Renovation for Safety & Long-Term Support of Rodent Research at Univ. Cincinnati

安全改造

• 批准号: 7934416
• 负责人: JANE E STRASSER
• 金额: $ 844万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-04 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7934416
• 关键词: Allergens; Animal Housing; Animals; Core Facility; Disabled Persons; Disease; Economics; Employee; Environment; Equipment; Exposure to; Facility Accesses; Facility Designs; Floor; Funding; Future; Grant; Growth; Healthcare; House mice; Housing; Human Resources; Lead; Medical; Monitor; Occupations; Procedures; Recruitment Activity; Research; Research Personnel; Rodent; Safety; Science; Scientist; Security; Steam; Sterilization; System; Transgenic Animals; Transgenic Organisms; Translational Research; Universities; Update; Water; animal care; animal facility; exposed human population; handicapping condition; improved; innovation; meetings; square foot

DESCRIPTION (provided by applicant): The Medical Sciences Building (MSB) animal facility at the University of Cincinnati was constructed 35 years ago to house primarily large-animal species. MSB is currently unable to meet the present and future needs for bench and translational research utilizing barrier-level and transgenic rodents. Without the ability to improve the MSB core facility, UC would be handicapped in recruiting top scientists and providing a supportive, innovative environment that will lead to new scientific discoveries, more jobs, and economic growth. There is an urgent need, therefore, to remodel the MSB animal facility to meet current and future rodent-research requirements. The objective of this project is to optimize and contemporize MSB animal care space; producing larger, more efficient housing and procedure rooms, increasing vivarium security, reducing human exposure to allergens and zoonotic agents, and eliminating inter-building transport of animal cages for sterilization/autoclaving, making it more energy and water efficient. The proposed renovations would support $53,538,423 ongoing, extramurally funded grants and $66,823,919 that are pending. The rationale underlying this request is that updating this facility will increase the quality of animal care, the prominence of rodent-related research, decrease allergen exposure of users/employees of the facility, and allow continued expansion of research to meet present and future needs of researchers at the University of Cincinnati. We will attain our objective by pursuing the following specific aims: 1. Increase animal space by eliminating the original, outdated facility design of clean/dirty corridor systems for large-animal species to form a barrier-housing facility with expansion of rodent housing and creation of additional procedure rooms for an increased number of barrier-housed/transgenic animals that will meet the future needs of UC researchers. Renovation will in- crease utilizable animal space from 14,985 to 25,573 sq ft and mouse housing capacity from 13,391 to 23,380 cages, an approximate 70% expansion in each case. 2. Optimize space use by facility employees by relocating administrative/locker room space outside the MSB vivarium reducing human exposure to animal allergens and zoonotic diseases. Separation of the personnel and animal spaces will reduce unnecessary facility access, increase security, and minimize exposure to zoonotic agents/animal allergens while facilitating more efficient utilization of the vivarium. 3. Increase water and energy efficiency of steam sterilization by purchasing two energy/water-efficient, floor-loading Getinge GE 92222 large autoclaves to centralize MSB autoclaving, thus improving efficiency by autoclaving larger loads, eliminating staff transport of caging and equipment to other facilities for autoclaving while reducing water and energy use with newer, more efficient autoclaves. The 70% projected expansion of rodent cages for MSB will benefit the University of Cincinnati by increasing efficiency of animal housing into larger rooms that will be easier to clean and monitor animal health care, improving efficiency of cage and equipment sterilization to meet current and future research demands.

描述（由申请人提供）：辛辛那提大学的医学科学楼（MSB）动物设施建于35年前，主要用于饲养大型动物。MSB目前无法满足目前和未来利用屏障水平和转基因啮齿动物进行实验室和转化研究的需求。如果没有能力改善MSB核心设施，UC将无法招募顶尖科学家并提供支持性的创新环境，这将导致新的科学发现，更多的就业机会和经济增长。因此，迫切需要改造MSB动物设施，以满足当前和未来的啮齿动物研究要求。该项目的目标是优化和现代化MSB动物护理空间;生产更大，更高效的住房和手术室，提高动物饲养场的安全性，减少人类暴露于过敏原和人畜共患病病原体，并消除动物笼的建筑物间运输以进行灭菌/高压灭菌，使其更加节能和节水。拟议的翻修将支持53，538，423美元正在进行的，由外部资助的赠款和66，823，919美元正在等待。这一要求的依据是，更新该设施将提高动物护理的质量，突出啮齿动物相关研究，减少设施用户/员工的过敏原暴露，并允许继续扩大研究，以满足辛辛那提大学研究人员目前和未来的需求。我们将通过以下具体目标来实现我们的目标：1.通过消除大型动物物种的清洁/肮脏走廊系统的原始过时设施设计来增加动物空间，以形成屏障圈养设施，扩大啮齿动物圈养，并为更多数量的屏障圈养/转基因动物创建额外的手术室，以满足UC研究人员的未来需求。翻新工程将使可使用的动物空间由14，985平方呎增加至25，573平方呎，而鼠笼容量则由13，391笼增加至23，380笼，每项工程均会增加约70%。2.通过将管理/更衣室空间迁移到MSB动物饲养场之外，优化设施员工的空间使用，减少人类暴露于动物过敏原和人畜共患病。人员和动物空间的分离将减少不必要的设施访问，提高安全性，并最大限度地减少暴露于人畜共患病病原体/动物过敏原，同时促进更有效地利用动物饲养场。3.通过购买两台节能/节水型、落地式Getinge GE 92222大型高压灭菌器来集中进行MSB高压灭菌，从而提高蒸汽灭菌的水和能源效率，从而通过高压灭菌更大的负载来提高效率，消除工作人员将笼和设备运送到其他设施进行高压灭菌，同时使用更新、更高效的高压灭菌器减少水和能源的使用。MSB啮齿动物笼的70%预计扩展将使辛辛那提大学受益，因为它将动物饲养效率提高到更大的房间，更容易清洁和监测动物保健，提高笼和设备灭菌效率，以满足当前和未来的研究需求。