Clinical Research in Eating Disorders and Obesity

描述(申请人提供)：饮食失调和肥胖对公众健康的意义是有充分记录的，但已知这些问题对治疗具有抵抗力。本申请是对NIMH以患者为中心的研究(K24)职业中期研究员奖的竞争性续签申请，以解除Wilfley博士的临床、行政和教学职责，以确保有保护的时间：1)继续开发和改进有效的饮食和体重障碍治疗方法，这些治疗方法得到基础行为和生物医学的进步；2)应用科学实施方法，在社区部署基于证据的饮食和体重障碍治疗；3)专注于饮食和体重障碍的预防和早期干预，以防止共病、复发和残疾；以及4)参与教学和培训活动，帮助培养饮食失调和肥胖领域的下一代临床研究人员。在目前的获奖期内，Wilfley博士已经成功地完成了三个由NIH资助的R01，启动了两个由NIH赞助的奖项，还有两个NIH临床研究试验正在进行中。她的研究确定了有效的干预措施，用于患有进食障碍的高危女性、暴饮暴食障碍的治疗和儿童肥胖症。此外，在此期间，她发表了超过45篇同行评议的手稿，并指导了17名博士后和博士后学生以及初级教师。选定的正在进行和正在进行的奖项包括旨在测试对患有神经性厌食症的青少年进行早期干预的研究，为患有进食障碍的高风险女性提供的强化预防方法，以及长期保持儿童体重减轻的方法。这份申请描述了Wilfley博士的职业发展目标，以增强她在转化研究领域的专业知识，特别是弥合从治疗设计和改进到社区治疗的实施和部署之间的差距。她计划加强对神经成像和精神病学遗传学的理解，以促进诊断、预防和治疗与饮食和体重相关的疾病的新策略的开发，并增加她的指导资源。相关性(见说明)：鉴于与饮食失调和肥胖相关的高发病率和死亡率，需要继续改进治疗方法，并将重点放在早期干预和预防上。当务之急是确保将有效的治疗传播到社区并惠及预期治疗的患者。

DESCRIPTION (provided by applicant): The public health significance of eating disorders and obesity are well-documented, yet these problems are known to be resistant to treatment. This application is a request for a competitive renewal of an NIMH Midcareer Investigator Award in Patient Oriented Research (K24) in order to relieve Dr. Wilfley from clinical, administrative, and teaching duties, to ensure protected time to: 1) Continue developing and improving efficacious treatments for eating and weight disorders that are informed by advancements in the basic behavioral and biomedical sciences; 2) Apply scientific implementation methodology to the deployment of evidence-based treatments for eating and weight disorders into the community; 3) Focus on the prevention and early intervention of eating and weight disorders to prevent comorbidity, relapse, and disability; and 4) Engage in teaching and training activities that will help produce the next generation of clinical researchers in the area of eating disorders and obesity. During the present award period, Dr. Wilfley has successfully concluded three NIH-funded R01s, launched two NIH-sponsored awards, and has two more NIH clinical research trials pending. Her studies have identified effective interventions for a subset of women at high risk for developing eating disorders, for the treatment of binge eating disorder, and for childhood obesity. Also, during this time, she has published over 45 peer-reviewed manuscripts, and mentored 17 pre- and post- doctoral students, and junior faculty. Selected ongoing and pending awards include studies designed to test early interventions for adolescents with anorexia nervosa, an enhanced prevention approach for women at very high risk for developing eating disorders, and methods for maintaining weight loss in children over the long-term. This application describes career development goals for Dr. Wilfley to enhance her expertise in the areas of translational research, specifically to bridge the gap from treatment design and refinement to the implementation and deployment of treatments in the community. She plans to enhance her understanding of neuroimaging and psychiatric genetics to facilitate the development of novel strategies for diagnosis, prevention, and treatment of eating and weight related disorders and to augment her mentoring resources. RELEVANCE (See instructions): Given the high morbidity and mortality associated with eating disorders and obesity, a continued refinement of treatment approaches and focus on early intervention and prevention is required. Ensuring that effective treatments are disseminated to the community and reach the patients for whom they are intended is imperative.