MARKERS FOR DAT: CONTROL, VARIABILITY AND PERSONALITY

DAT 的标记：控制、可变性和个性

• 批准号: 7578740
• 负责人: David A Balota
• 金额: $ 16.25万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-15 至 2013-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7578740
• 关键词: Alzheimer' s Disease; Area; Attention; Behavioral; Behavioral Assay; Biological Markers; Characteristics; Cognitive; Data; Disease; Dissociation; Elderly; Exclusion; Familiarity; Future; Genetic; Goals; Hour; Individual; Individual Differences; Lead; Measures; Medial; Medicine; Memory; Neurotic Disorders; Onset of illness; Participant; Performance; Personality; Personality Traits; Predisposition; Principal Investigator; Procedures; Process; Reaction Time; Research; Response Latencies; Retrieval; Risk; Role; Semantics; Senile dementia; Staging; Stroke; System; Techniques; Testing; Training Technics; base; cognitive change; executive function; healthy aging; novel; programs; prospective; prospective memory

There is accumulating evidence that early stage Alzheimer's disease reflects a breakdown in attentional control systems that likely contribute to the changes in memory performance, along with other aspects of cognitive performance. Recent evidence indicates that tasks that place a maximum load on attentional systems are particularly useful in serving as a behavioral biomarker both in discriminating healthy aging from early stage DAT, and are correlated with other biomarkers in non-demented older adults. The proposed research plan will continue to longitudinally follow a set of healthy older adults and individuals in the early stages of the disease process, along with individuals who are at risk due to stroke, to better isolate the contributions of novel attentional control measures, and to investigate the extent to which these individuals respond to memory/attention training techniques. We will have three waves of testing, which will be separated by approximately 1.5 years. Each participant will be tested in a single session for each wave of testing, lasting approximately 2 hours. During each wave, we will continue to administer a small battery (no more than 40 minutes) of executive measures (computation span, Stroop, a retroactive interference exclusion measure, and a short switching task). This will afford the ability to continue to follow these individuals with the same set of measures for which we already have data. In addition to the executive control measures, we will also use experimental procedures to provide estimates of three different targeted components in each wave. These will include measures of (a) controlled and automatic processing via the processing dissociation procedure, (b) components of prospective memory performance, and (c) standard mnemonic manipulations (i.e., repeated testing, expanded retrieval, semantic encoding). We will continue to explore distinct measures of participant variability and the components of reaction time distributions that lead to any change in the observed variability estimates as a potential marker for cognitive changes in healthy aging and early stage DAT. In addition, because of recent evidence that certain personality traits (e.g., conscientiousness and neuroticism) predispose individuals for developing DAT, we will explore the modulatory role of personality characteristics in the cognitive markers, and susceptibility to mnemonic techniques. Moreover, we have recently found that personality characteristics are related to cognitive performance including variability estimates. Finally, the behavioral assays obtained in Project 3 will be correlated with the results from the biomarkers available from other projects and cores (e.g., CSF, PIB, genetics, and volumetric measures of targeted areas) to determine which composite measures afford the best behavioral biomarkers.

越来越多的证据表明，早期阿尔茨海默病反映了注意力的崩溃 控制系统，可能有助于存储器性能的变化，沿着的其他方面， 认知绩效最近的证据表明，对注意力施加最大负荷的任务， 系统在作为行为生物标志物方面特别有用， 早期DAT，并与非痴呆老年人的其他生物标志物相关。拟议 研究计划将继续纵向跟踪一组健康的老年人和个人在早期 疾病过程的各个阶段，沿着有中风风险的个体，以更好地隔离 新的注意力控制措施的贡献，并调查在何种程度上，这些人 记忆力/注意力训练技术。我们将有三波测试，这将是 间隔约1.5年。每个参与者将在一个单一的会议测试的每一波 测试，持续约2小时。在每一波，我们将继续管理一个小电池（不 超过40分钟）的执行措施（计算跨度，Stroop，追溯性干扰 排除措施和短切换任务）。这将提供继续遵循这些 使用我们已有数据的同一组指标的个体。除了执行官 控制措施，我们还将使用实验程序，以提供三个不同的目标估计 每一波的成分。这些措施将包括：（a）通过 加工分离程序，（B）前瞻记忆表现的组成部分，和（c）标准 记忆操纵（即，重复测试、扩展检索、语义编码）。 我们将继续探索参与者可变性和反应成分的不同测量方法 导致观察到的变异性估计值发生任何变化的时间分布，作为 健康老龄化和早期DAT的认知变化。此外，由于最近的证据表明，某些 个性特征（例如，神经质和神经质）使个体易于发展DAT，我们 将探讨人格特征在认知标记中的调节作用，以及对 记忆技巧此外，我们最近发现，人格特征与 认知表现，包括变异性估计。最后，在项目3中获得的行为测定将 与来自可从其他项目和岩心获得的生物标志物的结果相关（例如，CSF，PIB， 遗传学和目标地区的体积测量），以确定哪些综合措施提供了 最好的行为生物标志物