Core 4: Genetics Core

遗传学核心的目的是为研究项目收集的基因组DNA样本提供遗传分析。通过使用一致的方法来执行和解释基因分型数据，人类和灵长类动物样本的集中基因分型将使我们的效率最大化。这个核心将

The purpose of the GENETICS CORE is to provide for genetic analysis of genomic DNA samples collected by the Research PROJECTS. Centralized genotyping of human and primate samples will maximize our efficiency by utilizing consistent methods for carrying out and interpreting genotyping data. This CORE will have four primary goals, which are to a) extract genomic DNA from peripheral blood or saliva from individual PROJECTS; b) to genotype the serotonin transporter promoter repeat polymorphism 5-HTTLRR in human and primate samples; c) to genotype single nucleotide polymorphisrns (SNPs) and a repeat polymorphism from five serotonin-related genes in human samples; and dj to genotype DNA variants showing genetic association in a replication sample of human samples. The CORE will work closely with the PROJECTS and with the biostatistics and imaging COREs to allow efficient sharing and analysis of genotypic data.