Outcomes of uveitic cataract and uveitic glaucoma surgery

项目总结 葡萄膜炎与视力受损和以下不良结局的发生率较高有关 眼内手术--如白内障手术或青光眼手术。建议的指导方针 预防视力损害和取得成功的手术结果包括静息 术前至少3个月炎症反应和严格的炎症控制 围术期，然而，关于以下方面的实践依据有限的证据 葡萄膜炎白内障手术和葡萄膜炎青光眼患者的真实结局 做手术。眼科疾病的全身免疫抑制疗法(SITE)队列研究是一项 丰富的葡萄膜炎患者数据库(17,907名不同的患者跟踪了169,194次访问)， 炎症状态、接受的药物、手术和其他方面的详细信息 结果。该数据库包括超过250名18岁以下患有葡萄膜炎的儿童 白内障手术和100多名接受葡萄膜炎青光眼手术的儿童 关于儿童葡萄膜炎白内障和儿童葡萄膜炎青光眼的文献非常稀少。病人 曾接受切开白内障或青光眼手术，并在此之前的6个月内最少曾就诊一次 手术和至少两次术后超过8周的随访包括在 分析。这项资助的结果可以(1)指导临床医生和患者：最佳 患者围手术期的管理，以达到最佳的视力和 眼压控制，(2)探索后续眼内手术的发生率， 尤其是在儿童中，这将影响手术的计划和(3)指导围术期 预防眼内炎症和继发眼内炎症的手术治疗 最佳视觉效果。是否让孩子无晶状体征，以及是否让孩子有晶状体障碍 小梁切除术或导管分流术与长期眼压控制有关，因此 保留视功能，通过这种分析将会有循证的指导。 这些目标响应国家眼科研究所的战略计划和目标，以 支持有关失明眼病和保护视力的应用临床研究， 特别是确定葡萄膜炎的病因和病因，并改进其治疗方法 诊断、治疗和预防。“

Project summary Uveitis is associated with visual impairment and higher incidence of poor outcomes following intraocular surgery—such as cataract surgery or glaucoma surgery. Guidelines proposed to prevent visual impairment and achieve successful surgical outcomes include quiescence of inflammation for atleast 3 months pre-operatively and stringent inflammation control in the perioperative period, however there is limited evidence on which to based practice regarding the real-world outcomes for patients who undergo uveitic cataract surgery and uveitic glaucoma surgery. The Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study is a rich database of uveitis patients (17,907 distinct patients followed over 169,194 visits) with very detailed information on inflammatory status, medications received, surgeries and other outcomes. The database includes over 250 children under the age of 18 who have had uveitic cataract surgery and over 100 children who underwent uveitic glaucoma surgeries, in a field with very sparse literature on pediatric uveitic cataracts and pediatric uveitic glaucoma. Patients who had incisional cataract or glaucoma surgery with at least one visit in the 6 months prior to surgery and at least two post-operative visits beyond 8 weeks postoperatively are included in the analysis. The results from this grant could (1) guide clinicians and patients re: the optimal management of patients in the peri-operative period to achieve best possible visual acuity and intraocular pressure control, (2) explore the incidence of subsequent intraocular surgeries, especially among children, which would impact the planning of surgeries and (3) guide the peri- operative management of patients to prevent intraocular inflammation and subsequently the best visual outcomes. The question of whether to leave a child aphakic or not and whether a trabeculectomy or tube shunt is associated with longer term intraocular pressure control, thus preserving visual function, will have evidence-based guidelines through this analysis. These objectives are responsive to the Strategic Plan and goals of the National Eye Institute, to support applied clinical research concerning blinding eye diseases and preservation of sight, especially the goal “Establish the causes and etiology of uveitis and improve methods for its diagnosis, treatment, and prevention.”