Hydroxyapatite Coatings Deposited Using Plasma Based Ion Implantation and Deposit

描述(申请人提供)：在第一阶段研究项目中，等离子体控制公司将通过在钛合金表面应用羟基磷灰石涂层来展示一种名为基于等离子体的离子注入和沉积(PBII&D)的先进等离子体处理技术的能力和有效性。在PBII&D中，羟基磷灰石成分在等离子体中被电离，并使用直流脉冲偏置加速到钛表面。PBII&D是一种将衬底浸入血浆中的技术，因此能够均匀地覆盖复杂的三维形状，如牙科、口腔和颅面植入物。在羟基磷灰石(HA)涂层中加入少量的银(Ag)，以提高涂层的抗菌性能。建议的技术还将用于通过离子轰击在衬底表面创建纳米级的地形，可能会提高细胞的存活率和增殖能力。HA-Ag涂层具有重要的双重用途：1)通过羟基磷灰石积极促进骨结合；2)利用银的抗菌性能抑制感染。等离子体控制公司的最终目标是为生物医学公司和研究人员提供一种基于等离子体的表面改性和涂层系统，作为生产和研究工具。等离子体控制系统将在研究的第一阶段通过在钛合金样品上涂覆一层羟基磷灰石-银涂层来证明基于等离子体的离子注入和沉积的可行性和吸引力，该涂层用于牙科、口腔、颅面和其他植入物表面。等离子体控制公司正在与科罗拉多州立大学生物医学工程学院的教职员工合作，就所应用的表面改性和涂层的有效性进行评估并提供反馈。在第二阶段，等离子体控制公司及其附属公司将把拟议的等离子技术开发成一个完整的表面改性和涂层系统。该系统将面向生物医药公司和研究机构进行营销，这些公司和研究机构可以使用该系统高效地设计和评估新型生物材料和涂层。等离子控制系统还将在内部使用拟议的系统，以提供表面改性和涂层服务。拟议的等离子处理系统主要针对美国国家牙科和颅面研究所(NIDCR)感兴趣的生物技术和生物材料主题，寻求改善用于重建患病或受伤的口腔和颅面组织的面部植入物的骨整合和抗菌性能。拟议的系统还涉及美国国立卫生研究院(NIH)广泛的纳米技术和制造倡议，在纳米级控制表面形貌，并在研究和商业环境中推进生物材料制造。 与公共健康相关：基于等离子体的离子注入和沉积(PBII&D)是一种先进的表面修饰和涂层工具，将被开发用于生物医学应用。在这项研究中，PBII&D将用于在钛植入材料上沉积掺银羟基磷灰石涂层，提高植入物与现有组织整合和抵抗细菌感染的能力。更广泛地说，建议的等离子体系统对于创造多功能和有效的生物材料和生物涂层是有用的。

DESCRIPTION (provided by applicant): In the Phase I research project, Plasma Controls will demonstrate the abilities and usefulness of an advanced plasma processing technique known as plasma based ion implantation and deposition (PBII&D) by applying hydroxyapatite coatings on titanium alloy surfaces. In PBII&D, the hydroxyapatite constituents are ionized within a plasma and accelerated toward the titanium surface using DC pulse biasing. PBII&D is a technique that immerses the substrate within the plasma, and is therefore able to uniformly coat complex three-dimensional shapes, such as dental, oral, and craniofacial implants. A small amount of silver (Ag) will be incorporated into the hydroxyapatite (HA) coating to improve the coating's antibacterial characteristics. The proposed technique will also be used to create nanoscale topography on the substrate surface using ion bombardment, possibly improving cell viability and proliferation. The HA-Ag coating has the important dual purposes of 1) actively promoting osseointegration through hydroxyapatite and 2) using the antibacterial properties of silver to inhibit infection. Plasma Controls' end-goal is to offer a plasma-based surface modification and coating system to biomedical companies and researchers as both a production and research tool. Plasma Controls will demonstrate the feasibility and attractiveness of plasma based ion implantation and deposition in the Phase I portion of the research by coating titanium alloy samples with a hydroxyapatite-silver coating intended for dental, oral, craniofacial, and other implant surfaces. Plasma Controls is collaborating with faculty in the School of Biomedical Engineering at Colorado State University to evaluate and provide feedback regarding the effectiveness of the applied surface modifications and coatings. In Phase II, Plasma Controls and its affiliates will develop the proposed plasma technology into a complete surface modification and coating system. The system will be marketed toward biomedical companies and research institutions, which may use the system to efficiently design and evaluate novel biomaterials and coatings. Plasma Controls will also use the proposed system internally to provide surface modification and coating services. The proposed plasma processing system primarily targets the biotechnology and biomaterials interest topic of the National Institute of Dental and Craniofacial Research (NIDCR), seeking to improve the osseointegrative and antibacterial properties of facial implants used for reconstruction of diseased or injured oral and craniofacial tissues. The proposed system also addresses the broad nanotechnology and manufacturing initiatives of the National Institutes of Health (NIH), controlling surface topography on the nanoscale level and advancing biomaterial fabrication in both research and commercial settings. PUBLIC HEALTH RELEVANCE: Plasma based ion implantation and deposition (PBII&D) is an advanced surface modification and coating tool that will be developed for biomedical applications. In this research, PBII&D will be used to deposit silver-doped hydroxyapatite coatings on titanium implant materials, improving an implant's ability to both integrate with existing tissue and resist bacterial infection. More generally, the proposed plasma system is useful for creating versatile and effective biomaterials and biocoatings.