Portable High Resolution Detector for Rapid Field Arsenic Test in Drinking Water

描述（由申请人提供）：Agiltron提议开发一种便携式高分辨率检测器，用于饮用水中砷的快速现场测试，基于表面增强拉曼光谱（SERS）和纳米结构SERS衬底。在项目的第一阶段，我们将通过基于高结晶银纳米单层的Langmuir-Blodgett单层组装制造SERS衬底，基于现成产品组装便携式拉曼光谱仪设备，以及演示高分辨率和高可靠性的地下水砷检测来证明可行性。在第二阶段，将制作一个功能齐全、符合性能规范的砷检测装置原型。在第二阶段，我们亦会进行实验室测试和实地测试，以展示便携式高分辨率检测仪在饮用水中快速实地检测砷的优点。现有的现场检测砷的方法有比色法、便携式x射线荧光法（XRF）、阳极溶出伏安法（ASV）和激光诱导击穿光谱法（LIBS）等，但它们都有不同的缺点，如灵敏度低、产生有毒的砷气体、受到其他金属材料的干扰、误读率高等。Agiltron在这里提出的解决方案是基于我们在便携式SERS检测设备方面的经验，以及我们的研究合作伙伴加州大学伯克利分校的突破性纳米SERS基板，该基板已经证明了水中砷的检测极限为1 ppb。该项目的最终产品能够对水中的砷进行快速、可靠、高灵敏度和高成本效益的检测。公共健康相关性：砷是一种众所周知的有毒化学物质，被环境保护署（EPA）和世界卫生组织（WHO）列为已知致癌物。世界卫生组织和美国的指导方针建议，饮用水中的砷含量不超过10微克/升（ppb）。该项目开发了一种便携式和经济有效的装置，用于现场砷检测，其灵敏度为1 ppb。该装置灵敏度高，不产生有毒的砷气体，易于操作，无干扰，成本低，优于现有技术。

DESCRIPTION (provided by applicant): Agiltron propose to develop a Portable High Resolution Detector for Rapid Field Arsenic Test in Drinking Water, based on Surface-Enhanced Raman Spectroscopy (SERS) and Nanostructured SERS substrates. In Phase I of the program, we will demonstrate feasibility by fabricating SERS substrates based on Langmuir-Blodgett monolayer assembly of highly crystalline silver nanocrystal monolayer, assembling of a portable Raman spectroscope devices based on off-shelf products, and demonstrating arsenic detection in ground water with high resolution and high reliability. A fully functional Arsenic detection device prototype meeting the performance specifications will be fabricated in Phase II. In Phase II we will also carry out laboratory tests and on-field test to demonstrate the advantages of Portable High Resolution Detector for Rapid Field Arsenic Test in Drinking Water. The current available field assays to measure arsenic include Colorimetric Test Kits, Portable X-ray Fluorescence (XRF), Anodic Stripping Voltammetry (ASV), and Laser Induced Breakdown Spectroscopy (LIBS), etc, however all of them have different disadvantages to be applied for on-field test, such as low sensitivity, generation of toxic arsine gas, interference from other metal materials, high rate of false reading, etc. The solution that Agiltron proposes here is based on our experience of portable SERS detection devices, and the breakthrough nano-enabled SERS substrates from our research partner, UC Berkeley, which have demonstrated a detection limit of 1 ppb for Arsenic in water. The final product of this project enables rapid, reliable, high sensitive and cost effective tests for water arsenic. PUBLIC HEALTH RELEVANCE: Arsenic is a well-known toxic chemical that the Environmental Protection Agency (EPA) and the World Health Organization (WHO) list as a known carcinogen. The World Health Organization and US guidelines recommend the arsenic values in drinking water to be no more than 10 ug/L (ppb). This project develops a portable and cost effective device for in-field arsenic detection with a demonstrated sensitivity of 1 ppb. The device is superior to current technologies for its high sensitivity, no generation of toxic arsine gas, ease of operation, free from interference, and low cost.