ANTENATAL STEROID EXPOSURE AND BLOOD PRESSURE IN CHILDHOOD

我们假设极低出生体重(VLBW；1501g)婴儿产前接触糖皮质激素(ANCs) 与14岁时血压升高有关。ANC通常被给予预期的母亲 早产以提高早产儿的存活率。然而，ANC与升高的 14岁时的血压。儿童的血压与成年后的血压相关，而 后者影响心血管疾病的风险。在极低出生体重儿中，无论是存活率还是 ANC的暴露程度很高；因此，拟议的研究与一个重大的公共卫生问题有关。 动物研究表明，ANC与成年后血压升高之间存在联系，这一观点得到了支持 ANCs可能通过降低肾素-血管紧张素系统的活性来改变发育中的肾脏和大脑 (RAS)。这些变化会导致肾脏结构和功能的终身变化，并改变心血管控制， 使成年人容易患上高血压。 建议研究的对象是出生于1992-1995年间、在我们的 重症监护托儿所，并在我们的门诊新生儿随访门诊通过一年调整年龄。在……里面 该样本中ANCs暴露的频率为47%。我们建议进行以下测量：1)静息血 血压、身高和体重，在孩子14岁生日后一年内3次就诊，2)动态血压，3) 血压对运动和寒冷压力的反应，4)心率变异性，5)唾液皮质醇，6)健康水平和 体力活动，7)使用DXA扫描的身体成分，8)微量白蛋白尿，9)尿中RAS元素，以及 血和10)估计的肾小球滤过率。调整后一年的围产期暴露和生长数据 年龄将从医疗记录和计算机数据库中获得。将使用多变量分析来估计 暴露于ANCs的儿童和未暴露于ANCs的儿童之间的血压差异，调整 潜在的混杂因素和一些已知的血压相关因素。

We hypothesize that exposure to antenatal glucocorticoids (ANCS) in very low birth weight (VLBW;1501g) infants is associated with elevated blood pressure at 14 years of age. ANCS are frequently given to mothers who are expected to deliver prematurely to improve survival of premature infants. However, ANCS have been associated with elevated blood pressure at 14 years of age. Childhood blood pressure is correlated with blood pressure in adulthood, and the latter influences the risk of cardiovascular morbidity. Among VLBW babies, both the survival rate and the rate of exposure to ANCS are high; thus, the proposed research is pertinent to a significant public health concern. Supporting the proposed link between ANCS and elevated blood pressure in adulthood, animals studies indicate that ANCS alter the developing kidney and brain, possibly by decreasing the activity of the renin-angiotensin system (RAS). These alterations lead to lifelong changes in kidney structure and function and altered cardiovascular control, predisposing the adult to hypertension. The subjects for the proposed study are VLBW children who were singleton births, born 1992-1995, cared for in our intensive care nurseries, and followed in our out-patient neonatal follow up clinic through one year adjusted age. In this sample the frequency of ANCS exposure is 47%. We propose measurements of the following: 1) resting blood pressure, height, and weight, at 3 visits in the year after the child's fourteenth birthday, 2) ambulatory blood pressure, 3) blood pressure response to exercise and cold stress, 4) heart rate variability, 5) salivary cortisol, 6) level of fitness and physical activity, 7) body composition using DXA scans, 8) microalbuminuria, 9) elements of the RAS in the urine and blood, and 10) estimated glomerular filtration rate. Data on perinatal exposures and growth through one year adjusted age will be obtained from medical records and a computerized database. Multivariate analyses will be used to estimate the difference in blood pressure between children exposed to ANCS and those not exposed to ANCS, adjusting for potential confounders and a number of known correlates of blood pressure.