Pediatric Template of Brain Perfusion

描述(由申请者提供)：我们提出了“脑结构和功能的综合儿科模板”--对发育中的脑进行多变量定量图像评估。该模板将向所有人开放，并将用于列举工作记忆表现与皮质和连接性成熟之间的相互作用。母项目的总体目标是验证、构建和分发基于MRI的统计图谱(或模板)，该图谱(或模板)描述了“正常”儿科大脑中血流模式(或灌流)的发展轨迹及其对工作记忆任务的反应。在这里，我们通过额外的、最先进的扫描为从这个大队列收集的成像数据集增加深度。我们还通过引入尖端计算神经解剖学和多变量统计处理来梳理跨通道交互、网络-节点关系以及这些对认知处理的影响，从而增加了关联分析的严密性和广度。特别是，我们通过先进的扩散张量成像、尖端皮质厚度和分析以及参数、血流灌注和工作记忆性能的多变量稀疏回归实现了这一点。 公共卫生相关性：这项建议通过大规模数据收集来回应公共卫生需求，从而能够研究发展轨迹和行为中的横断面性别差异。其次，该提案通过对30名儿童的正常纵向发育进行标准化的4个时间点的多模式研究，支持精神障碍的纵向神经成像研究。

DESCRIPTION (provided by applicant): We propose "An Integrated Pediatric Template of Brain Structure and Function" - a multivariate quantitative image assessment of the developing brain. The template will be openly available to all and will be used to enumerate the interaction between working memory performance and cortical and connectivity maturation. The parent project's over-arching aim is validate, construct and distribute a MRI-based statistical atlas (or template) that describes the developmental trajectory of blood flow patterns (or perfusion) in the "normal" pediatric brain and its responses to working memory tasks. Here, we add depth to the imaging dataset collected from this large cohort through additional, state-of-the-art scanning. We also add rigor and breadth of appeal to the associated analysis by introducing cutting-edge computational neuroanatomy and multivariate statistical processing to tease out cross-modality interactions, network-node relationships and effects of these on cognitive processing. In particular, we achieve this through advanced diffusion tensor imaging, cutting-edge cortical thickness and analyses and multivariate sparse regression of the parameters, along with perfusion, and working memory performance. PUBLIC HEALTH RELEVANCE: This proposal responds to public health needs through large-scale data collection that enables studies of cross-sectional sex differences in developmental trajectories and behavior. Secondly, the proposal supports longitudinal neuroimaging studies in mental disorders by performing a normative 4 time point multi-modality study of normal longitudinal development in 30 children.