Multisensory integration and self-motion perception in primate vestibular cortex
灵长类动物前庭皮层的多感觉整合和自我运动感知
基本信息
- 批准号:10753017
- 负责人:
- 金额:$ 7.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-08-16 至 2025-08-15
- 项目状态:未结题
- 来源:
- 关键词:AnimalsAreaAuditoryAutomobile DrivingAwarenessBehaviorBehavioralBody partBrainCellsClinicalCognitiveCutaneousEnvironmentEquilibriumEthologyFunctional disorderGaitGoalsHeadHead MovementsHumanImpairmentIndividualInjuryInsula of ReilLearningLesionModalityModelingMotionMotion PerceptionMotorMovementMusculoskeletal EquilibriumNeuronal DifferentiationNeuronsOrganismOutcomeParietal LobePatientsPerceptionPhysiciansPlayPopulationPosturePrimatesProcessReportingResearchRoleSchemeSelf PerceptionSensorySignal TransductionSkeletal muscle structure of neckSpace PerceptionStimulusStreamSystemTactileTestingThalamic NucleiThalamic structureVertebratesVestibular nucleus structureVisualclinically relevantcognitive functioncognitive processdensityexperienceexperimental studyextracellulargazeimaging studyimprovedinsightmultimodalitymultisensoryneuralneuromechanismneurophysiologynonhuman primateresponsesensory inputsensory integrationsomatosensoryway finding
项目摘要
Project Summary
In vertebrate animals, the vestibular system (primarily known as the “balance system” of the brain) interprets
head-movement and orientation signals to provide organisms with a sense of self-motion. The vital contribution
of vestibular system to reflexive control of posture, gaze, and gait is well characterized; however, far less is
known about the neural substrates underlying higher-order vestibular functions, such as the perception of self-
motion and the awareness of one's orientation in space. These functions rely on the cortical integration of
vestibular input with somatosensory and visual input. In non-human primates, the parieto-insular vestibular
cortex (PIVC) is uniquely suited to perform this multisensory integration. Unlike other vestibular-sensitive cortical
areas, PIVC has direct access to vestibular, somatosensory, and visual input from the thalamus; indeed, it is
hypothesized that other vestibular cortical areas receive their vestibular input from PIVC, thus making it a nexus
for higher-order vestibular function. Despite its hypothesized importance, extremely little is known about the
neural mechanisms by which PIVC integrates vestibular and extra-vestibular input, and whether this integration
is context dependent. For example, it is unclear whether PIVC neurons differentiate between vestibular input
generated during passive vs. active movements; such differentiation is seen in the vestibular nuclei and thalamus
and is thought to be essential for producing a sense of motor agency. To investigate these issues, I propose to
conduct high-density neurophysiological recordings in behaving primates during both passive stimulation and
actively generated head and whole-body movement. In Aim 1, I will investigate how PIVC integrates passively
applied vestibular and somatosensory input (Aim 1.1) and then vestibular and visual input (Aim 1.2). In Aim 2, I
will investigate whether PIVC differentially processes vestibular input during passive and active movement.
Specifically, I will examine how PIVC processes vestibular input generated during natural self-motion (i.e., self-
motion relying on sensorimotor input in the form of a head-turning task, Aim 2.1). I will then examine how PIVC
processes vestibular input generated during a learned, cognitively demanding motor task (Aim 2.2). In both aims,
I will determine how individual neurons in PIVC encode vestibular and extra-vestibular input, as well as how this
information is represented at the population level. The proposed experiments will resolve two questions which
are fundamental to understanding PIVC function: 1) How does PIVC integrate multisensory input to construct a
percept of self-motion? and 2) Is the processing of self-motion by PIVC neurons consistent with that required to
provide a sense of motor agency? Furthermore, the proposed experiments will determine how sensorimotor and
cognitive percepts of self-motion are represented in PIVC. This research will provide new insights into cortical
vestibular function and how it supports the higher-order processes that allow primates (both human and non-
human) to successfully perceive and navigate their environments.
项目摘要
在脊椎动物中,前庭系统(主要称为大脑的“平衡系统”)解释
头部运动和方位信号,为生物体提供自我运动感。最重要的贡献
前庭系统对姿势、凝视和步态的反射控制有很好的特点;然而,远没有。
已知高阶前庭功能的神经基础,如自我感知
动作和对自己在空间中的方位的意识。这些功能依赖于大脑皮质的整合
具有体感和视觉输入的前庭输入。在非人灵长类动物中,顶岛前庭
皮层(PIVC)特别适合进行这种多感官整合。与其他对前庭敏感的皮质不同
PIVC可以直接从丘脑获得前庭、躯体感觉和视觉输入;事实上,它是
假设其他前庭皮质区域接受来自PIVC的前庭输入,从而使其成为一个神经节
更高级的前庭功能。尽管它被假设为重要的,但人们对它知之甚少
PIVC整合前庭和前庭外输入的神经机制,以及这种整合
与上下文相关。例如,目前尚不清楚PIVC神经元是否区分前庭输入
在被动和主动运动过程中产生的;这种分化见于前庭核团和丘脑
并被认为是产生一种运动代理感的关键。为了调查这些问题,我建议
对行为灵长类动物进行高密度神经生理记录,包括被动刺激和
积极地产生头部和全身的运动。在目标1中,我将调查PIVC如何被动地整合
应用前庭和躯体感觉输入(目标1.1),然后是前庭和视觉输入(目标1.2)。在目标2中,我
将研究PIVC在被动和主动运动过程中是否对前庭输入进行不同处理。
具体地说,我将研究PIVC如何处理在自然自我运动(即,自我运动)过程中产生的前庭输入
运动依赖于以转头任务形式的感觉运动输入,目标2.1)。然后我将研究PIVC是如何
处理在习得的、认知要求高的运动任务中产生的前庭输入(目标2.2)。在这两个目标中,
我将确定PIVC中的单个神经元如何编码前庭和前庭外的输入,以及这是如何
信息是在人口层面上表示的。拟议的实验将解决以下两个问题
是理解PIVC功能的基础:1)PIVC如何整合多感觉输入来构建
对自我运动的感知?2)PIVC神经元对自我运动的处理是否与所需的一致
提供一种马达代理的感觉?此外,拟议的实验将确定感觉运动和
自我运动的认知知觉在PIVC中表现出来。这项研究将提供对大脑皮层的新见解
前庭功能以及它如何支持灵长类动物(包括人类和非人类)的高级突起
人类)来成功地感知和导航它们的环境。
项目成果
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