Age-Related Macular Degeneration: A Genetic Epidemiology Study in the Amish

年龄相关性黄斑变性：阿米什人的遗传流行病学研究

• 批准号: 7963499
• 负责人: DARBY THOMPSON
• 金额: $ 20万
• 依托单位: THE EMMES COMPANY, LLC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-11-01 至 2011-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7963499
• 关键词: Age; Related; Macular; Degeneration; Genetic

Recruitment for this study is on-going. Refractive error is a common ocular condition in the US and without correction, the vision in an affected eye is impaired. The most prevalent refractive error, myopia or nearsightedness, is increasing in frequency in many parts of the world. Although a genetic predisposition is believed to predispose individuals to develop myopia, other environmental factors such as near work activities are also thought to influence susceptibility. The Old Order Amish have an unique, largely agrarian lifestyle, avoid modern technology, and discontinue all formal schooling after the eighth grade. Because their environmental exposures are internally homogenous and do not entail much near work activity, we decided to investigate the distribution of refractive error, specifically myopia and hyperopia (farsightedness) within Amish sibships who are participants in this cohort study. We found that rates of myopia and hyperopia in the Old Order Amish siblings are lower than those observed in other population groups of similar age structure. Myopia and hyperopia were also observed to aggregate within sibships. Genetic factors are estimated to account for 70% of the variability in refractive error in these Amish sibships.

本研究的招募工作正在进行中。屈光不正在美国是一种常见的眼部疾病，如果不进行矫正，受影响的眼睛的视力就会受损。最普遍的屈光不正，近视或近视，在世界许多地方的发病率正在增加。虽然遗传易感性被认为使个体易患近视，但其他环境因素，如近距离工作活动，也被认为会影响易感性。旧秩序的阿米什人有一种独特的、以农业为主的生活方式，避开现代科技，八年级后就停止了所有正规的学校教育。由于他们的环境暴露在内部是同质的，并且不需要太多的近距离工作活动，我们决定调查屈光不正的分布，特别是近视和远视（远视）在参加这项队列研究的阿米什兄弟姐妹中。我们发现Old Order Amish兄弟姐妹的近视和远视率低于其他类似年龄结构的人群。近视和远视也被观察到在兄弟姐妹中聚集。据估计，遗传因素占阿米什兄弟姐妹屈光不正变异性的70%。