Clinical Research in Eating Disorders and Obesity

描述（由申请人提供）：进食障碍和肥胖症的公共卫生意义已得到充分证明，但已知这些问题对治疗具有抗药性。本申请是对NIMH职业中期研究者奖在以患者为导向的研究（K24）的竞争性更新的请求，以减轻Wilfley博士的临床，行政和教学职责，以确保保护时间：1）继续开发和改善饮食和体重障碍的有效治疗方法，这些治疗方法是由基础行为和生物医学科学的进步所告知的; 2）运用科学的实施方法，将饮食和体重障碍的循证治疗部署到社区; 3）注重饮食和体重障碍的预防和早期干预，防止合并症、复发和残疾;以及4）参与教学和培训活动，这将有助于培养下一代饮食失调和肥胖领域的临床研究人员。在本奖项期间，Wilfley博士成功完成了三项NIH资助的R 01，启动了两项NIH赞助的奖项，并有两项NIH临床研究试验正在进行中。她的研究已经确定了有效的干预措施，为一个子集的妇女在高风险发展饮食失调，治疗暴食症，并为儿童肥胖。此外，在此期间，她发表了超过45篇同行评审的手稿，并指导了17名博士生和博士后学生以及初级教师。选定的正在进行和即将颁发的奖项包括旨在测试对患有神经性厌食症的青少年的早期干预措施的研究，对患有饮食失调症的高危妇女的强化预防方法，以及长期保持儿童体重减轻的方法。该应用程序描述了Wilfley博士的职业发展目标，以增强她在转化研究领域的专业知识，特别是弥合从治疗设计和改进到社区治疗实施和部署的差距。她计划提高她的神经影像学和精神遗传学的理解，以促进诊断，预防和治疗饮食和体重相关疾病的新策略的发展，并增加她的指导资源。相关性（参见说明）：鉴于与饮食失调和肥胖症有关的高发病率和死亡率，需要继续改进治疗方法，并注重早期干预和预防。必须确保向社区传播有效的治疗方法，并将其送达患者手中。

DESCRIPTION (provided by applicant): The public health significance of eating disorders and obesity are well-documented, yet these problems are known to be resistant to treatment. This application is a request for a competitive renewal of an NIMH Midcareer Investigator Award in Patient Oriented Research (K24) in order to relieve Dr. Wilfley from clinical, administrative, and teaching duties, to ensure protected time to: 1) Continue developing and improving efficacious treatments for eating and weight disorders that are informed by advancements in the basic behavioral and biomedical sciences; 2) Apply scientific implementation methodology to the deployment of evidence-based treatments for eating and weight disorders into the community; 3) Focus on the prevention and early intervention of eating and weight disorders to prevent comorbidity, relapse, and disability; and 4) Engage in teaching and training activities that will help produce the next generation of clinical researchers in the area of eating disorders and obesity. During the present award period, Dr. Wilfley has successfully concluded three NIH-funded R01s, launched two NIH-sponsored awards, and has two more NIH clinical research trials pending. Her studies have identified effective interventions for a subset of women at high risk for developing eating disorders, for the treatment of binge eating disorder, and for childhood obesity. Also, during this time, she has published over 45 peer-reviewed manuscripts, and mentored 17 pre- and post- doctoral students, and junior faculty. Selected ongoing and pending awards include studies designed to test early interventions for adolescents with anorexia nervosa, an enhanced prevention approach for women at very high risk for developing eating disorders, and methods for maintaining weight loss in children over the long-term. This application describes career development goals for Dr. Wilfley to enhance her expertise in the areas of translational research, specifically to bridge the gap from treatment design and refinement to the implementation and deployment of treatments in the community. She plans to enhance her understanding of neuroimaging and psychiatric genetics to facilitate the development of novel strategies for diagnosis, prevention, and treatment of eating and weight related disorders and to augment her mentoring resources. RELEVANCE (See instructions): Given the high morbidity and mortality associated with eating disorders and obesity, a continued refinement of treatment approaches and focus on early intervention and prevention is required. Ensuring that effective treatments are disseminated to the community and reach the patients for whom they are intended is imperative.