Diet and Exercise in Type 2 Diabetes
2 型糖尿病的饮食和运动
基本信息
- 批准号:7878593
- 负责人:
- 金额:$ 79.77万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-01 至 2012-06-30
- 项目状态:已结题
- 来源:
- 关键词:AbdomenAccountingAdverse effectsAerobicAffectArtsBlood GlucoseBlood VesselsBody CompositionBody Weight decreasedCardiacCardiovascular DiseasesCardiovascular systemCarotid ArteriesCause of DeathCentral obesityClinicalColorComplementControl GroupsDEXADataDevelopmentDiabetes MellitusDietEchocardiographyEnrollmentEpidemicEventExerciseFatty acid glycerol estersFunctional disorderFundingFutureHealthHeart failureImageIndividualInflammationInsulin ResistanceKnowledgeLeftLeft Ventricular FunctionLeptinLinkMagnetic Resonance ImagingMeasuresMediatingMorbidity - disease rateMyocardial InfarctionNon-Insulin-Dependent Diabetes MellitusNurses&apos Health StudyObesityOutcomeOverweightPeripheralPersonsPhysiologic pulsePulse PressureRandomizedRandomized Controlled TrialsReportingResearch PersonnelRiskRisk FactorsSex CharacteristicsStructureTestingTissuesUltrasonographyUnited StatesUnited States National Institutes of HealthVasodilationVasodilator AgentsVentricularVisceralWomanabdominal fatadiponectinblood glucose regulationcardiovascular disorder riskdiabeticdiet and exercisefitnessglycemic controlheart disease riskimaging modalityimprovedindexinginnovationinsightinsulin sensitivitymenmortalitynovelrandomized trialreactive hyperemiaresponsesedentarysubcutaneoustonometrywaist circumference
项目摘要
DESCRIPTION (provided by applicant): Type 2 diabetes, a condition that is largely due to obesity and physical inactivity, has adverse effects on cardiac and peripheral vascular structure and function. Cardiovascular disease is the leading cause of death among persons with diabetes. The cardiovascular consequences of diabetes include left ventricular diastolic dysfunction, endothelial vasodilator dysfunction, and increased vascular stiffness, each of which is an early marker of future cardiovascular disease. Obesity, and particularly abdominal fatness, contributes to the development of diabetes, and is a factor that increases cardiovascular disease risk. Caloric reduction and exercise are clinically important for weight loss, increasing fitness, and improving blood glucose control. However, to our knowledge, there are no randomized trials in overweight and obese persons with diabetes in which the effect of diet and exercise on general and abdominal fatness, fitness, cardiac and peripheral vascular structure and function, and cardiac disease risk factors has been examined together. The primary aim is to test the hypothesis that a weight loss diet and exercise will each reduce abdominal fatness in overweight persons with type 2 diabetes. We also hypothesize that diet plus exercise will produce greater reductions in abdominal fatness. To test our hypotheses, we will randomize 140 overweight and obese persons with type 2 diabetes into a diet, exercise, diet plus exercise, or a control group for 6 months. The second aim to test the hypothesis that reductions in fatness will mediate improvements in endothelial vasodilator function, left ventricular diastolic function, and vascular stiffness, and that by producing greater reductions in fatness, diet plus exercise will be more effective than diet or exercise alone for improving cardiovascular parameters. The third aim is examine mechanisms by which diet, exercise, and abdominal fatness affect cardiovascular outcomes. These mechanisms include systemic inflammation, insulin sensitivity, aerobic and strength fitness, glycemic control, leptin, adiponectin, and cardiovascular disease risk factors. We will enroll an equal number of men and women, and in secondary analyses, we will explore gender differences in response to treatment. This study will provide novel insights into the mechanisms by which diet and exercise reduce abdominal fatness and improve cardiovascular health in overweight and obese persons with type 2 diabetes.Type 2 diabetes, which is largely due to obesity, and particularly abdominal obesity, and physical inactivity, is an increasing at an epidemic rate in the United States, and markedly increases the risk of cardiovascular disease. Persons with diabetes have abnormalities in cardiovascular structure and function that appear even before an individual suffers from a cardiac event such as a heart attack or developing heart failure. This study will examine the extent to which diet and exercise, either each alone or in combination, reduces abdominal fatness and improves cardiovascular parameters that are early markers of cardiovascular disease in overweight and obese persons with type 2 diabetes.
