Vitreous Proteome and Inflammatory Mediators in Ocular Inflammatory Disease
眼部炎症中的玻璃体蛋白质组和炎症介质
基本信息
- 批准号:7975936
- 负责人:
- 金额:$ 13.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-11-01 至 2011-10-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This study will examine the proteins of people with uveitis, or inflammation of the eyes. Evaluating the vitreous, the colorless transparent substance that fills the eyeball in back of the lens, is now possible with the use of new microtechnology. There is an opportunity to evaluate the kinds of proteins that are present in severe, noninfectious sight-threatening uveitis.
Patients ages 18 and older who have been enrolled in the Multicenter Uveitis Steroid Treatment (MUST) study at NIH may be eligible for this study. Up to 200 patients eventually may be enrolled. Researchers will study the vitreous that will be removed from patients' eyes during an operation to insert a steroid implant. The steroid implant is used instead of immunosuppressive therapy, a way to reduce the action of the immune system.
Patients will undergo a procedure involving a small hole made in the eye into which the implant is placed. Normally a small amount of the vitreous comes out during that procedure, and in this study, the vitreous specimen will be taken for testing of inflammatory products. At the same time, a small sample of blood, about 1-1/2 tablespoons, will be collected so that the researchers can compare inflammatory products that may be in the blood with those in the vitreous. If a patient needs to have the implant placed again during the study, he or she would be asked permission for collection of the vitreous and blood samples, as previously. Samples collected will not be used to diagnose patients' conditions or to change any treatments being done. All samples will be labeled with special code numbers so that there is no identifying information about patients. This study will not involve examinations or scheduled visits of patients.
这项研究将检查葡萄膜炎或眼睛炎症患者的蛋白质。玻璃体是一种无色透明的物质,填充在眼球的透镜后面,现在可以通过使用新的显微技术来评估。这是一个机会,以评估目前在严重的,非感染性视力威胁葡萄膜炎的蛋白质种类。
已参加NIH多中心葡萄膜炎类固醇治疗(MUST)研究的18岁及以上患者可能有资格参加本研究。最终可能招募多达200名患者。研究人员将研究在植入类固醇植入物的手术中从患者眼睛中取出的玻璃体。类固醇植入物被用来代替免疫抑制治疗,一种减少免疫系统作用的方法。
患者将接受一个手术,包括在眼睛上开一个小孔,植入植入物。通常在该过程中会有少量玻璃体流出,在本研究中,将采集玻璃体标本用于检测炎症产物。同时,将收集一小部分血液样本,大约1-1/2汤匙,以便研究人员可以比较血液中可能存在的炎症产物与玻璃体中的炎症产物。如果患者在研究期间需要再次植入植入物,则将像以前一样,要求患者允许采集玻璃体和血液样本。收集的样本不会用于诊断患者的病情或改变任何正在进行的治疗。所有样本将标有特殊代码编号,因此不存在患者的识别信息。本研究不涉及患者检查或计划访视。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DARBY THOMPSON其他文献
DARBY THOMPSON的其他文献
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{{ truncateString('DARBY THOMPSON', 18)}}的其他基金
Epigenetics, Molecular Genetics, and Biomarkers of Inflammatory Ocular Diseases
炎症性眼病的表观遗传学、分子遗传学和生物标志物
- 批准号:
7975994 - 财政年份:2006
- 资助金额:
$ 13.93万 - 项目类别:
Pilot: Finasteride Treatment for Chronic Central Serous Chorioretinopathy
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7976122 - 财政年份:2006
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Age-Related Macular Degeneration: A Genetic Epidemiology Study in the Amish
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7963499 - 财政年份:2006
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7976001 - 财政年份:2006
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Multicenter Uveitis Steroid Treatment (MUST) Trial Protocol
多中心葡萄膜炎类固醇治疗 (MUST) 试验方案
- 批准号:
7963809 - 财政年份:2006
- 资助金额:
$ 13.93万 - 项目类别:
Age-Related Eye Disease Study (AREDS) Follow-Up
年龄相关眼病研究 (AREDS) 随访
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7975982 - 财政年份:2006
- 资助金额:
$ 13.93万 - 项目类别:
Pilot: Sunitinib Malate for Advance Ocular Disease of Von Hippel-Lindau Syndrome
试点:苹果酸舒尼替尼治疗冯希佩尔-林道综合征晚期眼部疾病
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7976049 - 财政年份:2006
- 资助金额:
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Clinical and Molecular Studies in Families with Myopia and Related Diseases
近视及相关疾病家庭的临床和分子研究
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7976216 - 财政年份:2006
- 资助金额:
$ 13.93万 - 项目类别:
Intravitreal Inj of Ranibizumab for Macular Telangiectasia w/o Neovascularization
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8075874 - 财政年份:2006
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8075893 - 财政年份:2006
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