SC COBRE IN LIPIDOMICS AND PATHOBIOLOGY: ADMIN CORE

SC COBRE 在脂质组学和病理学中的应用：管理核心

• 批准号: 8360377
• 负责人: Lina M OBEID
• 金额: $ 22.01万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-07-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360377
• 关键词: Aging; Area; Biology of Aging; Biomedical Research; Cancer Biology; Cell physiology; Centers of Research Excellence; Communicable Diseases; Development; Functional disorder; Funding; Future; Goals; Grant; Growth; Growth and Development function; Inflammation; Mentors; Metabolism; National Center for Research Resources; Neoplasm Metastasis; Pathogenesis; Pathway interactions; Principal Investigator; Process; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resources; Source; Structure; United States National Institutes of Health; base; cost; novel; programs; tumor progression

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The MUSC is an emerging center of excellence in biomedical research with a few key areas of exceptional strength upon which it can build future growth and development. One of these areas is based on the study of bioactive lipids, their structure, metabolism, and function. The scope of this field of research and its development at MUSC allow a transition to global studies on bioactive lipids (designated herein as Lipidomics) and their contribution to mammalian pathophysiology. Thus, the organizing hypothesis of this COBRE states that the diversity of bioactive lipids provides a rich network of pathways that regulate cell function. Perturbations of these pathways contribute to important pathobiologic processes such as cancer progression, metastasis, aging, and fungal pathogenesis. The specific goal of this proposal is to develop an interactive Center of Lipidomics and Pathobiology that will promote the growth and excellence of research at MUSC. This will be achieved by pursuing the following specific aims (1) Mentor an initial group of five targeted junior investigators to develop independent NIH-funded research; (2) Develop novel and critical scientific cores; (3) Recruit additional independent investigators with key expertise; (4) Sustain the growth of the COBRE through the development of specific program projects. These activities should result in a highly developed Center with a critical mass of biomedical excellence in an evolving area of research highly significant to cancer biology, aging, inflammation, and infectious diseases.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 描述（由申请人提供）：MUSC 是一个新兴的生物医学研究卓越中心，在几个关键领域具有非凡的实力，可以在此基础上建立未来的增长和发展。这些领域之一是基于生物活性脂质及其结构、代谢和功能的研究。该研究领域的范围及其在 MUSC 的发展允许过渡到生物活性脂质（本文称为脂质组学）及其对哺乳动物病理生理学的贡献的全球研究。因此，该 COBRE 的组织假设指出，生物活性脂质的多样性提供了调节细胞功能的丰富途径网络。这些途径的扰动有助于重要的病理生物学过程，例如癌症进展、转移、衰老和真菌发病机制。该提案的具体目标是建立一个互动的脂质组学和病理生物学中心，以促进 MUSC 研究的发展和卓越。这将通过追求以下具体目标来实现：(1) 指导由五名初级研究人员组成的初始小组开展由 NIH 资助的独立研究； （2）开发新颖、关键的科学核心； (3) 招募更多具有关键专业知识的独立调查员； (4) 通过制定具体计划项目来维持 COBRE 的发展。这些活动应该会导致一个高度发达的中心，在一个对癌症生物学、衰老、炎症和传染病非常重要的不断发展的研究领域中拥有大量的生物医学卓越人才。