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Anticonvulsant effects of novel concentric ring electrode electrical stimulation

新型同心环电极电刺激的抗惊厥作用

基本信息

批准号：
7837748
负责人：
Walter Grant Besio
金额：
$ 21.6万
依托单位：
UNIVERSITY OF RHODE ISLAND
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-05-15 至 2012-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7837748
关键词：
Adverse drug effect Age American Anticonvulsants Area Behavior Behavioral Brain Brain Injuries Cell Count Cessation of life Cholinergic Agonists Chronic Computer Simulation Computer software Dermal Development Diazepam Electric Stimulation Electrodes Electroencephalography Epilepsy Evaluation Foundations Future Generations Goals Head Histology Hospitals Hour Image Image Analysis Implant Infiltration Inflammation Intervention Intractable Epilepsy Investigation Kindling (Neurology)Laboratory Rat Leukocytes Lymphocyte Measures Methods Modeling Morbidity - disease rate Motor Necrosis Neurons Nuclear Operative Surgical Procedures Patients Pattern Pentylenetetrazole Phase Pilocarpine Prevention Process Rattus Research Research Personnel Risk Safety Scalp structure Seizures Severities Staining method Stains Status Epilepticus Structure Surface Techniques Testing Therapeutic Tissues Transcutaneous Electric Nerve Stimulation Treatment Cost Update base brain tissue comparative efficacy cresyl violet density design improved innovation minimally invasive mortality mossy fiber nervous system disorder novel public health relevance research study response

项目摘要

DESCRIPTION (provided by applicant): Epilepsy, characterized by recurring seizures, is one of the most prevalent neurological disorders in the U.S. Despite decades of research, new anticonvulsant drugs, and advances in surgical therapy, a large number of patients suffer from intractable epilepsy or the side effects of drugs or surgical treatment. Brain stimulation for epilepsy has shown promise but requires further research. The long-term goal of the investigators is to develop effective non-invasive and minimally invasive electrical stimulation therapies for intractable epilepsy. Non-invasive transcutaneous electrical stimulation (TcES) via unique concentric ring electrodes on the scalp surface is proposed as an innovative approach to seizure control. Noninvasive methods for stimulation-induced seizure control avoid complications associated with intracerebral implants. The objective of this R21 project is to investigate in laboratory rats anticonvulsant and safety of TcES via concentric ring electrodes on the scalp surface. Based on promising preliminary results, three hypotheses are behind this research: " Hypothesis 1: TcES via concentric ring electrodes on the scalp surface has anticonvulsant effects. " Hypothesis 2: {The suppression of pilocarpine (PILO)-induced status epilepticus (SE) by TcES via concentric ring electrodes reduces SE-provoked neuronal death.} " Hypothesis 3: Effective TcES parameters do not cause damage to rat scalp or brain tissue. To achieve the project objective and test the hypothesis, three specific aims are set: " Aim 1: Analyze the effects of TcES via concentric ring electrodes on electrographic activity, behavioral manifestations, severity, latency to onset, and threshold of pentylenetetrazole (PTZ)-induced seizures in rats. (test Hypothesis 1) " Aim 2: {Verify the suppression of PILO-induced SE by TcES via concentric ring electrodes through histopathological evaluation of neuronal integrity.} (test Hypothesis 2) " Aim 3: Assess potential tissue damage due to TcES via concentric ring electrodes through histomorphological analysis. The integrity of both scalp and brain tissue will be assessed. (test Hypothesis 3) As an initial phase of our research, this R21 project lays the foundation for future investigations of TcES in additional areas of importance. PUBLIC HEALTH RELEVANCE: If the proposed research is successful, in the future TcES may promise a viable non-invasive therapy for intractable epilepsy. A non-invasive therapeutic strategy for bedside and/or out-of-hospital intervention can significantly improve morbidity and mortality, as well as reduce risk and cost of treatment.

描述（由申请人提供）：癫痫的特征是反复发作，是美国最常见的神经系统疾病之一。尽管经过数十年的研究，新的抗惊厥药物和手术治疗的进展，但大量患者患有难治性癫痫或药物或手术治疗的副作用。脑刺激治疗癫痫已经显示出希望，但需要进一步的研究。研究人员的长期目标是开发有效的非侵入性和微创电刺激治疗顽固性癫痫。无创经皮电刺激（TcES）通过独特的同心环电极在头皮表面被提出作为一种创新的方法来控制癫痫发作。非侵入性方法刺激诱导癫痫控制避免并发症与脑内植入物。本R21项目的目的是通过在头皮表面上的同心环电极在实验室大鼠中研究TcES的抗惊厥和安全性。基于有希望的初步结果，这项研究背后有三个假设：“假设1：通过头皮表面的同心环电极的TcES具有抗惊厥作用。 “假设2：{TcES通过同心环电极对毛果芸香碱（PILO）诱导的癫痫持续状态（SE）的抑制减少了SE引起的神经元死亡。}假设3：有效的TcES参数不会对大鼠头皮或脑组织造成损伤。为了实现项目目标并验证假设，设定了三个具体目标：“目标1：分析通过同心环电极TcES对大鼠戊四唑（PTZ）诱导癫痫发作的电图活动、行为表现、严重程度、发作潜伏期和阈值的影响。 (test假设1）“目的2：{通过神经元完整性的组织病理学评价，验证TcES通过同心环电极对PILO诱导SE的抑制。} (test假设2）“目的3：通过组织形态学分析，通过同心环电极评估TcES引起的潜在组织损伤。将评估头皮和脑组织的完整性。 (test假设3）作为我们研究的初始阶段，这个R21项目为将来在其他重要领域研究TcES奠定了基础。公共卫生相关性：如果这项研究成功，TcES有望成为治疗难治性癫痫的一种可行的非侵入性疗法。床旁和/或院外干预的非侵入性治疗策略可显著改善发病率和死亡率，并降低治疗风险和成本。

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（1）

Feasibility of recording high frequency oscillations with tripolar concentric ring electrodes during pentylenetetrazole-induced seizures in rats.

在戊四唑诱导大鼠癫痫发作期间用三极同心环电极记录高频振荡的可行性。

DOI：
10.1109/embc.2012.6346991
发表时间：
2012
期刊：
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子：
0
作者：
Makeyev,Oleksandr;Liu,Xiang;Wang,Liling;Zhu,Zhenghan;Taveras,Aristides;Troiano,Derek;Medvedev,AndreiV;Besio,WalterG
通讯作者：
Besio,WalterG

Transcranial Focal Electrical Stimulation Modifies Biogenic Amines' Alterations Induced by 6-Hydroxydopamine in Rat Brain.

DOI：
10.3390/ph14080706
发表时间：
2021-07-21
期刊：
Pharmaceuticals (Basel, Switzerland)
影响因子：
0
作者：
Santana-Gómez CE;Pérez-Pérez D;Fonseca-Barriendos D;Arias-Carrión O;Besio W;Rocha L
通讯作者：
Rocha L

Sensor integration of multiple tripolar concentric ring electrodes improves pentylenetetrazole-induced seizure onset detection in rats.

多个三极同心环电极的传感器集成改善了戊四唑诱导的大鼠癫痫发作检测。