Making Muscle in the Embryo and Adult

在胚胎和成人中形成肌肉

• 批准号: 7673154
• 负责人: Robert S. Krauss
• 金额: $ 2.5万
• 依托单位: SOCIETY FOR MUSCLE BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-08 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7673154
• 关键词: Address; Adult; Aging; Area; Biological Models; Biology; Cell Lineage; Cell Therapy; Cells; Collaborations; Communities; Complex; Data; Development; Developmental Cell Biology; Disease; Embryo; Embryonic Development; Fertilization; Fostering; Genetic; Heterogeneity; Human Genetics; Injury; International; Joints; Knowledge; Life; Light; Malignant Neoplasms; Molecular; Molecular and Cellular Biology; Muscle; Muscle Development; Muscle satellite cell; Mutation; Myoblasts; Myopathy; Natural regeneration; Nature; Neuromuscular Diseases; New York; New York City; Participant; Pattern; Pericytes; Process; Publishing; Regulation; Request for Applications; Research; Research Personnel; Schedule; Signal Transduction; Skeletal Muscle; Societies; Stem cells; Time; Transcriptional Regulation; Translational Research; Universities; Work; abstracting; age related; career; cell growth regulation; cell type; extracellular; frontier; insight; meetings; muscle form; muscle regeneration; myogenesis; nerve supply; novel strategies; posters; prospective; satellite cell; somitogenesis; stem cell biology; stem cell niche; symposium; transcription factor

DESCRIPTION (provided by applicant): Krauss, Robert's "Making Muscle in the Embryo and Adult" application requests partial support to convene an international meeting, "Making Muscle in the Embryo and Adult". This is a joint meeting of the "Frontiers in Myogenesis" and "Skeletal Muscle Satellite and Stem Cells" meetings that are sponsored by the Society for Muscle Biology and FASEB, respectively. These meetings have been held triennially for more than 20 years, and biennially for more than ten years, respectively. Because both meetings were scheduled to occur in Spring/Summer 2009, and the prospective audiences are partially overlapping, the organizers joined forces for a single inclusive meeting. The meeting will be held May 28 - June 2, 2009 on the campus of Columbia University, New York City, and we expect to attract more than 300 participants from around the world. The joint nature of this meeting is significant and timely for several reasons. The fields of embryonic and adult myogenesis, development and regeneration, have been converging for several years with many investigators now working in both areas and much healthy cross-fertilization. While there has always been overlap between the two meetings, this 2009 meeting will bring the two complete communities together for the first time in approximately ten years. The overall objective of this meeting is two- fold: 1) to highlight recent advances in regulatory mechanisms in muscle development, muscle regeneration, and muscle stem cell biology and to emphasize how these advances are informing potential therapies for myopathies; and 2) to bring together experts in developmental, cell and molecular biology, adult muscle biology, human genetics and translational research pertinent to muscle disease so as to stimulate new research and foster collaboration in these fields at both the basic and translational levels. Ten plenary sessions presenting 63 speakers (20 selected from the submitted abstracts), at the senior, mid-career and junior levels, will address: Somitogenesis and myogenesis; Transcriptional regulation of myogenesis; Patterning of muscle; Myoblast differentiation; Developmental origins of satellite cells; Heterogeneity of muscle precursor cells; Muscle stem cell niche and fate; Regulation of adult muscle mass; Muscle stem cells in cancer and aging; and Muscle diseases and therapies. Three evening dedicated poster sessions that comprise these areas will be held. Importantly, the participants of this conference represent interdisciplinary groups that will provide a comprehensive analysis and integration of recent discoveries in the field. Furthermore, the conference will promote cross-fertilization of ideas and collaborative interactions that will help drive study of muscle biology forward in the coming years. We expect that the major advances in muscle development, muscle stem cells and regeneration, and muscle disease that have taken place since the previous "Frontiers in Myogenesis" and "Skeletal Muscle Satellite and Stem Cells" conferences will make this upcoming, joint meeting in New York an essential gathering for investigators across these areas of muscle biology.

描述（由申请人提供）：克劳斯，罗伯特的“在胚胎和成人中制造肌肉”申请要求部分支持召开国际会议，“在胚胎和成人中制造肌肉”。这是由肌肉生物学学会和FASEB分别赞助的“肌生成前沿”和“骨骼肌卫星和干细胞”会议的联合会议。这些会议已分别每三年举行一次和每两年举行一次。由于这两次会议都计划在2009年春夏举行，而且预期的受众部分重叠，组织者联合起来举办了一次包容性会议。会议将于2009年5月28日至6月2日在纽约市的哥伦比亚大学校园举行，预计将吸引来自世界各地的300多名与会者。出于多种原因，这次会议的联合性质是重要而及时的。胚胎和成人肌肉发生、发育和再生的领域已经融合了几年，许多研究人员现在正在这两个领域工作，并且有许多健康的交叉受精。虽然这两次会议之间一直存在重叠，但2009年的会议将在大约十年内首次将两个完整的社区聚集在一起。本次会议的总体目标有两个方面：1）强调肌肉发育、肌肉再生和肌肉干细胞生物学调节机制的最新进展，并强调这些进展如何为肌病的潜在治疗提供信息; 2）汇集发育、细胞和分子生物学、成人肌肉生物学与肌肉疾病有关的人类遗传学和转化研究，以刺激新的研究，并促进这些领域在基础和转化层面的合作。10次全体会议，63位发言人（从提交的摘要中选出20个），在高级，中级和初级水平，将解决：躯体发生和肌发生;肌发生的转录调节;肌肉的模式化;成肌细胞分化;卫星细胞的发育起源;肌肉前体细胞的异质性;肌肉干细胞生态位和命运;成人肌肉质量的调节;癌症和衰老中的肌肉干细胞;肌肉疾病和治疗。三个晚上专门海报会议，包括这些领域将举行。重要的是，本次会议的与会者代表跨学科小组，将提供该领域最新发现的全面分析和整合。此外，会议将促进思想的交叉和协作互动，这将有助于推动肌肉生物学在未来几年的研究。我们预计，在肌肉发育，肌肉干细胞和再生，以及肌肉疾病，已经发生了自以前的“肌生成前沿”和“骨骼肌卫星和干细胞”会议的重大进展将使这个即将到来的，在纽约的联合会议在肌肉生物学的这些领域的研究人员的重要聚会。