2011 Salivary Glands and Exocrine Biology Gordon Research Conference

2011年唾液腺和外分泌生物学戈登研究会议

• 批准号: 8059865
• 负责人: MARY ELAINE REYLAND
• 金额: $ 3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-01-07 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8059865
• 关键词: Achievement; Address; Affect; Area; Artificial Saliva; Biological Models; Biology; Cells; Cholinergic Receptors; Clinical; Collaborations; Deglutition; Dental caries; Development; Diagnostic; Disease; Excision; Exocrine Glands; FGFR2 gene; Faculty; Functional disorder; Gene Transfer; Generations; Genetic; Gland; Glycobiology; Goals; Head and Neck Cancer; Head and Neck Neoplasms; Health; Health Status; Hereditary Disease; Human; Immune System Diseases; Immunology; Individual; Infection; International; Knowledge; LADD syndrome; Lacrimal gland structure; Lead; Learning; Maintenance; Major salivary gland structure; Malignant Neoplasms; Mission; Molecular; Muscarinics; Mutation; Natural regeneration; Online Mendelian Inheritance In Man; Oral cavity; Oral health; Outcome; Pancreas; Pancreatitis; Participant; Patients; Periodontal Diseases; Pharmacologic Substance; Physiology; Play; Quality of life; Radiation; Rare Diseases; Receptor Cell; Research; Research Personnel; Role; Saliva; Salivary; Salivary Gland Diseases; Salivary Glands; Scientist; Signal Transduction; Sjogren' s Syndrome; Stem cells; Syndrome; Systems Biology; Texas; Therapeutic; Tissue Engineering; Tissues; Translational Research; Tumor Biology; Xerostomia; cancer therapy; chronic pain; design; digital; eye dryness; fibroblast growth factor 10; forging; frontier; gene therapy; gland development; graduate student; human disease; improved; induced pluripotent stem cell; insight; irradiation; lacrimal; meetings; novel; oral infection; peer; posters; prevent; progenitor; programs; receptor; regenerative; repaired; saliva diagnostic; saliva secretion; stem; symposium; therapy design; tissue regeneration; tool; tumor

DESCRIPTION (provided by applicant): This proposal seeks partial support for the 8th Gordon Research Conference on Salivary Glands and Exocrine Biology to be held February 6-11th, 2011 at the Hotel Galvez, Galveston, Texas. This meeting is highly significant as it is the preeminent multi-disciplinary conference in the salivary gland and exocrine biology fields, and brings together established investigators, both basic and translational, with promising junior scientists and experts from associated fields. The overall goal of this conference is to bring these investigators together to present their latest unpublished research, and engage in intensive, yet informal, discussions at the frontier of the field in an "off-the-record" fashion. A secondary goal is to facilitate salivary researchers to form collaborations with investigators in complementary fields, including basic, translational and clinical researchers. The first Specific Aim is to promote discussion and prioritization of the important future research directions relevant to understanding the development, physiology, and pathophysiology of salivary glands and other exocrine glands (e.g. lacrimal and pancreas) and their secretions, including state-of-the-art diagnostic and therapeutic advances. A particular feature of the program will be a broadening of focus to include tumor biology, advances in stem/progenitor and iPS cells, salivary diagnostics, glycobiology, and systems biology. A second Specific Aim is to provide a venue for junior Investigators at the Graduate Student, Postdoctoral, and Junior Faculty levels to discuss their current research, and forge scientific interactions including collaborations. This is essential for them to build networks with their peers that may lead to a lifetime of collaboration and scientific achievement, and will stimulate the retention of the most talented junior investigators in the field. The program will be comprised of nine plenary sessions, and include two keynote addresses featuring investigators of international stature, and two poster sessions. The meeting has three major themes, with sessions relating to 1) Molecular mechanisms of development and function, 2) Exocrineopathies, tumors, and genetics of disease, 3) Diagnostics and therapeutics. The long-term goal of this meeting is to incorporate what we learn about development, physiology, and disease, to design treatments for loss of either salivary tissue or glandular function. Saliva plays a critical role in the maintenance of oral health and an irreversible loss of salivary gland function occurs after removal of salivary tumors, after therapeutic radiation of head and neck tumors, as a result of Sjogren's syndrome, and in certain rare genetic syndromes affecting gland development. The loss of salivary function reduces oral health increases oral infections, dental caries, and periodontal disease and significantly decreases quality of life. The outcomes of this conference are directly relevant to NIDCR's mission, "to improve the oral health of the nation". The meeting will improve our understanding of the molecular mechanisms involved in exocrine gland development, physiology, and pathophysiology providing a rationale for repair, regeneration, or reengineering approaches to restore secretory function. PUBLIC HEALTH RELEVANCE (provided by the applicant): This conference is highly health related in that it will promote discussion and prioritization of the important future research directions pertinent to understanding the pathophysiology of exocrine glands and their secretions. There will be a focus on the molecular mechanism underlying human disease that result in exocrine gland dysfunction, such as Sjogrens syndrome, dry eye, and pancreatitis and tissue damage resulting from irradiation, and strategies to prevent damage and/or regenerate the gland. The meeting will also focus on the use of salivary secretions as a diagnostic tool for human diseases such as cancer and auto immune diseases.

