Mouse Neuro-Recorder Headstage for Wide-band Microelectrode Signals

描述（由申请人提供）：AME拟开发和构建一种可用于测量和记录小鼠动作电位的多通道宽带神经记录仪头台。神经记录仪将使用微型闪存存储器在本地存储数据，并在测试后将其传输到PC。目前可用的神经记录头台仅记录小鼠的局部场电位，并且没有足够的带宽或存储器来记录动作电位数据。拟议的头部阶段将推进最先进的动态动物神经监测，并使新的神经学研究。尽管由于它们的小尺寸而传统上难以仪器化，但小鼠是理想的受试者，因为它们是可遗传操纵的。这使得小鼠能够适应其他物种（如大鼠）无法进行的科学实验。这一拟议中的设备将支持详细的动物神经学研究，支持包括阿尔茨海默氏症、亨廷顿病和癫痫在内的众多研究领域。公共卫生相关性：该设备将能够进行详细的动物神经学研究，支持许多研究领域，包括阿尔茨海默氏症，亨廷顿病和癫痫。

DESCRIPTION (provided by applicant): AME proposes to develop and build a multi-channel wideband neuro-recorder headstage that can be used for measuring and recording action potentials in mice. The neuro-recorder will use miniature flash-based memory to store data locally and transfer them to a PC post-testing. Currently available neuro-recording headstages only record local field potentials on mice and do not have enough bandwidth or memory to record action potential data. The proposed head stage will advance the state-of-the-art in ambulatory animal neurological monitoring and enable new neurological research. Despite being traditionally difficult to instrument due to their small size, mice are desirable subjects because they are genetically manipulable. This allows mice to accommodate scientific experiments that are unavailable in other species, such as rats. This proposed device will support detailed animal neurological studies, which support numerous research areas including Alzheimer's, Huntington's disease and epilepsy. PUBLIC HEALTH RELEVANCE: This device will enable detailed animal neurological studies, which support numerous research areas including Alzheimer's, Huntington's disease, and epilepsy.