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Common-Path OCT for Real Time Imaging in Minimally Invasive Neurosurgery

用于微创神经外科实时成像的共路 OCT

基本信息

批准号：
7895098
负责人：
Jin U Kang
金额：
$ 19.99万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-16 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7895098
关键词：
3-Dimensional Address Animal Model Back Biopsy Blood Blood Vessels Brain Brain Neoplasms Brain imaging Characteristics Corticospinal Tracts Data Development Devices Endoscopes Evaluation Fiber Optics Freedom Functional Imaging Human Image Imaging technology Injection of therapeutic agent Lasers Length Location Measures Medical Methods Modeling Monitor Nature Needles Operative Surgical Procedures Optical Coherence Tomography Oxygen Oxygen saturation measurement Penetration Performance Process Relative (related person)Research Resolution Safety Sampling Scanning Signal Transduction Specimen Speed Staging Structure Surface Surgeon System Technology Therapeutic Three-Dimensional Imaging Time Tissues Tumor-Derived Work arm base cost effective design flexibility in vivo instrumentation interest millimeter minimally invasive neurosurgery novel novel strategies optical fiber public health relevance sensor tool tumor vibration

项目摘要

DESCRIPTION (provided by applicant): We propose to develop functional imaging and sensing system combining common-path Fourier-Domain OCT with oxymetry for assisting in neurosurgery. We plan to develop this technology to enhance the safety and efficacy of endoscopic neurosurgery, needle brain biopsies, and anatomical target localization. This subspecialty requires very precise and delicate manipulation of surgical tools through tight spaces with surrounding critical tissues. Therefore, there is high potential value with providing real time intra-operative imaging and oxymetry sensing information which indicates the location of critical anatomical structures such as normal brain-tumor interface, corticospinal tract, and blood vessels, both tumor derived and normal. In order to achieve this objective, the system will have endoscopic micro-optical-fiber sensor that can be fully integrated with existing neurosurgical tools and can measure tissue boundaries relative to surgical tools, blood oxygenation level of surrounding tissues, and identify blood vessels within the tissue volume. We will evaluate the performance of this system for neurosurgery using animal models and human cadaveric specimens. Our proposed approach is novel in several ways. First, this represents the first study of use of a common-path OCT to obtain endoscopic imaging of brain structures and pathological brain abnormalities (in vivo tumor model). Second, this is the first common-path endoscopic sensor integrated with neurosurgical tools in hopes of help guiding endoscopic tools and provides critical tissue avoidance. Third, we will provide first evaluation of the common-path OCT implemented surgical tool for neurosurgery applications. PUBLIC HEALTH RELEVANCE: The proposed work is designed to address and enhance the safety associated with endoscopic neurosurgery by providing surgeons with real-time critical anatomical structure information during surgery.

描述（由申请人提供）：我们建议开发功能成像和传感系统，将共路径傅里叶域OCT与氧测量相结合，以协助神经外科。我们计划开发这项技术，以提高内窥镜神经外科、针脑活检和解剖目标定位的安全性和有效性。这个亚专业需要非常精确和微妙的操作手术工具通过狭窄的空间周围的关键组织。因此，提供实时术中成像和氧测传感信息，显示正常脑肿瘤界面、皮质脊髓束和血管等关键解剖结构的位置，无论是肿瘤源性的还是正常的，具有很高的潜在价值。为了实现这一目标，该系统将具有内窥镜微光纤传感器，可以与现有的神经外科工具完全集成，可以测量相对于手术工具的组织边界，周围组织的血氧水平，并识别组织体积内的血管。我们将使用动物模型和人类尸体标本来评估该系统在神经外科中的性能。我们提出的方法在几个方面是新颖的。首先，这是首次使用共径OCT获得脑结构和病理性脑异常（体内肿瘤模型）的内窥镜成像。其次，这是第一个与神经外科工具集成的共径内窥镜传感器，希望有助于指导内窥镜工具并提供关键的组织避免。第三，我们将首次评估共径OCT实现的神经外科手术工具的应用。公共卫生相关性：拟议的工作旨在通过向外科医生提供手术过程中关键解剖结构的实时信息来解决和提高内窥镜神经外科手术的安全性。

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（5）

Real-time 3D and 4D Fourier domain Doppler optical coherence tomography based on dual graphics processing units.

DOI：
10.1364/boe.3.002162
发表时间：
2012-09-01
期刊：
Biomedical optics express
影响因子：
3.4
作者：
Huang Y;Liu X;Kang JU
通讯作者：
Kang JU

Modified compressive sensing optical coherence tomography with noise reduction.

DOI：
10.1364/ol.37.004209
发表时间：
2012-10-15
期刊：
Optics letters
影响因子：
3.6
作者：
Xu D;Vaswani N;Huang Y;Kang JU
通讯作者：
Kang JU

Extravascular optical coherence tomography: evaluation of carotid atherosclerosis and pravastatin therapy.

DOI：
10.1161/strokeaha.113.002970
发表时间：
2014-04
期刊：
Stroke
影响因子：
8.3
作者：
Wicks RT;Huang Y;Zhang K;Zhao M;Tyler BM;Suk I;Hwang L;Ruzevick J;Jallo G;Brem H;Pradilla G;Kang JU
通讯作者：
Kang JU

Compressive SD-OCT: the application of compressed sensing in spectral domain optical coherence tomography.