238th American Chemical Society National Meeting

描述(由申请者提供)：本资助申请申请资助一系列以“化学毒理学的新面貌”为题的研讨会。这些研讨会是美国化学学会化学毒理学分会将于2009年8月16日至20日在华盛顿特区举行的第238届全国学会会议和博览会上提出的计划的一部分。这些研讨会将为介绍强调现代科学方法和基于化学毒理学的应用的新研究提供论坛，包括(1)水生毒理学的进展，重点是改善风险评估的联系机制和监测，(2)安全测试中的人类药物代谢物，(3)药物引起的线粒体功能障碍与人类疾病，(4)DNA加合物与人类健康，以及(5)包括铂为基础的化疗的癌症治疗的新方法。毒理学领域的化学研究最近已转向开发新的战略，以更好地了解化学品与复杂的生物和环境系统相互作用的机理方面。在将这一理解应用于人类健康问题方面的进展具有巨大的创新和显著进展的潜力。然而，该领域的广度带来的持续挑战集中在将所有专注于基于化学的解决方案、但沉浸在不同生物医学领域的个人聚集在一起。因此，需要将这次会议作为一个主要的全国场所，将这一不同的化学家群体聚集在一起，一个非常受人尊敬和多样化的科学家群体已经同意展示他们的最新发现。 公共卫生相关性：计划中的研讨会与国家卫生研究院在环境健康、癌症治疗和病因学、药物新陈代谢和毒性以及普通医学领域的目标相关。更广泛的科学界还将发现，所提供的信息与生物、药物和分析化学以及化学毒理学领域有关。将向研究生和博士后研究员颁发旅行奖，以确保下一代科学家了解药物发现、质谱学、合成有机化学和化学致癌等领域的重要进展，以及他们如何共同努力开发确定疾病病因和风险的新方法。

DESCRIPTION (provided by applicant): This grant application requests funding for partial support of a series of symposia with the title "New Facets of Chemical Toxicology." These symposia are part of the program to be presented by the American Chemical Society Division of Chemical Toxicology at the 238th National Meeting and Exposition of the Society in Washington, DC on August 16-20, 2009. These symposia will provide forums for the presentation of new research that emphasizes modern scientific approaches and applications based in chemical toxicology, including (1) Advances in Aquatic Toxicology, with emphasis on linking mechanism and monitoring to improve risk assessment, (2) Human Drug Metabolites in Safety Testing, (3) Drug-Induced Mitochondrial Dysfunction and Human Disease, (4) DNA Adducts and Human Health, and (5) New approaches for Cancer Therapy involving Platinum-based Chemotherapeutics. Chemistry research in the area of toxicology has recently shifted to the development of newer strategies for better understanding mechanistic aspects of interactions of chemicals with complex biological and environmental systems. Progress in applying this understanding to human health concerns has great potential for innovative and dramatic advances. However, a continued challenge imposed by the breadth of the field centers on bringing together individuals who are all focused on chemistry-based solutions, but immersed within diverse biomedical arenas. Thus, this meeting is needed as a premiere national venue to bring this diverse group of chemists together, and a highly respected and diverse group of scientists have agreed to present their newest findings. Public Health Relevance: The planned symposia have relevance to the goals of the National Institutes of Health in the areas of environmental health, cancer therapeutics and etiology, drug metabolism and toxicity, and general medicine. The broader scientific community will also find the information presented relevant in the fields of biological, medicinal and analytical chemistry as well as chemical toxicology. Travel awards will be made to graduate students and postdoctoral fellows to ensure that the next generation of scientists is aware of the important advances in the fields of drug discovery, mass spectrometry, synthetic organic chemistry and chemical carcinogenesis to mention a few and how they work in concert to develop new ways to determine disease etiology and risk.