EXERCISE TRAINING IN TYPE 2 DIABETES AND HYPERTENSION

2 型糖尿病和高血压的运动训练

• 批准号: 7375824
• 负责人: Kerry J. Stewart
• 金额: $ 80.25万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375824
• 关键词: EXERCISE; TRAINING; TYPE; DIABETES; HYPERTENSION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Type 2 diabetes is associated with damage, dysfunction, and failure of various organs. The coexistence of diabetes and hypertension is particularly damaging to cardiac and peripheral vascular structure and function. Although exercise is often endorsed as a therapeutic modality for type 2 diabetes, most studies of exercise and diabetes have focused upon glycemic control, rather than cardiovascular health. Although exercise lowers blood pressure in hypertensive individuals without diabetes, there are significant gaps in the knowledge regarding the effects of exercise training on blood pressure and cardiovascular health in persons with type 2 diabetes. The primary specific aim of this protocol is to determine if exercise training reduces blood pressure in persons who have both type 2 diabetes and high normal blood pressure or mild hypertension. In addition, the effects of exercise training on parameters of cardiac and peripheral vascular structure related to cardiovascular disease in diabetes and hypertension will be determined.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。2型糖尿病与各种器官的损伤、功能障碍和衰竭有关。糖尿病和高血压的共存对心脏和外周血管结构和功能特别有害。虽然运动经常被认可为2型糖尿病的治疗方式，但大多数关于运动和糖尿病的研究都集中在血糖控制上，而不是心血管健康。虽然运动可以降低无糖尿病的高血压患者的血压，但关于运动训练对2型糖尿病患者血压和心血管健康的影响的知识存在显着差距。本方案的主要具体目的是确定运动训练是否能降低2型糖尿病和正常高血压或轻度高血压患者的血压。此外，将确定运动训练对与糖尿病和高血压患者心血管疾病相关的心脏和外周血管结构参数的影响。