Enhanced Imaging for Visual Prostheses

视觉假肢的增强成像

• 批准号: 10707243
• 负责人: GARY D HAVEY
• 金额: $ 26.82万
• 依托单位: ADVANCED MEDICAL ELECTRONICS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10707243
• 关键词: Artificial Implants; Businesses; Clinical Trials; Collaborations; Color; Communities; Compensation; Computer software; Data; Development; Diabetic Retinopathy; Disease; Doctor of Philosophy; Documentation; Educational process of instructing; Electric Stimulation; Electronics; Environment; Evaluation; Eye; Eye Injuries; Funding; Glass; Glaucoma; Grant; Head; Home; Image; Image Enhancement; Imagery; Implant; Individual; Instruction; Lead; Light; Macular degeneration; Marketing; Medical; Medical Electronics; Modality; Ocular Prosthesis; Ophthalmology; Panthera leo; Participant; Penetration; Persons; Phase; Pilot Projects; Principal Investigator; Process; Production; Prosthesis; Rehabilitation Centers; Rehabilitation therapy; Research; Resolution; Retina; Retinitis Pigmentosa; Self-Help Devices; Silicon; Small Business Innovation Research Grant; Software Validation; Specific qualifier value; System; Techniques; Technology; Temperature; Test Result; Testing; Time; Training; Training Programs; Translating; Trauma; Universities; Visible Radiation; Vision; Vision research; Visual; Visual Cortex; Visual Perception; Visual impairment; Visually Impaired Persons; Work; blind; cohort; commercialization; commercialization readiness; design; experience; imager; imaging modality; imaging system; improved; intelligent algorithm; manufacture; manufacturing systems; medical schools; multidisciplinary; optic nerve disorder; programs; prosthesis wearer; prototype; retina implantation; retinal prosthesis; sensor; verification and validation; vision aid; vision rehabilitation

Project Summary/Abstract The proposed project relates to the commercialization of a promising new thermal/visual imaging system to be used as an input modality to visual prostheses and other low vision aids. Visual prostheses, including Second Sight's Argus® II retinal prosthesis, which restores partial vision to people blinded by diseases such as retinitis pigmentosa and macular degeneration, and Second Sight's Orion® visual cortical prosthesis, which restores partial vision to people blinded by diseases such as retinitis pigmentosa, macular degeneration, glaucoma, diabetic retinopathy, eye injury/trauma, optic nerve disease etc., use cameras or other sensors to provide electrical stimulation directly to the retina or visual cortex of the user to elicit visual perception. Unfortunately, ordinary light and color information is difficult for wearers to effectively process in many important tasks with the limited perceived spatial resolution of the prostheses and other low vision aids. Current compensation techniques in reduced resolution systems apply enhancement, magnification, and panning of visible light imagery, and these techniques have utility. However, as we have convincingly demonstrated in phases I and II of the SBIR-supported development project, other types of imaging more naturally align with the limited resolution of visual prostheses in important tasks such as people finding and mobility. In this proposed CRP project, we will advance the phase II developed production-prototype system into commercial production and complete all required verification and validation testing to achieve FDA approval. Completed production systems will be distributed to prosthesis recipients who will undergo training in their use and then be allowed to evaluate the system in their home and community environment. Through these evaluations the end utility of the system in real-world use will be evaluated.

项目总结/摘要 拟议的项目涉及一种有前途的新型热/视觉成像系统的商业化， 用作视觉假体和其他低视力辅助设备的输入模态。视觉假体，包括第二 Sight的Argus® II视网膜假体，可为因视网膜炎等疾病而失明的人恢复部分视力 色素变性和黄斑变性，以及Second Sight的Orion®视觉皮层假体， 对因视网膜色素变性、黄斑变性、青光眼等疾病而失明的人的部分视力， 糖尿病视网膜病变、眼损伤/外伤、视神经疾病等，使用摄像头或其他传感器来提供 直接对用户的视网膜或视觉皮层进行电刺激以引起视觉感知。不幸的是， 普通的光和颜色信息对于佩戴者来说难以在许多重要任务中有效地处理， 假体和其他低视力辅助设备的有限的感知空间分辨率。电流补偿 降低分辨率系统中的技术应用可见光的增强、放大和平移 图像，这些技术具有实用性。然而，正如我们在第一和第二阶段令人信服地表明， 在SBIR支持的开发项目中，其他类型的成像更自然地与有限的 视觉假体在重要任务中的分辨率，例如人员查找和移动性。在本拟议CRP中， 项目，我们将推进第二阶段开发的生产原型系统进入商业生产， 完成所有要求的验证和确认测试，以获得FDA批准。完成生产 系统将分发给假肢接受者，他们将接受使用培训，然后被允许 在家庭和社区环境中评估系统。通过这些评估， 在现实世界中使用的系统将被评估。