2009 Barrier Function of Mammalian Skin

描述（由申请人提供）：关于哺乳动物皮肤屏障功能的戈登研究会议（GRC）是两年一次的活动，计划于2009年8月9日至14日在新罕布什尔州的沃特维尔山谷举行第11次连续会议。本次会议是关于哺乳动物屏障的主要国际研究论坛，重点关注表皮中正常和患病屏障形成和功能的生物物理学，生物学和临床方面。这个会议通常是完全超额认购，这使得它可以接受来自学术界，工业界和政府的与会者的最佳组合。这次会议的组成是混合的，初级和高级科学家的代表性相当，约40%的女性与会者，40-50%的与会者来自海外。组织者正在共同努力，从世界各地招募演讲者和与会者参加2009年的会议，特别是从东欧，亚洲和前苏联国家。2009年会议提出了一个平衡的主题，与个别会议和/或选定的演讲致力于：分子调控和基质信号在屏障形成和再生;屏障结构和功能：从红外，氘核磁共振和汽车光谱的见解;膜脂质转运和ABC转运蛋白在板层体形成和皮肤屏障功能;角质层结构、功能和疾病中的蛋白酶调节;皮肤生物物理学和生物力学;皮肤作为心理-感觉屏障器官;其他屏障/其他世界：来自GI、胆汁和肺屏障的教训;屏障功能中的电生理学;经皮渗透和建模：数学与小鼠辩论;皮肤病和修复中有缺陷屏障的临床尺寸;日益恶劣环境中的抗菌屏障。此外，一个热门话题/年轻的调查员会议将包括六至七个从海报主持人选择的演讲。最后，为了补充本次会议的各种主题，安排在晚上举行三场海报会议，每场会议最多有30场演讲。从NIAMS请求资金支持总费用的一部分;其余部分将由戈登研究会议基金会提供的23，500美元赠款支持，额外的款项主要用于支持国外旅行以及与本次会议相关的最低限度的社会活动，正在向行业征求。2009年屏障研讨会将是一个重要的跨学科场所，将介绍和分享这一领域的最新信息和发展。本次会议有望为哺乳动物皮肤屏障的起源，功能，维护和修复提供新的见解，这将有望为皮肤和其他疾病患者带来直接，实际的后果。

DESCRIPTION (provided by applicant): The Gordon Research Conference (GRC) on Barrier Function of Mammalian Skin is a biennial event, scheduled for its eleventh consecutive meeting from August 9-14, 2009 at the Waterville Valley Site in New Hampshire. This conference represents the primary international research forum on the mammalian barrier, and is focused on the biophysical, biological, and clinical aspects of both normal and diseased barrier formation and function in the epidermis. This conference is generally fully- to over-subscribed, which makes it possible to accept an optimal mix of attendees from academics, industry and government. The composition of this conference is well- mixed, with junior and senior scientists being equally represented, with approximately 40% females attendees, and 40-50% of attendees from overseas. The organizers are making a concerted effort to recruit speakers and attendees from around the world for the 2009 meeting, particularly from Eastern Europe, Asia, and Former Soviet Union countries. The 2009 conference proposes a balance of topics, with individual sessions and/or selected presentations devoted to: Molecular regulation and matrix signaling in barrier formation and regeneration; Barrier structure and function: Insights from IR, deuterium NMR, & CARS spectroscopy; Membrane lipid transport and ABC transporter proteins in lamellar body formation and skin barrier function; Protease regulation in stratum corneum structure, function, and disease; Skin biophysics and biomechanics; Skin as a psycho-sensory barrier organ; Other barriers/other worlds: lessons from GI, bile and lung barriers; Electrophysiology in barrier function; Percutaneous penetration and modeling: the Math vs. Mouse debate; Clinical dimensions of defective barriers in skin disease and repair; Anti-microbial barriers in an increasingly-hostile environment. In addition, a Hot Topics/Young Investigators session will include six-to-seven presentations selected from poster presenters. Finally, to complement the diverse themes of this meeting, three poster sessions are scheduled for the evenings, with up to 30 presentations in each session. Funds are requested from NIAMS to support a portion of the total expenses; the remainder will be supported by a $23,500 grant from the Gordon Research Conferences Foundation, with additional sums, primarily to support foreign travel as well as the minimal social activities associated with this conference, being solicited from industry. The 2009 Barrier GRC will be an important interdisciplinary venue, where the latest information and developments in this field will be presented and shared. This conference promises to provide new insights into the origin, function, maintenance, and repair of the mammalian skin barrier that will hopefully lead to immediate, practical consequences for patients with skin and other disorders.