Core 4: Genetics Core

遗传学核心的目的是为研究项目收集的基因组DNA样本提供遗传分析。集中的人类和灵长类动物样本的基因分型将最大限度地提高我们的效率，利用一致的方法进行和解释基因分型数据。该核心将 有四个主要目标，即a）从个体项目的外周血或唾液中提取基因组DNA; B）对人类和灵长类动物样品中的5-羟色胺转运蛋白启动子重复多态性5-HTTLRR进行基因分型; c）对人类样品中的5个与5-羟色胺相关的基因的单核苷酸多态性（SNP）和重复多态性进行基因分型;和dj表示在人样品的复制样品中显示遗传关联的基因型DNA变体。核心将与项目、生物统计学和成像核心密切合作，以便有效地共享和分析基因型数据。

The purpose of the GENETICS CORE is to provide for genetic analysis of genomic DNA samples collected by the Research PROJECTS. Centralized genotyping of human and primate samples will maximize our efficiency by utilizing consistent methods for carrying out and interpreting genotyping data. This CORE will have four primary goals, which are to a) extract genomic DNA from peripheral blood or saliva from individual PROJECTS; b) to genotype the serotonin transporter promoter repeat polymorphism 5-HTTLRR in human and primate samples; c) to genotype single nucleotide polymorphisrns (SNPs) and a repeat polymorphism from five serotonin-related genes in human samples; and dj to genotype DNA variants showing genetic association in a replication sample of human samples. The CORE will work closely with the PROJECTS and with the biostatistics and imaging COREs to allow efficient sharing and analysis of genotypic data.