描述（由申请人提供）：本提案寻求对将于2011年2月6日至11日在德克萨斯州加尔维斯顿加尔维斯顿酒店举行的第8届戈登唾液腺和外分泌生物学研究会议的部分支持。这次会议是非常重要的，因为它是唾液腺和外分泌生物学领域杰出的多学科会议，并汇集了基础和翻译研究人员，以及来自相关领域的有前途的年轻科学家和专家。本次会议的总体目标是将这些研究人员聚集在一起，介绍他们最新的未发表的研究，并以“非正式”的方式在该领域的前沿进行深入而非正式的讨论。第二个目标是促进唾液研究人员与互补领域的研究人员，包括基础，翻译和临床研究人员形成合作。第一个具体目标是促进讨论和优先考虑与了解唾液腺和其他外分泌腺（例如泪腺和胰腺）及其分泌物的发育，生理学和病理生理学相关的重要未来研究方向，包括最先进的诊断和治疗进展。该计划的一个特点是扩大重点，包括肿瘤生物学，干/祖细胞和iPS细胞的进展，唾液诊断，糖生物学和系统生物学。第二个具体目标是为研究生，博士后和初级教师级别的初级研究人员提供一个场所，以讨论他们目前的研究，并建立包括合作在内的科学互动。这对于他们与同行建立网络至关重要，这可能导致终身合作和科学成就，并将激励留住该领域最有才华的初级研究人员。该计划将包括九个全体会议，包括两个主题演讲，具有国际地位的研究人员，和两个海报会议。会议有三大主题，会议涉及1）发育和功能的分子机制，2）外分泌疾病，肿瘤和疾病遗传学，3）诊断和治疗。这次会议的长期目标是结合我们对发育，生理学和疾病的了解，设计唾液组织或腺体功能丧失的治疗方法。唾液在维持口腔健康中起着关键作用，并且唾液腺功能的不可逆丧失发生在唾液腺肿瘤切除后、头颈部肿瘤的治疗性放射后、干燥综合征的结果以及影响腺体发育的某些罕见遗传综合征中。唾液功能的丧失会降低口腔健康，增加口腔感染、龋齿和牙周病，并显著降低生活质量。这次会议的结果与NIDCR的使命“改善全国口腔健康”直接相关。会议将提高我们对参与外分泌腺发育，生理学和病理生理学的分子机制的理解，为修复，再生或重建方法以恢复分泌功能提供理论基础。 公共卫生相关性（由申请人提供）：本次会议与健康高度相关，因为它将促进与了解外分泌腺及其分泌物的病理生理学相关的重要未来研究方向的讨论和优先顺序。将重点关注导致外分泌腺功能障碍的人类疾病的分子机制，如干燥综合征，干眼，胰腺炎和辐射引起的组织损伤，以及防止损伤和/或再生腺体的策略。会议还将重点讨论唾液分泌物作为癌症和自身免疫性疾病等人类疾病的诊断工具。