BIODIVERSITY UTILIZATION IN MADAGASCAR AND SURINAME

这个国际生物多样性合作组织的总体目标是 要实现生物多样性保护、经济发展的三重使命 苏里南和苏里南国家的发展和药物发现 马达加斯加。这项拟议的研究整合了七个不同的 将项目关联成一个连贯的整体，以实现这些目标。 在苏里南，植物将主要由保护组织的团队收集 国际，一些回忆是由植物学家从 密苏里州植物园(MBG)。这些植物将由工人在 苏里南Bedrijf Geneesmiddelen Voorzining Suriname(BGVS)公司 然后，药物和农用化学活性的生物测定将 进行百时美施贵宝制药研究的BGVS 弗吉尼亚理工学院和州立大学(BMS) (VPISU)和DowElanco。感兴趣的活动包括抗菌， 抗癌，抗分枝杆菌，抗疟疾，抗真菌， 制药领域的心血管、中枢神经系统和抗病毒活性， 以及农化地区的杀虫和抗真菌活性。 活性提取物将被分级，活性提取物的结构 BGV、VPISU或BMS测定的化合物，取决于活性 找到了。具有新结构和/或新活性的化合物 对药物开发的兴趣将获得专利，并受到进一步 在BMS或DowElanco进行测试，具体取决于活动。版税将是 向苏里南支付的销售进入临床或临床的化合物 农用化学品的使用。 在马达加斯加，植物将主要由植物学家从 密苏里州植物园(MBG)，同时进行民族植物学工作 由国际自然保护组织的团队进行。这些植物 将由国家应用和数据处理中心的工作人员提取 研究制药公司(CNARP)。随后的生物测定、分级 研究和化学将由CNARP，BMS，DowElanco和 VPISU，在上述感兴趣的领域，将支付特许权使用费 向马达加斯加销售任何符合以下条件的药品或农用化学品 从这项工作发展而来的。 除了上文概述的药物发现工作外，该小组还将 实施经济发展和生物多样性保护倡议 苏里南和马达加斯加都是。在苏里南的工作将包括 记录传统民族植物学知识和这两方面的培训 现代系统，如地理信息系统和传统知识，通过 《萨满的学徒》节目。在马达加斯加的工作将包括 完成对明确界定的森林保护区的生物多样性调查，如 以及密苏里州植物园的植物学方法培训。

The overall goals of this International Cooperative Biodiversity group are to achieve the threefold mission of biodiversity conservation, economic development and drug discovery in the countries of Suriname and Madagascar. The proposed research integrates the work of seven different associate programs into a coherent whole to achieve these goals. In Suriname plants will be collected primarily by teams from Conservation International, with some recollections being done by botanists from Missouri Botanic Garden (MBG). The plants will be extracted by workers at the Surinamese company Bedrijf Geneesmiddelen Voorziening Suriname (BGVS) and then bioassays for both pharmaceutical and agrochemical activity will be carried out BGVS, a Bristol-Myers Squibb Pharmaceutic Research Institute (BMS), at Virginia Polytechnic Institute and State University (VPISU) and at DowElanco. Activities of interest include antibacterial, anti-cancer, anti-mycobacterial, anti-malarial, anti-fungal, cardiovascular, CNS, and anti-viral activities in the pharmaceutical area, and insecticidal and anti-fungal activities in the agrochemical area. Active extracts will be fractionated and the structures of active compounds determined at BGVS, VPISU, or BMS, depending on the activity found. Compounds with novel structure and/or novel activities that are of interest for drug development will be patented and subjected to further testing at BMS or DowElanco, depending on the activity. Royalties will be paid to Suriname on sales of compounds that proceed to clinical or agrochemical use. In Madagascar, plants will be collected primarily by botanists from Missouri Botanical Garden (MBG), with simultaneous ethnobotanical work being carried out by teams from Conservation International. The plants will be extracted by workers at the Centre National d'Application et des Recherches Pharmaceutiques (CNARP). Subsequent bioassays, fractionation studies, and chemistry will be carried out by CNARP, BMS, DowElanco, and VPISU, in the interest areas described above, and royalties will be paid to Madagascar on sales of any pharmaceuticals or agrochemicals that are developed from this work. In addition to the drug discovery work outlined above, the Group will also carry out economic development and biodiversity conservation initiative in both Suriname and Madagascar. In Suriname the work will include documentation of traditional ethnobotanical knowledge and training in both modern systems such as GIS and in traditional knowledge through the "Shaman's Apprentice" program. In Madagascar the work will include the completion of biodiversity surveys of well-defined forest preserves, as well as training in botanical methods at Missouri Botanical Garden.