Pediatric Template of Brain Perfusion
儿科脑灌注模板
基本信息
- 批准号:7815448
- 负责人:
- 金额:$ 2.15万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-30 至 2010-05-04
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescenceAdultAgeAnisotropyArtsAtlasesBackBase of the BrainBehaviorBehavioralBiological Neural NetworksBlood flowBook ChaptersBrainBrain DiseasesBrain regionCerebrovascular CirculationCerebrumChildChildhoodClinicalCognitiveCommunitiesComputer softwareContrast MediaCross-Sectional StudiesDataData CollectionData SetDatabasesDependenceDevelopmentDiffusionDiffusion Magnetic Resonance ImagingEvaluationEvolutionFunctional Magnetic Resonance ImagingFundingFutureHippocampus (Brain)HumanImageImage AnalysisJournalsKnowledgeLightLongitudinal StudiesMagnetic Resonance ImagingMeasurementMeasuresMemoryMental disordersMethodologyMethodsModalityMultivariate AnalysisNational Institute of Mental HealthNeuroanatomyNeurodevelopmental DisorderParentsParietalPatternPediatric HospitalsPediatric ResearchPeer ReviewPennsylvaniaPerformancePerfusionPerfusion Weighted MRIPhiladelphiaPhysiologicalPopulationPositioning AttributePrefrontal CortexProcessProductivityPropertyProtocols documentationPublic HealthPublicationsRadioisotopesRegional PerfusionRelative (related person)ReproducibilityResearchResourcesRestSafetyScanningSex CharacteristicsShort-Term MemorySignal TransductionSpin LabelsStatistical sensitivityStructureSystemTechnical ExpertiseThickTimeUniversitiesUpdateVariantWorkagedangular gyrusassociation cortexbasebioimagingblood flow measurementblood oxygen level dependentcognitive neurosciencecohortdesignimage registrationimaging modalityimprovedindexingmorphometryneurogeneticsneuroimagingparent projectpre-clinicalpublic health relevancerelating to nervous systemresponsewhite matter
项目摘要
DESCRIPTION (provided by applicant): We propose "An Integrated Pediatric Template of Brain Structure and Function" - a multivariate quantitative image assessment of the developing brain. The template will be openly available to all and will be used to enumerate the interaction between working memory performance and cortical and connectivity maturation. The parent project's over-arching aim is validate, construct and distribute a MRI-based statistical atlas (or template) that describes the developmental trajectory of blood flow patterns (or perfusion) in the "normal" pediatric brain and its responses to working memory tasks. Here, we add depth to the imaging dataset collected from this large cohort through additional, state-of-the-art scanning. We also add rigor and breadth of appeal to the associated analysis by introducing cutting-edge computational neuroanatomy and multivariate statistical processing to tease out cross-modality interactions, network-node relationships and effects of these on cognitive processing. In particular, we achieve this through advanced diffusion tensor imaging, cutting-edge cortical thickness and analyses and multivariate sparse regression of the parameters, along with perfusion, and working memory performance.
PUBLIC HEALTH RELEVANCE: This proposal responds to public health needs through large-scale data collection that enables studies of cross-sectional sex differences in developmental trajectories and behavior. Secondly, the proposal supports longitudinal neuroimaging studies in mental disorders by performing a normative 4 time point multi-modality study of normal longitudinal development in 30 children.
描述(由申请人提供):我们提出了“一个集成的儿科模板的大脑结构和功能”-一个多变量的定量图像评估的发展中的大脑。 该模板将向所有人开放,并将用于列举工作记忆表现与皮层和连接成熟之间的相互作用。 母项目的首要目标是验证,构建和分发基于MRI的统计图谱(或模板),描述“正常”儿科大脑中血流模式(或灌注)的发展轨迹及其对工作记忆任务的反应。 在这里,我们通过额外的最先进的扫描,为从这个大型队列收集的成像数据集增加了深度。 我们还通过引入尖端的计算神经解剖学和多元统计处理来梳理跨模态相互作用,网络节点关系以及这些对认知处理的影响,从而增加了相关分析的严谨性和吸引力。 特别是,我们通过先进的扩散张量成像、尖端的皮质厚度和分析以及参数的多元稀疏回归、沿着的灌注和工作记忆性能来实现这一目标。
公共卫生相关性:该提案通过大规模的数据收集来满足公共卫生需求,从而能够研究发展轨迹和行为的横截面性别差异。 其次,该建议支持纵向神经影像学研究精神障碍进行规范的4个时间点的多模态研究正常纵向发展的30名儿童。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Danny JJ WANG其他文献
Danny JJ WANG的其他文献
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{{ truncateString('Danny JJ WANG', 18)}}的其他基金
Massively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain
成人大脑的大规模并行高速 3D 功能光声计算机断层扫描
- 批准号:
10685975 - 财政年份:2020
- 资助金额:
$ 2.15万 - 项目类别:
Massively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain
成人大脑的大规模并行高速 3D 功能光声计算机断层扫描
- 批准号:
10007184 - 财政年份:2020
- 资助金额:
$ 2.15万 - 项目类别:
Massively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain
成人大脑的大规模并行高速 3D 功能光声计算机断层扫描
- 批准号:
10470400 - 财政年份:2020
- 资助金额:
$ 2.15万 - 项目类别:
Massively parallel high-speed 3D functional photoacoustic computed tomography of the adult human brain
成人大脑的大规模并行高速 3D 功能光声计算机断层扫描
- 批准号:
10256763 - 财政年份:2020
- 资助金额:
$ 2.15万 - 项目类别:
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