2010 Glycolipid & Sphingolipid Biology Gordon Research Conference

2010糖脂

• 批准号: 7800051
• 负责人: Lina M OBEID
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2010-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7800051
• 关键词: 1,2-diacylglycerol; Achievement; Advanced Development; Aging; Anaplastic astrocytoma; Angiogenesis Inducing Agents; Angioplasty; Antibodies; Apoptosis; Apoptosis Promoter; Apoptotic; Area; Arts; Attention; Bibliography; Biochemical; Biochemistry; Bioinformatics; Biological; Biological Process; Biology; Catheters; Cell Communication; Cell Differentiation process; Cell Membrane Structures; Cell physiology; Cell surface; Cells; Cellular biology; Ceramides; Cerebrosides; Clinical Trials; Colon Carcinoma; Communicable Diseases; Communities; Complex; Country; Detergents; Development; Developmental Biology; Diabetes Mellitus; Diglycerides; Discipline; Disease; Distal; Environment; Enzymes; Etiology; Event; Feedback; Fenretinide; Figs - dietary; Fostering; Functional disorder; Funding; Future; Galactosylceramides; Gangliosides; Generations; Genetic; Glycolipids; Goals; Growth; Growth Factor; Health; Hemostatic function; Human; Hyperplasia; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Inflammatory Response; Information Dissemination; Ionizing radiation; Journals; Lead; Learning; Link; Lipids; Malignant - descriptor; Malignant Neoplasms; Mass Spectrum Analysis; Mediating; Mediator of activation protein; Membrane; Membrane Lipids; Membrane Microdomains; Membrane Structure and Function; Metabolic; Metabolic Pathway; Metabolism; Methods; Minority; Modeling; Molecular; Mus; Myelin; Nature; Neoplasm Metastasis; Ovarian Tissue; Participant; Pathogenesis; Pathology; Pathway interactions; Patients; Peripheral Nervous System Diseases; Pharmacology; Physicians; Platelet-Derived Growth Factor; Play; Proteins; Publications; Radiation; Radiation therapy; Ranvier' s Nodes; Regulation; Regulatory Pathway; Relative (related person); Renaissance; Research; Research Personnel; Resistance; Role; Safingol; Scheme; Science; Scientist; Series; Severities; Signal Pathway; Signal Transduction; Sphingolipids; Sphingomyelinase; Sphingosine; Stimulus; Structure; Sulfoglycosphingolipids; Techniques; Therapeutic; Therapeutic Agents; Toxin; Translational Research; Tumor Necrosis Factor-alpha; Tumor Promoters; Tumor Suppressor Proteins; Tumorigenicity; Ursidae Family; Woman; Work; acid sphingomyelinase; analog; angiogenesis; base; cancer cell; cancer chemoprevention; cancer therapy; cell growth; chemotherapeutic agent; chemotherapy; enzyme pathway; field study; insight; lectures; lipid metabolism; metaplastic cell transformation; next generation; novel; ovarian neoplasm; polarized cell; posters; prognostic; programs; public health relevance; receptor; receptor function; response; restenosis; sphingosine 1-phosphate; sphingosine kinase; symposium; tissue culture; trafficking; tumor; tumor progression

DESCRIPTION (provided by applicant): Partial support is requested for the Gordon Research Conference on Glycolipid and Sphingolipid Biology, to be held at the Ventura Beach Marriott, Ventura, CA from February 7 - 12, 2010 (and approximately this same date in 2012). The purpose of the conference is to encourage the transfer of ideas and information within the community of scientists who work at the cutting edge of glycolipid and sphingolipid research as well as to provide an environment where investigators from other scientific disciplines can learn about, and contribute to, this rapidly evolving field. Sphingolipids participate in many biological processes, including cell growth, differentiation and apoptosis, but only in the past decade have the molecular bases for these functions become clear (i.e., as modulators of membrane structure, cell-cell interactions, receptor functions, and signaling via ceramide, sphingosine 1-phosphate and others potent bioactive lipids). As an understanding of the roles of sphingolipids in disease etiology and treatment--most notably for cancer--has evolved, sphingolipid analogs such as safingol as well as anticancer chemotherapeutics that modify sphingolipid metabolism (such as fenretinide) have entered clinical trials, illustrating the strong partnership of basic and translational research in this field. Important aspects of this Gordon Conference are that it brings together scientists that work in different disciplines, such as basic biochemistry, genetics, developmental biology, cancer chemoprevention and chemotherapy and that it encourages participation of both senior investigators and junior investigators. As with previous Gordon Conferences in this series, there will be a significant percentage of participants from countries outside the U.S. as well as participation by women and minorities. Conferees will be encouraged to participate both in the formal lecture/discussion sessions, and less formally in poster presentations. The platform sessions will cover leading edge research in basic sphingolipid biology and biochemistry, and will include three sessions devoted to translational aspects of sphingolipid biology, specifically, sphingolipids in cancer, in infectious diseases and their roles as toxin receptors. The program will close with a future-oriented session on sphingolipidomics, focusing on the integration of sphingolipid metabolism and signaling, with a view to providing a comprehensive model of the functions of specific sphingolipids in regulating defined aspects of cell biology and and pathobiology.

描述（由申请人提供）：部分支持是为戈登研究会议糖脂和鞘脂生物学，将举行的文图拉海滩万豪酒店，文图拉，加利福尼亚州从2010年2月7日至12日（大约在2012年同一天）。会议的目的是鼓励在糖脂和鞘脂研究前沿工作的科学家社区内转移思想和信息，并提供一个环境，让来自其他科学学科的研究人员可以了解并为这个快速发展的领域做出贡献。鞘脂参与许多生物学过程，包括细胞生长、分化和凋亡，但仅在过去十年中，这些功能的分子基础才变得清楚（即，作为膜结构、细胞-细胞相互作用、受体功能和经由神经酰胺、鞘氨醇1-磷酸和其它有效的生物活性脂质的信号传导的调节剂）。随着对鞘脂在疾病病因学和治疗（尤其是癌症）中的作用的理解不断发展，鞘脂类似物如safingol以及改变鞘脂代谢的抗癌化疗药物（如芬维A胺）已进入临床试验，说明了该领域基础和转化研究的强大伙伴关系。这次戈登会议的重要方面是，它汇集了在不同学科工作的科学家，如基础生物化学，遗传学，发育生物学，癌症化学预防和化疗，它鼓励高级研究人员和初级研究人员的参与。与本系列的前几届戈登会议一样，将有相当比例的与会者来自美国以外的国家，以及妇女和少数民族的参与。鼓励与会者参加正式的讲座/讨论会，以及不太正式的海报展示。平台会议将涵盖基础鞘脂生物学和生物化学的前沿研究，并将包括三个专门讨论鞘脂生物学转化方面的会议，特别是鞘脂在癌症中的作用，传染病及其作为毒素受体的作用。该计划将以一场面向未来的鞘脂组学会议结束，重点关注鞘脂代谢和信号传导的整合，以期提供特定鞘脂在调节细胞生物学和病理学的特定方面的功能的全面模型。