Core 4: Genetics Core

核心 4：遗传学核心

• 批准号: 8269758
• 负责人: Steven P. Hamilton
• 金额: $ 6.44万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8269758
• 关键词: Archives; Biometry; Brain; DNA; Data; Development; Genes; Genetic; Genetic Polymorphism; Genomics; Genotype; Goals; HTR2A gene; Human; Image; Individual; Macaca; Methods; Nucleotides; Phenotype; Play; Primates; Research; Research Personnel; Role; Saliva; Sampling; Serotonin; Single Nucleotide Polymorphism; System; Variant; Work; genetic analysis; genetic association; peripheral blood; promoter; serotonin transporter

The purpose of the GENETICS CORE is to provide for genetic analysis of genomic DNA samples collected by the Research PROJECTS. Centralized genotyping of human and primate samples will maximize our efficiency by utilizing consistent methods for carrying out and interpreting genotyping data. This CORE will have four primary goals, which are to a) extract genomic DNA from peripheral blood or saliva from individual PROJECTS; b) to genotype the serotonin transporter promoter repeat polymorphism 5-HTTLRR in human and primate samples; c) to genotype single nucleotide polymorphisrns (SNPs) and a repeat polymorphism from five serotonin-related genes in human samples; and dj to genotype DNA variants showing genetic association in a replication sample of human samples. The CORE will work closely with the PROJECTS and with the biostatistics and imaging COREs to allow efficient sharing and analysis of genotypic data.

GENETICS CORE 的目的是对研究项目收集的基因组 DNA 样本进行遗传分析。通过利用一致的方法来执行和解释基因分型数据，对人类和灵长类动物样本进行集中基因分型将最大限度地提高我们的效率。这个核心将 有四个主要目标，即 a) 从各个项目的外周血或唾液中提取基因组 DNA； b) 对人类和灵长类动物样本中的血清素转运蛋白启动子重复多态性 5-HTTLRR 进行基因分型； c) 对人类样本中五个血清素相关基因的单核苷酸多态性 (SNP) 和重复多态性进行基因分型；和 dj 对 DNA 变体进行基因分型，显示人类样本复制样本中的遗传关联。 CORE 将与项目以及生物统计学和成像 CORE 密切合作，以实现基因型数据的有效共享和分析。