouse Model Core (Core A) is an established Core facility of the Program Project that has the overall goal to enhance the research endeavors of the Units and facilitate the conduct of research by individual Research Units that require support for conducting experiments involving mice, and in mouse breeding and maintenance. The Core offers the following high-quality services in a cost-effective manner to Program investigators: 1. Breeding and maintenance of normal and mutant mice a. Acquisition and basic maintenance of normal and mutant mouse strains b. Design and implementation of breeding schemes involving normal and mutant mice c. Assistance in generating new mutant mice 2. Assistance in conducting mouse experiments a. Infections with enteric pathogens b. Induction and analysis of experimental colitis models c. Irradiation and bone marrow transplantation d. Collection of tissues, blood and fecal samples e. Preparation and use of ligated intestinal loops 3. Administrative and training support for mouse studies a. Administrative assistance in acquiring and transferring animals b. Support in preparation and submission of animal protocols, and compliance procedures c. Training in conducting animal studies The Mouse Model Core is fully equipped and has an experienced animal technician to provide the offered services at the highest quality in a cost-effective manner. The Core interacts closely with individual Program investigators and the other Cores to assist in achieving the scientific objectives of the Program. RELEVANCE (See instmctions): Animal models are critical for immunological research because the complexity of the immune system can only be adequately investigated in the normal biological context. Mice are the preferred model for the studies, since they are genetically closely related to humans, are readily amenable to different experimental designs, and many genetically engineered strains and immunological reagents are commonly available.

指令）： 小鼠模型核心（核心 A）是该计划项目的既定核心设施，具有整体 目标是加强各单位的研究工作并促进个人进行研究 需要支持进行小鼠实验以及小鼠育种和饲养的研究单位 维护。核心以具有成本效益的方式为计划提供以下高质量服务 调查人员： 1. 正常小鼠和突变小鼠的饲养和维护 一个。正常和突变小鼠品系的获得和基本维护 b.正常小鼠和突变小鼠的育种方案的设计和实施 c.协助产生新的突变小鼠 2. 协助进行小鼠实验 一个。肠道病原体感染 b.实验性结肠炎模型的诱导与分析 c.放射治疗和骨髓移植 d.收集组织、血液和粪便样本 e.结扎肠袢的制备及应用 3. 小鼠研究的行政和培训支持 一个。获取和转移动物的行政协助 b.支持准备和提交动物方案和合规程序 c.进行动物研究的培训 小鼠模型核心设备齐全，并有经验丰富的动物技术人员提供所提供的 以具有成本效益的方式提供最高质量的服务。核心与各个程序密切交互 研究人员和其他核心协助实现该计划的科学目标。 相关性（参见说明）： 动物模型对于免疫学研究至关重要，因为免疫系统的复杂性可以 只有在正常的生物学背景下才能充分研究。小鼠是首选模型 由于研究与人类基因密切相关，因此很容易适用于不同的实验 设计，并且许多基因工程菌株和免疫试剂都是常见的。