Super-resolution dual-energy dental CT based on distributed x-ray source and photon counting detector

基于分布式X射线源和光子计数探测器的超分辨率双能牙科CT

• 批准号: 10258444
• 负责人: Emre Toker
• 金额: $ 22.17万
• 依托单位: TETRAIMAGING, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-21 至 2023-09-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10258444
• 关键词: 3-Dimensional; Address; Advanced Development; Algorithms; Anatomy; Animals; Anodes; Benchmarking; Cadaver; Clinical; Computer-Aided Design; Computer-Assisted Manufacturing; Dental; Dental Care; Dental Clinics; Dental Education; Dental General Practice; Dentistry; Detection; Diagnosis; Diagnostic Imaging; Diagnostic radiologic examination; Effectiveness; Electronics; Evaluation Studies; Flying body movement; Freezing; Geometry; Goals; Image; Imaging Techniques; Imaging technology; Immune; Implant; Inferior; Knowledge; Lesion; Location; Modeling; Morphologic artifacts; Motion; Noise; Operative Surgical Procedures; Optics; Oral; Oral Pathology; Outcome; Outcomes Research; Patient Care; Patient-Focused Outcomes; Patients; Performance; Phase; Photons; Play; Procedures; Productivity; Quality of Care; Radiation exposure; Rehabilitation therapy; Research Personnel; Resolution; Roentgen Rays; Role; Rotation; Saints; Scanning; Small Business Technology Transfer Research; Source; Spottings; Starvation; Structure; System; Technology; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissues; Tube; Universities; X-Ray Computed Tomography; base; clinical implementation; commercial application; cone-beam computed tomography; density; design; detector; high resolution imaging; image reconstruction; imaging modality; imaging system; improved; inferior alveolar nerve; innovation; interest; novel; photon-counting detector; point of care; prototype; reconstruction; research clinical testing; soft tissue; stem

ABSTRACT With cone-beam CT's introduction in dentistry, dental clinicians could not only have profound knowledge of oral pathology but could also enhance the access to a detailed view of the underlying structures and their relations. Dental CBCT could be justified for presurgical diagnosis, preoperative planning and preoperative transfer for oral implant rehabilitation. The image quality of CBCT, however, is suboptimal and suffers from strong image artifacts stemming from excessive x-ray scattering, limited detector performance. Spatial resolution, the most important parameter objectively defining image quality, is insufficient for many dental applications where the fine details often have to be depicted. We will develop and validate a novel dental imaging system that not only fundamentally eliminates the image quality problems and but also can produce superior image resolution in 3D images. The super-resolution dual-energy Tetrahedron Beam CT (TBCT) employs a novel multi-pixel thermionic emission x-ray (MPTEX) source with wobbling focal spots as well as an energy-resolved photon-counting detector (PCD). TBCT scans the patient with a stack of fan beams that have a very low scatter-to-primary ratio (SPR); The PCD detector can count x-ray photons without electronics noises, thus can reduce radiation exposure and dental artifacts due to photon starvation; The dual-energy capacity of PCD further eliminates beam-hardening artifacts and supports material decomposition; The flying focal spots and Time-delay-integration (TDI) detection will compensate gantry motion, and super-resolution 3D images can be reconstructed with optics-model based iterative image reconstruction (IIR). Super-resolution dental TBCT will fit in the gap of high-performance 3D imaging in dentistry, allow further advancing the productivity and quality of care in dental practice. The following specific aims have been designed to accomplish this goal: Aim 1: Develop MPTEX source with variable focal spot size and location; Aim 2: To develop and validate a super-resolution dental TBCT benchtop imaging system.

抽象的 通过Cone Beam CT在牙科中的介绍中，牙科临床医生不仅可以对 口腔病理学，但也可以增强对基础结构及其详细观点的访问 关系。牙科CBCT可以用于术前诊断，术前计划和术前诊断合理 转移口腔植入物康复。然而，CBCT的图像质量是次优的，遭受了 强大的图像伪像是由于过度X射线散射，有限的检测器性能而产生的。空间 分辨率是客观地定义图像质量的最重要参数，不足以适用于许多牙齿 通常必须描绘细节的应用程序。我们将开发并验证一种新颖的牙齿 成像系统不仅从根本上消除了图像质量问题，而且可以产生 3D图像中的出色图像分辨率。超分辨率双能四面体束CT（TBCT） 采用一种新型的多像素热发射X射线（MPTEX）源，并具有摇摆的焦点以及 能量分辨的光子计数检测器（PCD）。 TBCT用一堆风扇梁扫描患者 具有非常低的散射比率（SPR）； PCD检测器可以计算X射线光子，而无需 电子噪音，因此可以减少由于光子饥饿而导致的辐射暴露和牙文。这 PCD的双能量进一步消除了光束硬化的伪影并支持材料 分解;飞行焦点和时间延迟融合（TDI）检测将补偿龙门 运动和超分辨率3D图像可以使用基于光学模型的迭代图像重建 重建（IIR）。超分辨率牙齿TBCT将适合在高性能3D成像的差距中 牙科，允许在牙科实践中进一步提高护理的生产力和质量。下列 已经设计了具体目标来实现这一目标：目标1：开发具有可变的MPTEX源 焦点大小和位置；目标2：开发和验证超分辨率的牙齿TBCT台式 成像系统。