Multisensory integration and self-motion perception in primate vestibular cortex
灵长类动物前庭皮层的多感觉整合和自我运动感知
基本信息
- 批准号:10753017
- 负责人:
- 金额:$ 7.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-16 至 2025-08-15
- 项目状态:未结题
- 来源:
- 关键词:AnimalsAreaAuditoryAutomobile DrivingAwarenessBehaviorBehavioralBody partBrainCellsClinicalCognitiveCutaneousEnvironmentEquilibriumEthologyFunctional disorderGaitGoalsHeadHead MovementsHumanImpairmentIndividualInjuryInsula of ReilLearningLesionModalityModelingMotionMotion PerceptionMotorMovementMusculoskeletal EquilibriumNeuronal DifferentiationNeuronsOrganismOutcomeParietal LobePatientsPerceptionPhysiciansPlayPopulationPosturePrimatesProcessReportingResearchRoleSchemeSelf PerceptionSensorySignal TransductionSkeletal muscle structure of neckSpace PerceptionStimulusStreamSystemTactileTestingThalamic NucleiThalamic structureVertebratesVestibular nucleus structureVisualclinically relevantcognitive functioncognitive processdensityexperienceexperimental studyextracellulargazeimaging studyimprovedinsightmultimodalitymultisensoryneuralneuromechanismneurophysiologynonhuman primateresponsesensory inputsensory integrationsomatosensoryway finding
项目摘要
Project Summary
In vertebrate animals, the vestibular system (primarily known as the “balance system” of the brain) interprets
head-movement and orientation signals to provide organisms with a sense of self-motion. The vital contribution
of vestibular system to reflexive control of posture, gaze, and gait is well characterized; however, far less is
known about the neural substrates underlying higher-order vestibular functions, such as the perception of self-
motion and the awareness of one's orientation in space. These functions rely on the cortical integration of
vestibular input with somatosensory and visual input. In non-human primates, the parieto-insular vestibular
cortex (PIVC) is uniquely suited to perform this multisensory integration. Unlike other vestibular-sensitive cortical
areas, PIVC has direct access to vestibular, somatosensory, and visual input from the thalamus; indeed, it is
hypothesized that other vestibular cortical areas receive their vestibular input from PIVC, thus making it a nexus
for higher-order vestibular function. Despite its hypothesized importance, extremely little is known about the
neural mechanisms by which PIVC integrates vestibular and extra-vestibular input, and whether this integration
is context dependent. For example, it is unclear whether PIVC neurons differentiate between vestibular input
generated during passive vs. active movements; such differentiation is seen in the vestibular nuclei and thalamus
and is thought to be essential for producing a sense of motor agency. To investigate these issues, I propose to
conduct high-density neurophysiological recordings in behaving primates during both passive stimulation and
actively generated head and whole-body movement. In Aim 1, I will investigate how PIVC integrates passively
applied vestibular and somatosensory input (Aim 1.1) and then vestibular and visual input (Aim 1.2). In Aim 2, I
will investigate whether PIVC differentially processes vestibular input during passive and active movement.
Specifically, I will examine how PIVC processes vestibular input generated during natural self-motion (i.e., self-
motion relying on sensorimotor input in the form of a head-turning task, Aim 2.1). I will then examine how PIVC
processes vestibular input generated during a learned, cognitively demanding motor task (Aim 2.2). In both aims,
I will determine how individual neurons in PIVC encode vestibular and extra-vestibular input, as well as how this
information is represented at the population level. The proposed experiments will resolve two questions which
are fundamental to understanding PIVC function: 1) How does PIVC integrate multisensory input to construct a
percept of self-motion? and 2) Is the processing of self-motion by PIVC neurons consistent with that required to
provide a sense of motor agency? Furthermore, the proposed experiments will determine how sensorimotor and
cognitive percepts of self-motion are represented in PIVC. This research will provide new insights into cortical
vestibular function and how it supports the higher-order processes that allow primates (both human and non-
human) to successfully perceive and navigate their environments.
项目总结
项目成果
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