2009 Salivary Glands and Exocrine Secretion Gordon Research Conference

描述（由申请人提供）：本提案为将于2009年2月8日至13日在德克萨斯州加尔维斯顿的加尔维斯酒店举行的第七届戈登唾液腺和外分泌研究会议寻求部分支持。这次会议非常重要，因为它是外分泌生物学领域卓越的多学科会议，因此汇集了已有的唾液和外分泌腺研究人员，包括基础和转化人员，以及来自相关领域的有前途的年轻科学家和专家。本次会议的总体目标是提供一个论坛，介绍和讨论前沿研究，旨在了解唾液腺和相关外分泌腺的生理学和病理生理学。第二个目标是促进和加强这些相关领域的研究人员之间的合作。为此，会议将突出与研究唾液腺和其他外分泌腺（包括胰腺、泪腺、肺和乳腺）的研究人员分享的主题问题。该计划将由9个全体会议组成，其中包括2个由国际知名研究人员参加的主题演讲和2个海报会议。主题包括参与外分泌腺发育和再生的分子机制，干细胞，信号转导和基因调控，以及蛋白质和液体分泌。这些过程的失调在组织损伤中所起的作用，以及“外分泌病”如萎缩性脊髓侧索硬化症、干眼症和胰腺炎的发生和发展也将是一个特别的特征。广泛的国内和国际演讲者已经确定，包括有前途的年轻研究者以及更成熟的研究者。组织团队认识到需要鼓励唾液腺和外分泌腺生物学的发展和进步，为此，我们将努力特别鼓励年轻研究者和新研究者参与这一研究领域。

DESCRIPTION (provided by applicant): This proposal seeks partial support for the seventh Gordon Research Conference on Salivary Glands and Exocrine Secretion to be held February 8-13th, 2009 at the Hotel Galvez, Galveston, Texas. This meeting is highly significant as it is the preeminent multi-disciplinary conference in the exocrine biology field, and as such brings together established salivary and exocrine gland investigators, both basic and translational with promising more junior scientists and experts from associated fields. The overall goal of this conference is to provide a forum for presentation and discussion of cutting edge research directed toward understanding the physiology and pathophysiology of the salivary gland and related exocrine glands. A secondary goal is to facilitate and strengthen collaborations between investigators in these related fields. To this end the conference will highlight the topical issues shared with researchers working in salivary and other exocrine glands including pancreas, lacrimal, lung and mammary gland. The program will be comprised of nine plenary sessions, and include two keynote addresses featuring established investigators of international stature, and two poster sessions. Topics to be covered include the molecular mechanisms involved in exocrine gland development and regeneration, stem cells, signal transduction and gene regulation, and protein and fluid secretion. The role dysregulation of these processes play in tissue damage, and the initiation and progression of "exocrineopathies" such as Sjogrens syndrome, dry eye and pancreatitis will also be a particular feature. A broad range of national and international speakers have been identified with the inclusion of promising young investigators as well as more established investigators. The organizing team recognizes the need to encourage the growth and advancement of salivary and exocrine gland biology and to this end we will endeavor to particularly encourage the participation of young investigators and investigators new to this field of research. PUBLIC HEALTH RELEVANCE: This conference is highly health related in that it will promote discussion and prioritization of the important future research directions pertinent to understanding the pathophysiology of exocrine glands and their secretions. A particular feature of this meeting will be a focus on the initiation and progression of human disease that arises from exocrine gland dysfunction, such as Sjogrens syndrome, dry eye and pancreatitis. Tissue damage to the salivary gland resulting from irradiation, and strategies to prevent damage and/or regenerate the gland will also be a focus of the scientific presentations.