描述(由申请人提供):2型糖尿病是一种主要由肥胖和缺乏体力活动引起的疾病,对心脏和外周血管结构和功能有不良影响。心血管疾病是糖尿病患者死亡的主要原因。糖尿病的心血管后果包括左心室舒张功能障碍、内皮血管舒张功能障碍和血管僵硬度增加,其中每一个都是未来心血管疾病的早期标志。肥胖,特别是腹部肥胖,有助于糖尿病的发展,是增加心血管疾病风险的一个因素。减少卡路里和运动在临床上对减肥、增加健康和改善血糖控制很重要。然而,据我们所知,还没有在超重和肥胖的糖尿病患者中进行的随机试验,其中饮食和运动对全身和腹部肥胖,健身,心脏和外周血管结构和功能以及心脏病危险因素的影响一起进行了检查。主要目的是检验减肥饮食和运动将分别减少超重2型糖尿病患者腹部脂肪的假设。我们还假设,饮食加运动将产生更大的减少腹部脂肪。为了验证我们的假设,我们将140名超重和肥胖的2型糖尿病患者随机分为饮食、运动、饮食加运动或对照组,为期6个月。第二个目的是检验以下假设:肥胖的减少将介导内皮血管舒张功能、左心室舒张功能和血管硬度的改善,并且通过产生更大的肥胖减少,饮食加运动将比单独饮食或运动更有效地改善心血管参数。第三个目的是研究饮食、运动和腹部肥胖影响心血管结局的机制。这些机制包括全身炎症、胰岛素敏感性、有氧和力量健身、血糖控制、瘦素、脂联素和心血管疾病危险因素。我们将招募相同数量的男性和女性,在次要分析中,我们将探索治疗反应的性别差异。这项研究将为超重和肥胖的2型糖尿病患者的饮食和运动减少腹部脂肪和改善心血管健康的机制提供新的见解。2型糖尿病主要是由于肥胖,特别是腹部肥胖和缺乏运动,在美国正以流行率增加,并显着增加心血管疾病的风险。糖尿病患者的心血管结构和功能异常甚至在个体遭受心脏事件如心脏病发作或发展为心力衰竭之前就出现了。这项研究将检查饮食和运动,无论是单独或组合,减少腹部肥胖和改善心血管参数的程度,这些参数是超重和肥胖2型糖尿病患者心血管疾病的早期标志物。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kerry J. Stewart其他文献
Morphological and physiological factors related to endurance performance of 11- to 12-year-old girls.
与 11 至 12 岁女孩耐力表现相关的形态和生理因素。
- DOI:
- 发表时间:
1978 - 期刊:
- 影响因子:0
- 作者:
Bernard Gutin;America Trinidad;Cheryl Norton;Elizabeth Giles;Anna Giles;Kerry J. Stewart - 通讯作者:
Kerry J. Stewart
Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men.
每晚单次注射生长激素释放激素 (GHRH 1-29) 对健康老年男性的影响。
- DOI:
10.1016/s0026-0495(97)90174-8 - 发表时间:
1997 - 期刊:
- 影响因子:0
- 作者:
Janet Vittone;M. R. Blackman;Jan Busby;Chris Tsiao;Kerry J. Stewart;Jordan D. Tobin;T. Stevens;M. Bellantoni;Marc A. Rogers;Gerhard Baumann;Jesse Roth;S. Harman;Richard G.S. Spencer - 通讯作者:
Richard G.S. Spencer
Effects of physical training on cardiorespiratory fitness in children.
