Nutrient and hormone delivery to muscle: interactions between insulin and exercise

营养和激素输送到肌肉：胰岛素和运动之间的相互作用

• 批准号: nhmrc : 352600
• 负责人: Dr Stephen Richards
• 金额: $ 20.3万
• 依托单位: Antarctic Climate and Ecosystems CRC, University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nutrient-hormone-delivery-insulin-exercise/99676
• 关键词: Nutrient; hormone; delivery; muscle; interactions

Exercise is known to be beneficial in the treatment and prevention of Type 2 diabetes and in particular muscle insulin resistance. Also, exercise and insulin share similar acute actions on muscle. Firstly, muscle contraction has a well established action to increase glucose uptake, and secondly, both muscle contraction and insulin act to increase capillary recruitment. This latter phenomenon is thought to enhance nutrient delivery and waste product removal. There is evidence that the increase in capillary flow due to muscle contraction is accompanied by increases in total blood flow. For insulin action we now have preliminary data to indicate that capillary recruitment occurs within a 5-10 min application of a physiologic dose of insulin independent of a change in total blood flow suggesting a redistribution of flow. Muscle contraction also increases capillary recruitment and it raises the question of whether similar mechanisms underlie insulin- and muscle contraction-induced capillary recruitment or whether there are distinct and complementary pathways. In this project we plan to define the mechanisms responsible for contraction- and insulin-induced capillary recruitment in muscle. We hypothesize that similar mechanisms are operative, with both insulin and muscle contractions acting via NO-dependent mechanisms. Because of capillary reserve, and different initial steps of the signalling systems stimulated by insulin and exercise, capillary recruitment by combined contraction and insulin stimuli will be additive at both sub maximal and perhaps at maximal insulin pathway stimulation. Signalling mechanisms will be compared and the role of non-nutritive route as a flow reserve assessed.

已知运动有益于治疗和预防2型糖尿病，特别是肌肉胰岛素抵抗。此外，运动和胰岛素对肌肉的急性作用相似。首先，肌肉收缩具有增加葡萄糖摄取的良好作用，其次，肌肉收缩和胰岛素都起到增加毛细血管募集的作用。后一种现象被认为增强了营养物的输送和废物的去除。有证据表明，由于肌肉收缩引起的毛细血管流量的增加伴随着总血流量的增加。对于胰岛素的作用，我们现在有初步的数据表明，毛细血管募集发生在5-10分钟内的生理剂量的胰岛素的应用独立于总血流量的变化，表明流量的重新分布。肌肉收缩也会增加毛细血管募集，这就提出了一个问题，即胰岛素和肌肉收缩诱导的毛细血管募集是否存在类似的机制，或者是否存在不同的互补途径。在这个项目中，我们计划确定负责收缩和胰岛素诱导的肌肉毛细血管募集的机制。我们假设类似的机制是可操作的，胰岛素和肌肉收缩通过NO依赖性机制起作用。由于毛细血管储备，以及胰岛素和运动刺激的信号传导系统的不同初始步骤，通过组合收缩和胰岛素刺激的毛细血管募集在次最大和可能在最大胰岛素途径刺激下都是相加的。将比较信号机制，并评估非营养途径作为血流储备的作用。