Sixth International Uppsala Conference on Electron Capture and Transfer Dissociat

描述（由申请人提供）：今年是电子捕获解离的十周年，从那时起，电子捕获解离及其后代电子转移解离（ETD）已经成为蛋白质序列分析领域的关键参与者。这些方法被证明对从完整蛋白测序（自上而下）到大规模翻译后修饰分析的生物学应用至关重要。在过去的两年中，支持etd的质谱仪已经广泛使用，至少有三个商业应用。我们估计目前全世界至少有150个ETD系统在运行——毫无疑问，其中大多数是用NIH的资金购买的。这些技术与更常见的碰撞激活方法非常不同，对大多数实验室来说都是新的。这些差异跨越了基本原理、方法和信息学方法。在这次会议上，我们寻求促进这些领域信息的发展和传播，以推动蛋白质序列分析领域的发展，将领域领导人聚集在一起参加为期三天的会议。该计划将包括两天半的讲座和海报会议。我们设想时间表将允许25 - 30讲座从世界各地的领域领袖。我们选择了世界著名的Monona Terrace会议中心（由Frank Lloyd Wright设计）作为会场，该中心位于我们州首府麦迪逊的中心。我们预计出席人数约为100人，但计划对整个会议进行免费网络直播。

DESCRIPTION (provided by applicant): This year marks the tenth anniversary of electron capture dissociation - since that time ECD and its offspring, electron transfer dissociation (ETD), have become key players in the field of protein sequence analysis. The methods are proving critical for biological applications ranging from intact protein sequencing (top-down) to large-scale post-translational modification analysis. In the past two years ETD-enabled mass spectrometers have become widely available with no less than three commercial implementations. We estimate at least 150 ETD systems are now operating worldwide - doubtless the majority of these were purchased with NIH funds. The techniques are very different from the more commonplace collision-activated approaches and are new to most laboratories. These differences span fundamentals, methods, and informatic approaches. At this meeting we seek to catalyze the development and spread of information in these areas for advancing the field of protein sequence analysis by bringing together field leaders for a three day conference. The program will consist of two and half days of lectures and poster sessions. We envision the schedule shall permit 25 - 30 lectures drawn from field leaders across the world. We have selected the world-renowned Monona Terrace Conference Center (designed by Frank Lloyd Wright) in the heart of Madison, our states capitol, as the venue. We anticipate an attendance of ~ 100, but plan to webcast the entire conference free of charge. PUBLIC HEALTH RELEVANCE: Relevance Technologies for sensitive protein sequence analysis are vital to further our understanding of human biology. Electron capture and transfer dissociation are two recently developed technologies that have already begun to transform the process of protein sequence analysis, including post-translational modification identification. This meeting with catalyze further development in this area and will make the current state-of-the-art known to the broad community of users.