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Gender Differences in Neural Deficits Associated with Obstructive Sleep Apnea

阻塞性睡眠呼吸暂停相关神经缺陷的性别差异

基本信息

批准号：
7895068
负责人：
Paul M Macey
金额：
$ 23.1万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-17 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7895068
关键词：
Adult Affect Affective Age Anisotropy Anterior Apnea Area Arousal Basal Ganglia Beck depression inventory Body mass index Brain Brain Injuries Brain region Cardiovascular system Cessation of life Characteristics Cognition Comorbidity Depressed mood Development Diagnosis Diffusion Magnetic Resonance Imaging Disease Early treatment Emotional Estrogens Female Future Gender Gender Role Health Health Status Hippocampus (Brain)Incidence Injury Insula of Reil Intervention Lead Link Location Magnetic Resonance Imaging Measurement Measures Menopause Mental Depression Mental Health Modeling Morbidity - disease rate Motor Motor Neurons Nature Nerve Degeneration Obstructive Sleep Apnea Outcome Patients Physiological Pontine structure Population Postmenopause Premenopause Process Public Health Relative (related person)Relaxation Role Sensory Severities Severity of illness Sex Characteristics Site Sleep Sleep Disorders Structure Syndrome Time United States Woman Women&apos s Health base depressive symptoms disease characteristic frontal lobe gray matter improved indexing injured male memory process men mortality nerve injury neuroprotection neuropsychological psychologic public health relevance relating to nervous system sex sleep regulation therapeutic target treatment strategy

项目摘要

DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA) afflicts 20 million adults in the United States, and is associated with increased morbidity and mortality. Major male-female differences in the incidence and co-morbidities of the disorder are poorly understood. However, in preliminary studies, we found gender differences in the location and extend of neural injury associated with OSA. Since brain changes occurring with OSA may contribute to physiologic and neuropsychological characteristics, male-female differences could explain some of the gender differences in the disorder. Before attempting to related neural changes to comprehensive measures of health status, we aim to verify the gender differences in neural injury associated with OSA. We will assess 64 subjects with and without OSA, split evenly between males and females; all OSA subjects will be recently diagnosed and untreated for the sleep disorder. We will assess whole-brain structure with diffusion tensor imaging indices (fractional anisotropy and mean diffusivity), T2 relaxation time, and regional gray matter volume measures, modeled by gender and OSA status, and other potentially significant effects (sex, age, body mass index) and two-way interactions. We will additionally assess neural influences of depressive symptoms as measure by the Beck Depression Inventory-II, and OSA severity (apnea-hypopnea index). The findings will establish which brain areas show large male-female differences in neural injury associated with OSA; the functional roles of the particular structures affected will be used in future studies to select relevant health status measurements. For example, if depression-related regions are affected, follow-on studies will include comprehensive assessment of mental health status. Understanding the role of gender in brain injury occurring with OSA is important for understanding syndrome progression and development of co-morbidities, and for considering different treatment strategies for male and female patients. PUBLIC HEALTH RELEVANCE: This study will compare the brain damage between men and women with Obstructive Sleep Apnea (OSA), a sleep illness that leads to poor health and early death. We will use magnetic resonance imaging to see whether there is more or less brain injury in males than females. We will look at specific brain regions that are related to the problems that women but not men with OSA have, such as depression. If there are important differences between the sexes in the amount of damage, and places in the brain that are affected, our future studies will look to see if those brain changes explain the male-female health differences we see in OSA.

描述（由申请人提供）：阻塞性睡眠呼吸暂停 (OSA) 困扰着美国 2000 万成年人，并且与发病率和死亡率增加有关。人们对这种疾病的发病率和合并症的主要男女差异知之甚少。然而，在初步研究中，我们发现与 OSA 相关的神经损伤的位置和范围存在性别差异。由于 OSA 发生的大脑变化可能会影响生理和神经心理特征，因此男女差异可以解释该疾病的一些性别差异。在尝试将神经变化与健康状况的综合测量联系起来之前，我们的目的是验证与 OSA 相关的神经损伤的性别差异。我们将评估 64 名患有或不患有 OSA 的受试者，其中男性和女性各占一半；所有 OSA 受试者最近都会被诊断出睡眠障碍且未经治疗。我们将使用扩散张量成像指数（分数各向异性和平均扩散率）、T2 弛豫时间和区域灰质体积测量来评估全脑结构，以性别和 OSA 状态建模，以及其他潜在的显着影响（性别、年龄、体重指数）和双向相互作用。我们还将通过贝克抑郁量表 II 和 OSA 严重程度（呼吸暂停低通气指数）来评估抑郁症状对神经的影响。研究结果将确定哪些大脑区域在与 OSA 相关的神经损伤方面表现出巨大的男女差异；受影响的特定结构的功能作用将在未来的研究中用于选择相关的健康状况测量。例如，如果与抑郁症相关的区域受到影响，后续研究将包括对心理健康状况的综合评估。了解性别在 OSA 脑损伤中的作用对于了解综合征的进展和合并症的发展以及考虑针对男性和女性患者的不同治疗策略非常重要。公共健康相关性：这项研究将比较阻塞性睡眠呼吸暂停 (OSA) 对男性和女性的脑损伤，阻塞性睡眠呼吸暂停是一种导致健康状况不佳和过早死亡的睡眠疾病。我们将使用磁共振成像来观察男性的脑损伤是否比女性多或少。我们将研究与女性而非男性患有 OSA 的问题相关的特定大脑区域，例如抑郁症。如果两性之间的损伤程度以及受影响的大脑部位存在重大差异，我们未来的研究将看看这些大脑变化是否可以解释我们在 OSA 中看到的男女健康差异。