Treatment of Uveitic Cystoid Macular Edema with Topical Interferon Gamma

局部干扰素γ治疗葡萄膜囊样黄斑水肿

• 批准号: 7976142
• 负责人: DARBY THOMPSON
• 金额: $ 5.56万
• 依托单位: THE EMMES COMPANY, LLC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-11-01 至 2011-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7976142
• 关键词: Treatment; Uveitic; Cystoid; Macular; Edema

The Treatment of Uveitic Cystoid Macular Edema with Topical Interferon Gamma Uveitis is a serious inflammatory condition that affects the eye and can cause vision loss. A common secondary problem associated with uveitis is macular edema (swelling). The macula is the part of the eye that is important for central vision, and swelling of the macula can lead to further vision loss. This condition is usually treated by medicines that target the immune system, but these medicines sometimes do not work or may cause side effects. - Interferon gamma-1b (Actimmune(Registered Trademark)) is a bioengineered protein that can alter the way inflammatory cells work in the immune system. Interferon gamma-1b is given as an intramuscular injection; however, this study will use the drug as an eye drop. This study represents the first time that interferon gamma-1b is given as an eye drop. Researchers hope that interferon gamma-1b will treat macular edema by decreasing the swelling in the back

局部干扰素γ治疗葡萄膜囊样黄斑水肿 葡萄膜炎是一种严重的炎症性疾病，会影响眼睛并导致视力丧失。与葡萄膜炎相关的常见继发问题是黄斑水肿（肿胀）。黄斑是眼睛对中心视力很重要的部分，黄斑肿胀会导致视力进一步丧失。这种情况通常通过针对免疫系统的药物来治疗，但这些药物有时不起作用或可能会引起副作用。 - 干扰素 gamma-1b（Actimmune（注册商标））是一种生物工程蛋白质，可以改变炎症细胞在免疫系统中的工作方式。干扰素 γ-1b 通过肌肉注射给药；然而，这项研究将使用该药物作为滴眼剂。这项研究首次将干扰素 γ-1b 作为滴眼剂给药。研究人员希望干扰素 γ-1b 能够通过减轻背部肿胀来治疗黄斑水肿