BIODIVERSITY CONSERVATION AND DRUG DISCOVERY IN MADAGASCAR

马达加斯加的生物多样性保护和药物发现

• 批准号: 7907275
• 负责人: DAVID GEORGE IAN KINGSTON
• 金额: $ 23.24万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7907275
• 关键词: Affect; Agrochemicals; Area; Biocompatible Materials; Biodiversity; Biological Assay; Biological Factors; Botanicals; Botany; Cancer Immunology Science; Cardiology; Chemistry; Communities; Country; Development; Disease; Economic Development; Endocrinology; Exhibits; Financial compensation; Fractionation; Funding; Gastroenterology; Goals; Immunology; Institutes; Intellectual Property; International; Journals; Knowledge; Madagascar; Malaria; Marines; Methods; Mission; Missouri; Modeling; Natural Products Chemistry; Natural Resources; Neurology; Pharmacologic Substance; Plants; Population; Property Rights; Publishing; Pulmonology; Research; Research Infrastructure; Research Institute; Research Support; Sales; Scientist; Students; Surveys; Techniques; Training; Tuberculosis; United States; Universities; Virginia; Work; drug discovery; forest; improved; interest; international center; marine organism; microbial; nervous system disorder; novel; oncology; programs; soil sampling

DESCRIPTION (provided by applicant): The overall goals of this International Cooperative Biodiversity group are to achieve the threefold mission of biodiversity conservation, economic development, and drug discovery in Madagascar. The proposed research integrates the work of seven different associate programs into a coherent whole to achieve these goals. The drug discovery mission will have a threefold approach to collecting biomaterials in Madagascar. Plants will be collected by botanists from Missouri Botanical Garden (MBG) Conservation International (CI) and the Centre National d'Application et des Recherches Pharmaceutiques (CNARP). Marine organisms will be collected by teams from Centre National de Recherches sur l'Environnement (CNRE) and Centre National de Recherches Oceanographiques (CNRO). Microbial strain isolation from soil samples will be carried out by scientists from CNARP after receiving training at DowAgroSciences (DAS). The plants will be extracted by workers at the CNARP, and the marine organisms will be extracted by workers at CNRE and CNRO. Subsequent bioassays, fractionation studies, and chemistry will be carried out by CNARP, Eisai Research Institute (ERI), DAS and Virginia Polytechnic Institute and State University (VPISU) in the interest areas of cancer, immunology, malaria, neurological disease, tuberculosis, and agrochemistry, and royalties will be paid to Madagascar on sales of any pharmaceuticals or agrochemicals that are developed from this work. Pure microbial strains will be cultured by one or both of the industrial partners and active compounds of interest will then be isolated from these culture broths. In addition to the drug discovery work outlined above, the Group will also carry out economic development and biodiversity conservation initiatives in Madagascar. In Madagascar the work will include the completion of biodiversity surveys of well-defined forest preserves, as well as training in botanical methods at MBG, training in microbial techniques at DAS, and training in natural product isolation at VPISU. The work will also involve local stakeholders in decisions about the use of upfront funds contributed by DAS and ERI.

描述(申请人提供)：这个国际合作生物多样性组织的总体目标是实现马达加斯加生物多样性保护、经济发展和药物发现的三重使命。这项拟议的研究将七个不同的协理项目的工作整合为一个连贯的整体，以实现这些目标。药物发现任务将采取三种方法在马达加斯加收集生物材料。植物将由密苏里州植物园(MBG)、保护国际(CI)和国家应用与研究药物中心(CNARP)的植物学家收集。海洋生物将由L环境国家研究中心和国家海洋研究中心的团队收集。在接受了DowAgroSciences(DAS)的培训后，CNARP的科学家将从土壤样本中分离微生物菌株。这些植物将由CNARP的工人提取，海洋生物将由CNRE和CNRO的工人提取。后续的生物分析、分级研究和化学将由CNARP、卫材研究所(ERI)、DAS和弗吉尼亚理工学院和州立大学(VPISU)在癌症、免疫学、疟疾、神经疾病、结核病和农业化学等感兴趣的领域进行，并将向马达加斯加支付从这项工作中开发的任何药品或农用化学品的销售特许权使用费。工业伙伴中的一个或两个将培养纯微生物菌株，然后从这些发酵液中分离出感兴趣的活性化合物。除上文概述的药物发现工作外，该小组还将在马达加斯加开展经济发展和生物多样性保护倡议。在马达加斯加，这项工作将包括完成对明确的森林保护区的生物多样性调查，以及在MBG进行植物学方法培训，在DAS进行微生物技术培训，在VPISU进行天然产品分离培训。这项工作还将使当地利益攸关方参与关于使用发展司和应急倡议提供的前期资金的决定。