BIODIVERSITY UTILIZATION IN MADAGASCAR AND SURINAME

马达加斯加和苏里南的生物多样性利用

• 批准号: 2722192
• 负责人: DAVID GEORGE IAN KINGSTON
• 金额: $ 61.3万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2722192
• 关键词: Africa; South America; alternative medicine; angiogenesis inhibitors; antibiotics; antifungal agents; antiinfective agents; antimalarial agents; antineoplastics; antitubercular agents; antiviral agents; bioassay; chemical structure; cooperative study; drug design /synthesis /production; drug screening /evaluation; ethnic group; field study; folk medicine; hot climate; information dissemination; international cooperation; medicinal plants; pesticides; plant ecology; plant extracts; training; tropical medicine; workshop

The overall goals of this International Cooperative Biodiversity group are to achieve the threefold mission of biodiversity conservation, economic development and drug discovery in the countries of Suriname and Madagascar. The proposed research integrates the work of seven different associate programs into a coherent whole to achieve these goals. In Suriname plants will be collected primarily by teams from Conservation International, with some recollections being done by botanists from Missouri Botanic Garden (MBG). The plants will be extracted by workers at the Surinamese company Bedrijf Geneesmiddelen Voorziening Suriname (BGVS) and then bioassays for both pharmaceutical and agrochemical activity will be carried out BGVS, a Bristol-Myers Squibb Pharmaceutic Research Institute (BMS), at Virginia Polytechnic Institute and State University (VPISU) and at DowElanco. Activities of interest include antibacterial, anti-cancer, anti-mycobacterial, anti-malarial, anti-fungal, cardiovascular, CNS, and anti-viral activities in the pharmaceutical area, and insecticidal and anti-fungal activities in the agrochemical area. Active extracts will be fractionated and the structures of active compounds determined at BGVS, VPISU, or BMS, depending on the activity found. Compounds with novel structure and/or novel activities that are of interest for drug development will be patented and subjected to further testing at BMS or DowElanco, depending on the activity. Royalties will be paid to Suriname on sales of compounds that proceed to clinical or agrochemical use. In Madagascar, plants will be collected primarily by botanists from Missouri Botanical Garden (MBG), with simultaneous ethnobotanical work being carried out by teams from Conservation International. The plants will be extracted by workers at the Centre National d'Application et des Recherches Pharmaceutiques (CNARP). Subsequent bioassays, fractionation studies, and chemistry will be carried out by CNARP, BMS, DowElanco, and VPISU, in the interest areas described above, and royalties will be paid to Madagascar on sales of any pharmaceuticals or agrochemicals that are developed from this work. In addition to the drug discovery work outlined above, the Group will also carry out economic development and biodiversity conservation initiative in both Suriname and Madagascar. In Suriname the work will include documentation of traditional ethnobotanical knowledge and training in both modern systems such as GIS and in traditional knowledge through the "Shaman's Apprentice" program. In Madagascar the work will include the completion of biodiversity surveys of well-defined forest preserves, as well as training in botanical methods at Missouri Botanical Garden.

国际生物多样性合作组织的总体目标是 为了实现生物多样性保护、经济发展和环境保护的三重使命， 苏里南和其他国家的药物开发和发现 Madagascar.这项研究整合了七个不同的工作， 将计划关联成一个连贯的整体，以实现这些目标。 在苏里南，植物将主要由保护组织的团队收集。 国际上，一些植物学家从 密苏里州植物园。这些植物将由工人在 苏里南Bedrijf Geneesmiddelen Voorziening公司（BGVS） 然后对药物和农业化学活性进行生物测定， BGVS，百时美施贵宝制药研究 弗吉尼亚理工学院和州立大学 （VPISU）和DowElanco。感兴趣的活性包括抗菌， 抗癌，抗分枝杆菌，抗疟疾，抗真菌， 心血管、中枢神经系统和抗病毒活性， 以及在农业化学领域的杀虫和抗真菌活性。 活性提取物将被分级，并且活性组分的结构将被确定。 在BGVS、VPISU或BMS测定的化合物，具体取决于活性 found.具有新结构和/或新活性的化合物， 对药物开发的兴趣将获得专利，并受到进一步的审查。 在BMS或DowElanco进行测试，具体取决于活动。版税将 向苏里南支付的用于临床的化合物销售费用，或 农用化学品使用。 在马达加斯加，植物将主要由植物学家收集， 密苏里州植物园（MBG），同时进行民族植物学工作 由国际自然保护组织的团队进行。植物 将由国家应用与开发中心的工人提取 Recherches Pharmaceutiques（CNARP）。随后的生物测定、分馏 研究和化学将由CNARP，BMS，DowElanco和 VPISU，在上述感兴趣的领域，并将支付特许权使用费 向马达加斯加出售任何药品或农用化学品， 从这项工作中发展起来的。 除上述药物研发工作外，本集团亦将 开展经济发展和生物多样性保护行动， 苏里南和马达加斯加。在苏里南，工作将包括 传统民族植物学知识的文献记录和 现代系统，如地理信息系统和传统知识， 《巫师学徒》节目在马达加斯加，工作将包括 完成对明确界定的森林保护区的生物多样性调查， 以及在密苏里州植物园接受植物学方法的培训。