Anxiety Genetics: Progress and New Directions

焦虑遗传学：进展和新方向

• 批准号: 7750042
• 负责人: Steven P. Hamilton
• 金额: $ 4.56万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7750042
• 关键词: Address; Advocate; Age of Onset; Age-Years; Animal Model; Anxiety; Anxiety Disorders; Candidate Disease Gene; Complex; Country; Crohn' s disease; DSM-IV; Data Set; Disease; Educational workshop; Exhibits; Family; Female; Foundations; Generalized Anxiety Disorder; Genes; Genetic; Genetic Variation; Genomics; Grant; Human; Incidence; Individual; Knowledge; Non-Insulin-Dependent Diabetes Mellitus; Obsessive-Compulsive Disorder; Panic Disorder; Post-Traumatic Stress Disorders; Predisposition; Prevalence; Reporting; Research; Research Personnel; Sampling; Source; Specific Phobia; Surveys; Twin Studies; United States National Institutes of Health; Work; case control; data sharing; design; experience; genetic linkage analysis; genetic pedigree; genetic variant; interest; meetings; public health relevance; social; success; symposium; volunteer

DESCRIPTION (provided by applicant): Anxiety disorders are the most common psychiatric conditions, have a moderate genetic component, and have lent themselves to excellent animal models. Modest progress has been made in understanding the genetic influence at the genomic level. We are proposing a conference grant to provide an opportunity for anxiety disorder genetics investigators to survey the current status of the field and to develop collaborative efforts for genetic studies. The disorders of interest include panic disorder, specific phobia, social anxiety disorder, generalized anxiety disorder, and post-traumatic stress disorder. Obsessive compulsive disorder is not included here as there is an existing conference mechanism focused solely on that disorder. The lifetime incidence of DSM-IV anxiety disorders is estimated to be 28.8%, with an average age of onset of eleven years of age. Lifetime prevalence for the disorders mentioned above range from 4.7% to 12.5%, with all being more common in females. Research has shown that anxiety disorders consistently exhibit aggregation in families, and that the source of this aggregation is likely due to genetic factors, with twin studies suggesting a strong contribution from genes. Genetic studies, both linkage analyses in pedigrees and candidate gene studies in case-control samples now provide some evidence that specific chromosomal regions or genes might contribute to the susceptibility to anxiety disorders. Experience with other complex disorders now demonstrate that the samples of individual investigators may be insufficient for discovering anxiety-related genetic variation, and it is clear collaborative studies that combine many samples will have higher chance of success. Similarly, large samples will need to be coordinated for the field to validate reported findings in the extant samples. The R13 mechanism will be used to address the issues of assembling collaborative datasets and sharing data among diverse investigators. The proposed meeting will also serve to summarize current knowledge, and provide plenary talks from leading human geneticists outside of anxiety disorder genetics. At least 25 researchers from nine countries on five continents have expressed interest in participating, with most also volunteering to give presentations, facilitate workshops, and serve on the Steering Committee. A substantial portion of the meeting will be focused on workshops designed to identify potential collaborative projects, and to address the challenges and opportunities they provide.

描述（由申请人提供）：焦虑症是最常见的精神疾病，具有中等的遗传成分，并且适合优秀的动物模型。在了解基因组水平的遗传影响方面已经取得了一定的进展。我们提议提供一项会议拨款，为​​焦虑症遗传学研究人员提供调查该领域现状并开展遗传学研究合作的机会。感兴趣的疾病包括恐慌症、特定恐惧症、社交焦虑症、广泛性焦虑症和创伤后应激障碍。这里不包括强迫症，因为现有的会议机制只关注该疾病。 DSM-IV 焦虑症的终生发病率估计为 28.8%，平均发病年龄为 11 岁。上述疾病的终生患病率为 4.7% 至 12.5%，且所有疾病在女性中更为常见。研究表明，焦虑症在家庭中始终表现出聚集性，这种聚集的根源可能是遗传因素，双胞胎研究表明基因的重要贡献。遗传研究、家系连锁分析和病例对照样本候选基因研究现在提供了一些证据，表明特定的染色体区域或基因可能导致焦虑症的易感性。其他复杂疾病的经验现在表明，个体研究人员的样本可能不足以发现与焦虑相关的遗传变异，而且很明显，结合许多样本的合作研究将有更高的成功机会。同样，需要协调现场的大样本，以验证现有样本中报告的发现。 R13机制将用于解决组装协作数据集和在不同研究人员之间共享数据的问题。拟议的会议还将总结当前的知识，并提供焦虑症遗传学以外的领先人类遗传学家的全体演讲。至少有来自五大洲 9 个国家的 25 名研究人员表示有兴趣参与，其中大多数人还自愿发表演讲、主持研讨会并在指导委员会任职。会议的大部分内容将集中于研讨会，旨在确定潜在的合作项目，并应对它们提供的挑战和机遇。