SC COBRE IN LIPIDOMICS AND PATHOBIOLOGY: ADMIN CORE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 描述(由申请者提供)：MUSC是一个新兴的生物医学研究卓越中心，拥有几个具有非凡实力的关键领域，可以在这些领域建立未来的增长和发展。其中一个领域是基于对生物活性脂类及其结构、代谢和功能的研究。这一领域的研究范围及其在MUSC的发展使得对生物活性脂类(在此指定为脂组学)及其对哺乳动物病理生理学的贡献的全球研究得以过渡。因此，科布雷的组织假说表明，生物活性脂类的多样性提供了一个丰富的调节细胞功能的途径网络。这些通路的干扰有助于重要的病理生物学过程，如癌症进展、转移、衰老和真菌发病。这项提议的具体目标是建立一个脂质组学和病理生物学的互动中心，以促进MUSC研究的发展和卓越。这将通过实现以下具体目标来实现：(1)指导首批由五名目标初级调查人员组成的小组，以开发由NIH资助的独立研究；(2)开发新的关键科学核心；(3)招募更多具有关键专业知识的独立调查人员；(4)通过开发具体的计划项目来维持COBRE的增长。这些活动应该会导致一个高度发达的中心，在一个对癌症生物学、衰老、炎症和传染病具有重要意义的不断发展的研究领域，拥有大量的生物医学精英。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): The MUSC is an emerging center of excellence in biomedical research with a few key areas of exceptional strength upon which it can build future growth and development. One of these areas is based on the study of bioactive lipids, their structure, metabolism, and function. The scope of this field of research and its development at MUSC allow a transition to global studies on bioactive lipids (designated herein as Lipidomics) and their contribution to mammalian pathophysiology. Thus, the organizing hypothesis of this COBRE states that the diversity of bioactive lipids provides a rich network of pathways that regulate cell function. Perturbations of these pathways contribute to important pathobiologic processes such as cancer progression, metastasis, aging, and fungal pathogenesis. The specific goal of this proposal is to develop an interactive Center of Lipidomics and Pathobiology that will promote the growth and excellence of research at MUSC. This will be achieved by pursuing the following specific aims (1) Mentor an initial group of five targeted junior investigators to develop independent NIH-funded research; (2) Develop novel and critical scientific cores; (3) Recruit additional independent investigators with key expertise; (4) Sustain the growth of the COBRE through the development of specific program projects. These activities should result in a highly developed Center with a critical mass of biomedical excellence in an evolving area of research highly significant to cancer biology, aging, inflammation, and infectious diseases.