体能训练对儿童心肺健康的影响。
- DOI:
- 发表时间:
1976 - 期刊:
- 影响因子:0
- 作者:
Kerry J. Stewart;Bernard Gutin - 通讯作者:
Bernard Gutin
TCT-404: Percutaneous Treatment of Symptomatic Central Venous Stenosis
- DOI:
10.1016/j.jacc.2010.08.473 - 发表时间:
2010-09-21 - 期刊:
- 影响因子:
- 作者:
Mark A. Creager;Michael Belkin;Edward I. Bluth;Donald E. Casey;Seemant Chaturvedi;Michael D. Dake;Jerome L. Fleg;Alan T. Hirsch;Michael R. Jaff;John A. Kern;David J. Malenka;Edward T. Martin;Emile R. Mohler;Timothy Murphy;Jeffrey W. Olin;Judith G. Regensteiner;Robert H. Rosenwasser;Peter Sheehan;Kerry J. Stewart;Diane Treat-Jacobson - 通讯作者:
Diane Treat-Jacobson
TCT-405: A New Concept of Stent: the Multilayer Stent. First Human Study in Arterial Aneurysms
- DOI:
10.1016/j.jacc.2010.08.474 - 发表时间:
2010-09-21 - 期刊:
- 影响因子:
- 作者:
Mark A. Creager;Michael Belkin;Edward I. Bluth;Donald E. Casey;Seemant Chaturvedi;Michael D. Dake;Jerome L. Fleg;Alan T. Hirsch;Michael R. Jaff;John A. Kern;David J. Malenka;Edward T. Martin;Emile R. Mohler;Timothy Murphy;Jeffrey W. Olin;Judith G. Regensteiner;Robert H. Rosenwasser;Peter Sheehan;Kerry J. Stewart;Diane Treat-Jacobson - 通讯作者:
Diane Treat-Jacobson
Kerry J. Stewart的其他文献
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{{ truncateString('Kerry J. Stewart', 18)}}的其他基金
Two Diets With Exercise in Abdominal Obesity: Cardiovascular Effects
腹部肥胖的两种饮食加运动:对心血管的影响
- 批准号:
7728008 - 财政年份:2009
- 资助金额:
$ 79.77万 - 项目类别:
Two Diets With Exercise in Abdominal Obesity: Cardiovascular Effects
腹部肥胖的两种饮食加运动:对心血管的影响
- 批准号:
7930635 - 财政年份:2009
- 资助金额:
$ 79.77万 - 项目类别:
EXERCISE TRAINING IN TYPE 2 DIABETES AND HYPERTENSION
2 型糖尿病和高血压的运动训练
- 批准号:
7607469 - 财政年份:2006
- 资助金额:
$ 79.77万 - 项目类别:
EXERCISE TRAINING IN TYPE 2 DIABETES AND HYPERTENSION
2 型糖尿病和高血压的运动训练
- 批准号:
7375824 - 财政年份:2005
- 资助金额:
$ 79.77万 - 项目类别:
EXERCISE TRAINING IN OLDER HYPERTENSIVE MEN AND WOMEN
老年高血压男性和女性的运动训练
- 批准号:
7204419 - 财政年份:2004
- 资助金额:
$ 79.77万 - 项目类别:
Exercise training in type 2 diabetes and hypertension
2型糖尿病和高血压的运动训练
- 批准号:
6731344 - 财政年份:2004
- 资助金额:
$ 79.77万 - 项目类别:
Exercise training in type 2 diabetes and hypertension
2型糖尿病和高血压的运动训练
- 批准号:
7163522 - 财政年份:2004
- 资助金额:
$ 79.77万 - 项目类别:
Exercise training in type 2 diabetes and hypertension
2型糖尿病和高血压的运动训练
- 批准号:
6849317 - 财政年份:2004
- 资助金额:
$ 79.77万 - 项目类别:
EXERCISE TRAINING IN TYPE 2 DIABETES AND HYPERTENSION
2 型糖尿病和高血压的运动训练
- 批准号:
7204459 - 财政年份:2004
- 资助金额:
$ 79.77万 - 项目类别:
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